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| ID | Type | Description | Link |
|---|---|---|---|
| 90SFE0071 | Other Grant/Funding Number | National Institute on Disability, Independent Living, and Rehabilitation Research |
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| Name | Class |
|---|---|
| National Institute on Disability, Independent Living, and Rehabilitation Research | FED |
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We are examining the use of restricted blood flow, through full occlusion, on a single thigh for 50 minutes (5 minutes on, 5 minutes off), completed every other day for 2 weeks to improve function in individuals with knee osteoarthritis and low back pain.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| IC Arm | Experimental |
| |
| Sham Arm | Sham Comparator |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Ischemic Preconditioning | Device | The intervention arm will include full blood flow occlusion in one thigh for 5 minutes followed by 5 minutes of reperfusion for a cycle of 50 minutes. |
| Measure | Description | Time Frame |
|---|---|---|
| Preferred walking speed | Changes in preferred walking speed (m/s) from intervention | At baseline (from enrollment) until end of intervention (3 weeks). |
| Muscle strength | Change in quadriceps, hamstring, and hip strength | From baseline (enrollment) until end of intervention (3 weeks) |
| Patient Reported Outcomes | Change in subjective function and reporting based on questionnaires | At baseline (enrollment) through the intervention (3 weeks) |
| Gait Kinematics | Changes in gait kinematics (in degrees) from intervention | At baseline (from enrollment) until end of intervention (3 weeks). |
| Gait Kinetics/Moments | Changes in gait kinetics (joint moments) (in N/m) from intervention | At baseline (from enrollment) until end of intervention (3 weeks). |
| Measure | Description | Time Frame |
|---|---|---|
| Cartilage Health | Change in knee cartilage thickness using ultrasound methods | From baseline (enrollment) until completion of intervention (3 weeks) |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Shraddha Sudhir | Contact | 312-413-5118 | ssudhi5@uic.edu |
| Name | Affiliation | Role |
|---|---|---|
| Lindsay Hannigan | University of Illinois at Chicago | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Human and Sport Performance Lab | Recruiting | Chicago | Illinois | 60608 | United States |
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| ID | Term |
|---|---|
| D017116 | Low Back Pain |
| D020370 | Osteoarthritis, Knee |
| D001416 | Back Pain |
| ID | Term |
|---|---|
| D010146 | Pain |
| D009461 | Neurologic Manifestations |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
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| ID | Term |
|---|---|
| D019194 | Ischemic Preconditioning |
| ID | Term |
|---|---|
| D013812 | Therapeutics |
| D008919 | Investigative Techniques |
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| Sham Intervention | Device | This intervention includes 25mmHg of pressure, which is not sufficient for blodo flow occlusion. |
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| D010003 | Osteoarthritis |
| D001168 | Arthritis |
| D007592 | Joint Diseases |
| D009140 | Musculoskeletal Diseases |
| D012216 | Rheumatic Diseases |