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| ID | Type | Description | Link |
|---|---|---|---|
| 4R00AG078561-03 | U.S. NIH Grant/Contract | View source |
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| Name | Class |
|---|---|
| National Institute on Aging (NIA) | NIH |
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Developing efficient cognitive intervention for cognitively health older adults is a major public health goal, due to its potential for reducing age-related cognitive decline and Alzheimer's disease/dementia risk. Executive Control is a relevant cognitive target since it declines with aging and is critical for multi-tasking in daily life. The proposed research investigates whether playing a web-based cognitive complex game (the Breakfast Game) impacts cognitive performance in cognitively healthy older adults. To be enrolled in the study, participants will be asked to undergo a cognitive sassessment, health questionnires, and a blood exam. The intervention consist in one educational session on healthy aging, and 10 one-hour cognitive training sessions 2-3 times a week over one month. Participants will be asked to repeat the cognitive assessment within 1-2 weeks after the intervention, and after three months.
The proposed research investigates whether exposure to a web-based training protocol designed to enhance executive control / multi-tasking abilities will improve cognitive performance in cognitively healthy older adults. Cognitively normal adults aged 60-75 will be randomized into three groups: 1) Web-based game with training strategy (Experimental); 2) Web-based game without training strategy (Active Control); 3) No intervention group (Passive control). Participants in groups 1 and 2 will be instructed to play the complex, high-demand online game, the Breakfast Game, for 10 one-hour sessions over 4 weeks. At study entry all participants will be asked to complete a cognitive assessment, health questionnaires, a blood exam and and education session on healthy aging. After the intervention, participants will be asked to repeat the cogntive assessment within 1-2 weeks, and after 3 months.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Strategy Training | Experimental | Participants will undergo a web-based training protocol that involves playing an online game simulating a breakfast environment, where they will perform everyday activities such as "cooking" and "setting tables" in a multitasking fashion. Participants will learn to play the game using specific strategies to optimize their performance. |
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| Regular Training | Active Comparator | Participants will undergo a web-based training protocol that involves playing an online game simulating a breakfast environment, where they will perform everyday activities such as "cooking" and "setting tables" in a multitasking fashion. Participants will learn to play the game under regular game instructions. |
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| Passive Control | No Intervention |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Web-based Cognitive Training (with strategy) | Behavioral | Participants will learn to play a complex online game using specific guidance or strategy. |
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| Measure | Description | Time Frame |
|---|---|---|
| Changes in the Breakfast Game scores | Change in the total game performance based on specific scores (number of tables and cooking scores). Higher scores represent better game outcomes. | Training session 1, week 1; training 10, approximately 4 weeks. |
| Transfer to complex executive/attention control measure (Proximal outcome). | Alphanumeric Task score. | At baseline (week 1); post-intervention (weeks 10th to 12th); and at 3-month follow-up (week 24th) |
| Measure | Description | Time Frame |
|---|---|---|
| Transfer to executive functions composite measure (Proximal outcome) | Average z-score computed with tests involving working memory, divided attention, and inhibitory control (Letter-Number, UFOV and Stroop) | At baseline (week 1); post-intervention (weeks 10th to 12th); and at 3-month follow-up (week 24th) |
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Inclusion Criteria:
Age 60-75
Adequate English proficiency
Willingness to adhere to training protocol:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Thamiris Golçalves Clinical Research Coordinator, MS | Contact | 973-972-2977 | engaging.lab@rutgers.edu | |
| Ana Staniscia Associate Research, MS | Contact | ana.staniscia@rutgers.edu |
| Name | Affiliation | Role |
|---|---|---|
| Sharon Sanz Simon Assistant Professor, Ph.D. | Rutgers University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Rutgers New Jersey Medical School, Behavior Health Sciences Building, F-Level | Recruiting | Newark | New Jersey | 07103 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 21120135 | Background | Blumen HM, Gopher D, Steinerman JR, Stern Y. Training cognitive control in older adults with the space fortress game: the role of training instructions and basic motor ability. Front Aging Neurosci. 2010 Nov 11;2:145. doi: 10.3389/fnagi.2010.00145. eCollection 2010. | |
| 21988726 | Background | Stern Y, Blumen HM, Rich LW, Richards A, Herzberg G, Gopher D. Space Fortress game training and executive control in older adults: a pilot intervention. Neuropsychol Dev Cogn B Aging Neuropsychol Cogn. 2011 Nov;18(6):653-77. doi: 10.1080/13825585.2011.613450. Epub 2011 Oct 12. |
| Label | URL |
|---|---|
| EngAGING Lab Website | View source |
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Data obtained through this study may be provided to qualified researchers with academic interest in lifestyle intervention in aging.. Data or samples shared will be coded, with no private health information (PHI) included. Approval of the request and execution of all applicable agreements (i.e. a material transfer agreement) are prerequisites to the sharing of data with the requesting party.
Data requests can be submitted starting 6 months after article publication, and the data will be made accessible for up to 24 months. Extensions will be considered on a case-by-case basis.
Access to trial IPD can be requested by qualified researchers engaging in independent scientific research and will be provided following review and approval of a research proposal and Statistical Analysis Plan (SAP) and execution of a Data Sharing Agreement (DSA). For more information or to submit a request, please contact the PI lab email: engaging.lab@rutgers.edu.
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Participants will not be aware of the difference between the two active conditions. Assessor will not be aware in which group condition the participant was allocated.
| Web-based Cognitive Training (without strategy) | Behavioral | Participants will learn to play a complex online game without specific guidance or strategy. |
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| Transfer to Everyday Cognition Scale (ECOG) (Distal outcome) |
Scores on a scale that measures cognitive difficulties in everyday life. A higher score indicates higher levels of cognitive difficulties or change. |
| At baseline (week 1); post-intervention (weeks 10th to 12th); and at 3-month follow-up (week 24th) |
| Transfer to Mindful Attention Awareness Scale (MAAS) (Distal outcome) | Scores on a scale that measures attention awareness. A higher score indicates higher levels of attention awareness. | At baseline (week 1); post-intervention (weeks 10th to 12th); and at 3-month follow-up (week 24th) |
| Transfer to Self Efficacy for Cognitive Everyday Tasks (Distal outcome) | Scores on a scale that measures self-efficacy. A higher score indicates higher levels of self-efficacy. | At baseline (week 1); post-intervention (weeks 10th to 12th); and at 3-month follow-up (week 24th) |
| 37542331 | Background | Sanz Simon S, Ben-Eliezer D, Pondikos M, Stern Y, Gopher D. Feasibility and acceptability of a new web-based cognitive training platform for cognitively healthy older adults: the breakfast task. Pilot Feasibility Stud. 2023 Aug 4;9(1):136. doi: 10.1186/s40814-023-01359-2. |