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The goal of this clinical trial is to evaluate the immunogenicity and safety of booster immunization of varicella live attenuated vaccine (varicella vaccine hereafter) at different intervals.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Group A | Experimental | Participants received a single dose of varicella vaccine as booster immunization 3 months after their primary vaccination. |
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| Group B | Experimental | Participants received a single dose of varicella vaccine as booster immunization 18-30 months after their primary vaccination. |
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| Group C | Experimental | Participants received a single dose of varicella vaccine as booster immunization 36-48 months after their primary vaccination. |
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| Group D | Experimental | Participants received a single dose of varicella vaccine as booster immunization 60-72 months after their primary vaccination. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Varicella vaccine | Biological | lyophilized powder, subcutaneous injection |
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| Measure | Description | Time Frame |
|---|---|---|
| Geometric mean titer (GMT) of varicella-zoster virus (VZV) antibodies | GMT of VZV antibodies 30 days after booster dose immunization | 30 days after booster dose immunization |
| Measure | Description | Time Frame |
|---|---|---|
| Seroconversion rate of varicella-zoster virus (VZV) antibodies | Seroconversion rate of VZV antibodies 30 days after booster dose immunization | 30 days after booster dose immunization |
| Seropositive rate of varicella-zoster virus (VZV) antibodies |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Jiangsu Provincial Center for Disease control and Prevention | Nanjing | Jiangsu | 210009 | China |
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| ID | Term |
|---|---|
| D019433 | Chickenpox Vaccine |
| ID | Term |
|---|---|
| D022283 | Herpesvirus Vaccines |
| D014765 | Viral Vaccines |
| D014612 | Vaccines |
| D001688 | Biological Products |
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Seropositive rate of VZV antibodies 30 days after booster dose immunization
| 30 days after booster dose immunization |
| Geometric mean increase (GMI) of varicella-zoster virus (VZV) antibodies | GMI of VZV antibodies 30 days after booster dose immunization | 30 days after booster dose immunization |
| D045424 |
| Complex Mixtures |