Effect of Topical Bromelain Versus Topical Corticosteroids in the Management of Recurrent Aphthous Stomatitis

Evaluation of Topical Bromelain Versus Topical Corticosteroids in Management of Recurrent Aphthous Stomatitis: A Randomized Controlled Trial

Bromelain, a natural product, exhibits anti-inflammatory, immunomodulatory, and wound-healing properties. However, its efficacy in treating oral mucosal ulcers remains unexplored. This study aims to evaluate the effect of bromelain as a safe alternate for management of RAS.

Inclusion Criteria:

• Adults aged 18-60 years.
• Diagnosed with RAS.
• Onset of ulcer within the last 48 hours.
• Willingness to participate and provide informed consent.

Exclusion Criteria:

• History of hematological deficiencies, GIT disorders, Behcet's disease and major systemic diseases.
• Pregnant or breastfeeding patients.
• Previous treatment for the current ulcer episode.