This is a Phase 1, open label, first-in-human study to evaluate safety, tolerability, Pharmacokinetics (PK), Pharmacodynamics (PD), immunogenicity and anti-tumor activity of SHR-4712 in patients with advanced solid tumors. Patients will treat with SHR-4712 until unacceptable toxicity or disease progression.

Inclusion Criteria:

1. The subject voluntarily participates in this study and signs the informed consent form.
2. The subject is aged between 18 and 75 years old (inclusive), regardless of gender.
3. The subject must provide tumor tissue samples for biomarker testing.
4. The subject's ECOG performance status is 0 or 1.
5. The expected survival time is ≥ 12 weeks.
6. The subject has at least one measurable lesion that meets the requirements of RECIST v1.1.
7. Laboratory test results confirm that the subject has sufficient functions of vital organs.
8. Female subjects of child-bearing potential must not be breastfeeding, have no possibility of pregnancy, and agree to comply with relevant contraceptive requirements.

Exclusion Criteria:

1. The subject has a history of or currently has meningeal metastases, or has symptomatic and active central nervous system metastases.
2. The subject has spinal cord compression that has not been radically treated by surgery and/or radiotherapy.
3. The subject has uncontrollable tumor-related pain as judged by the investigator.
4. The subject has clinically symptomatic moderate or severe ascites, uncontrollable pleural effusion or pericardial effusion of moderate amount or more.
5. The subject has received systemic immunosuppressive treatment within 14 days before the first study drug administration.
6. The subject has active autoimmune diseases or a history of autoimmune diseases with a possibility of recurrence.
7. The subject has severe cardiovascular and cerebrovascular diseases.
8. The subject has other uncontrolled concomitant diseases before the first drug administration.
9. The subject has a history of severe allergic reactions to the test drug and its main formulation components.
10. The subject has a history of immunodeficiency, including positive HIV serological test results, and other acquired or congenital immunodeficiency diseases.
11. The subject has had a severe infection within 4 weeks before the first drug administration.
12. The subject has a history of active pulmonary tuberculosis infection within 1 year before enrollment as found through medical history or CT examination, or has a history of active pulmonary tuberculosis infection more than 1 year ago but has not received regular treatment.
13. The subject has other serious physical or mental diseases, known alcohol or drug dependence, abnormal laboratory test results, and other factors that may increase the risk of participating in the study or interfere with the study results, and any other situations that the investigator deems unsuitable for participation in this study.