Impact of Ultraviolet Radiation and Environmental Factors on Human Ocular Biomechanics

Association Between Ultraviolet Radiation, Environmental Factors, and Ocular Biomechanical Properties: A Multicenter Cross-Sectional Study

This observational study aims to explore whether ultraviolet (UV) radiation and other environmental factors are associated with ocular biomechanical properties in healthy volunteers aged 18-44 years without ocular diseases, ocular surgery history, or systemic diseases.

The main questions it aims to answer are:

Is there a significant correlation between UV radiation levels and corneal biomechanical parameters?

Do environmental factors such as geographic region and seasonal variation affect corneal biomechanical behavior?

Researchers will compare ocular biomechanical parameters among populations from different geographic regions with varying levels of UV radiation to determine whether there are statistically significant correlations or differences.

Participants will:

Undergo standardized ophthalmic examinations, including visual acuity, intraocular pressure, slit-lamp evaluation, axial length, and corneal topography;

Receive corneal biomechanical assessments using the Corvis ST device;

Provide basic demographic information and medical history;

Have all data de-identified, with the study strictly following ethical approval and privacy protection protocols.

Inclusion Criteria:

• Inclusion Criteria

Age between 18 and 44 years (based on WHO criteria);

Spherical equivalent refraction (SER) ≤ 6.00 diopters;

No other ocular diseases;

No systemic diseases (e.g., diabetes, hypertension, cardiovascular diseases);

No severe psychiatric or psychological disorders;

No history of ocular surgery.

Exclusion Criteria

Severe psychiatric disorders;

Individuals diagnosed with keratoconus, suspected keratoconus, or subclinical keratoconus (based on the Global Consensus on Keratoconus Diagnosis);

Presence of other ocular diseases (e.g., glaucoma, corneal opacity, uveitis);

History of intraocular or ocular surface surgeries;

Presence of nystagmus or inability to cooperate with examinations;

History of intraocular surgery;

Presence of systemic diseases (e.g., diabetes, hypertension, cardiovascular diseases).

Exclusion Criteria:

• Severe psychiatric disorders;

Individuals diagnosed with keratoconus, suspected keratoconus, or subclinical keratoconus (based on the Global Consensus on Keratoconus Diagnosis);

Presence of other ocular diseases (e.g., glaucoma, corneal opacity, uveitis);

History of intraocular or ocular surface surgeries;

Presence of nystagmus or inability to cooperate with examinations;

History of intraocular surgery;

Presence of systemic diseases (e.g., diabetes, hypertension, cardiovascular diseases).