The aim of this study is to assess the effectiveness of Platelet-Rich Fibrin (PRF) in improving postoperative healing, reducing complications, and enhancing functional outcomes in patients undergoing septoplasty

Septoplasty is a routine surgical intervention to correct nasal septal deviation, a major cause of nasal obstruction and chronic sinusitis. Despite advancements, postoperative complications-such as mucosal injury, synechiae, septal perforation, and hematoma-continue to impact outcomes and patient satisfaction.

Platelet-rich fibrin (PRF), first described by Choukroun et al., represents an autologous biomaterial rich in growth factors like PDGF, TGF-β, VEGF, and IGF-1, known to accelerate wound healing and tissue regeneration. Unlike platelet-rich plasma (PRP), PRF is easier to prepare, does not require anticoagulants, and forms a fibrin matrix conducive to sustained release of cytokines.

Several studies across disciplines-oral surgery, dermatology, orthopedics-support the regenerative potential of PRF. In nasal surgery, the delicate mucosal environment could benefit significantly from enhanced healing facilitated by PRF.

Inclusion Criteria:

• Adults aged 18-65 years undergoing septoplasty. Presence of cartilage deviated nasal septum requiring repair. No contraindications to PRF therapy.

Exclusion Criteria:

• History of coagulopathy or anticoagulant therapy. Active infection or systemic disease. Known hypersensitivity to PRF components. Previous nasal surgery Autoimmune or systemic inflammatory disease