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This is a prospective, single-site, non-randomized, interventional study. The purpose is to collect electrocardiographic (ECG) and echocardiographic (echo) parameters and computed tomography (CT) images (optional) during Bachmann's bundle area pacing (BBAP) and conventional pacing in the right atrial appendage (RAA) to compare the differences between atrial pacing modalities and to further investigate the clinical outcomes of BBAP.
Bachmann's bundle (BB) has emerged as an alternative pacing location to conventional right atrial appendage (RAA) pacing and is expected to avoid the interatrial conduction delay (IACD) and atrial dyssynchrony induced by RAA pacing. A recent study reported in patients with atrial pacing indications and baseline IACD that decreased atrial arrhythmia burden, recurrence, and de novo incidence were found in BB pacing, compared with right atrial septal pacing and RAA pacing. This study aimed to collect electrocardiographic (ECG) and echocardiographic (echo) parameters and CT images during BB area pacing (BBAP) and conventional pacing in the right atrial appendage (RAA) during regular pacemaker implantation procedures. The purpose is to compare the differences between atrial pacing modalities and to further investigate the clinical outcomes of BBAP.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Single Arm - BBAP and RAA pacing | Experimental | Bachmann's bundle area pacing (BBAP) and conventional pacing in the right atrial appendage during regular pacemaker implantation procedures are applied for acute electrocardiogram and echocardiogram testings. BBAP will be kept with remaining implantation procedure and followed-up at 3 months and/or 6 months. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| BBAP and RAA pacing | Procedure | Bachmann's bundle area pacing and conventional pacing in the right atrial appendage during regular pacemaker implantation procedures are applied for acute electrocardiogram and echocardiogram testings. |
| Measure | Description | Time Frame |
|---|---|---|
| Atrial-paced ECG P-wave duration at implantation and during regular follow-ups | From implantation to regular follow-ups up to 6 months | |
| Atrial-paced ECG P-wave amplitude at implantation and during regular follow-ups | From implantation to regular follow-ups up to 6 months | |
| Atrial-paced P-onset to A-wave initiation time under Doppler at mitral and tricuspid valves at implantation | Perioperative |
| Measure | Description | Time Frame |
|---|---|---|
| LAD from echocardiographic measurements before implantation and during regular follow-ups | Baseline before implantation to regular follow-ups up to 6 months |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Shanghai Tong Ren Hospital | Shanghai | Shanghai Municipality | 200000 | China |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 41446938 | Derived | Qiu Z, Wu X, Hu W, Tang Y, Xu Z, Ou Z, Zhou Y, Ren Z, Shi T, Lu H. Interatrial Synchronized Pacing at the Posterosuperior Bundle: Feasibility, Mechanism, and Mid-Term Outcomes. Circ Arrhythm Electrophysiol. 2026 Jan;19(1):e014357. doi: 10.1161/CIRCEP.125.014357. Epub 2025 Dec 25. |
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| ID | Term |
|---|---|
| D001919 | Bradycardia |
| ID | Term |
|---|---|
| D001145 | Arrhythmias, Cardiac |
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
| D010335 | Pathologic Processes |
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| D013568 |
| Pathological Conditions, Signs and Symptoms |