Neutrophil-to Lymphocyte and Monocyte-to-Lymphocyte Ratio... | NCT07003204

Studies
Neutrophil-to Lymphocyte and Monocyte-to-Lymphocyte Ratios in Exudative Pleural Effusion

NCT07003204

Sponsor

Alexandria University

Status

Completed

Last Update Posted

Jun 4, 2025Actual

Enrollment

60Actual

Phase

Not provided

Conditions

Effusion

Interventions

medical thoracoscopy

Countries

Egypt

Protocol Section

Identification Module Status Module Sponsor/Collaborators Module Oversight Module Description Module Conditions Module Design Module Arms/Interventions Module Outcomes Module Eligibility Module Contacts/Locations Module References Module IPD Sharing Statement Module

Results Section

Participant Flow Module Baseline Characteristics Module Outcome Measures Module Adverse Events Module More Info Module

Annotation Section

Annotation Module

Document Section

Large Document Module

Derived Section

Miscellaneous Info Module Condition Browse Module Intervention Browse Module

Protocol Section

Identification Module

NCT ID

Results Section

No data available

No data is available for this block.

Annotation Section

No data available

No data is available for this block.

Document Section

No data available

No data is available for this block.

Derived Section

Miscellaneous Info Module

Version Holder

Status Module

Record Verification Date

May 2025

Overall Recruitment Status or Expanded Access Status

Completed

Last Known Status

Not provided

Delayed Posting

Not provided

Why Stopped

Not provided

Expanded Access Info

Start Date

May 11, 2025Actual

Primary Completion Date

May 25, 2025Actual

Completion Date

May 26, 2025Actual

First Submitted Date

May 26, 2025

First Submission Date that Met QC Criteria

May 26, 2025

First Posted Date

Jun 4, 2025Actual

Results Waived

Not provided

Results First Submitted Date

Not provided

Results First Submitted that Met QC Criteria

Not provided

Results First Posted Date

Not provided

Certification/Extension (aka Delayed Results) First Submitted Date

Not provided

Certification/Extension First Submitted that Passed QC Review

Not provided

Certification/Extension First Posted Date

Not provided

Last Update Submitted Date

May 26, 2025

Last Update Posted Date

Jun 4, 2025Actual

Oversight Module

Has Data Monitoring Committee (DMC)

Yes

Is FDA Regulated Drug

Is FDA Regulated Device

Is Unapproved Device

Not provided

Pediatric Postmarket Surveillance of a Device Product

Not provided

Product Exported from US

Not provided

FDAAA801 Violation

Not provided

Description Module

Brief Summary

Exudative pleural effusion (EPE) presents a diagnostic challenge, requiring accurate biomarkers to predict outcomes and guide treatment. The neutrophil-to-lymphocyte ratio (NLR) and monocyte-to-lymphocyte ratio (MLR) in pleural fluid are emerging as potential prognostic markers. We aimed to assess the diagnostic and prognostic utility of pleural fluid NLR and MLR in EPE.

Detailed Description

Pleural fluid NLR and MLR are reliable biomarkers for diagnosing malignant pleural effusion and predicting poorer survival outcomes. These ratios may be useful in clinical practice, especially in resource-limited settings, to guide decision-making in the management of pleural effusions.

Design Module

Study Type

Observational

Number of References to an Expanded Access Study

Not provided

Expanded Access Types

Not provided

Patient Registry

Target Follow-Up Duration

Not provided

Phases

Not provided

Interventional Study Design

Allocation

Not provided

Intervention Model

Biospecimen

No data available

No data is available for this block.

Enrollment

60Actual

Arms/Interventions Module

Arm Groups

Label	Type	Description	Intervention Names
only one group of patients		prospective cohort randomized control study	Procedure: medical thoracoscopy

Interventions

Name	Type	Description	Arm Group Labels	Other Names
medical thoracoscopy	Procedure	pleural fluid aspiration and cellular analysis	only one group of patients

Outcomes Module

Primary Outcomes

Measure	Description	Time Frame
MLR and NLR measuring in pleural fluid	counting pleural fluid monocytes,lymphocytes and neutrophils	1 month

Secondary Outcomes

Not provided

Other Outcomes

Measure	Description	Time Frame
MLR and NLR measuring in pleural fluid	counting the pleural monocytes, neutrophils and lymphoctes	one month

Eligibility Module

Eligibility Criteria

Inclusion Criteria:

adult patients aged 18-80 years with an EPE diagnosis confirmed by thoracentesis.

Exclusion Criteria:

Exclusion criteria included patients with a history of recent surgery, corticosteroid use, or those with mixed effusion types.

Accepts Healthy Volunteers

Sex

All

Sex/Gender Based

Not provided

Sex/Gender Description

Not provided

Minimum Age

18 Months

Maximum Age

Not provided

Standard Ages

ChildAdultOlder Adult

Study Population

60 person with pleural effusion

Sampling Method

Non-Probability Sample

Contacts/Locations Module

Central Contacts

Not provided

Overall Officials

Name	Affiliation	Role
mohamed Sabry eltarhony, lecturer	Alexandria University	Principal Investigator

Locations

Facility	Status	City	State	ZIP	Country	Contacts
Chest Department -Faculty of Medicine		Alexandria	Egypt	11511	Egypt

Label	URL
https://pmc.ncbi.nlm.nih.gov/articles/PMC8075197/	View source

ID	Type	URL	Comment
msabry776@yahoo.com	Clinical Study Report	View IPD

IPD Sharing Statement Module

Plan to Share IPD

Description

not in the policy of the department

Types

Not provided

Time Frame

Not provided

Access Criteria

Not provided

URL

Not provided