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DW-MRI Allows a quantitative comparison of diffusion as an expression of tissue hypoxia. The investigators aim is to compare changes in placental diffusion in pregnant women with uncontrolled diabetes compared to healthy pregnant women using DW-MRI.
The investigators hypothesize that placentas of diabetic mothers will show lower diffusion / perfusion compared to placentas of healthy women.
In highly uncontrolled diabetes there is an increased risk of intrauterine fetal death. The mechanism of fetal death is unknown and unpredictable. One of the theories points to hypoxia as a precursor to the death of the fetus in the womb. If the researchers succeed in predicting changes in the placenta with the help of MRI, it may be possible to understand the mechanism of fetal damage as well as in the future to develop a protocol for predicting pregnancies prone to fetal death in the womb.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Pregnant women with gestational diabetes mellitus | Experimental | 3Th trimester pregnant women with gestational diabetes mellitus |
|
| Low risk pregnant women | Active Comparator | 3Th trimester pregnant women with unknown diseases (low risk factors) |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| DW-MRI | Diagnostic Test | Predict changes in ovarian diffusion using DW-MRI scan |
|
| Measure | Description | Time Frame |
|---|---|---|
| Placental diffusion coefficient (D) measured by IVIM-DWI | Placental diffusion coefficient (D, mm²/s) derived from intravoxel incoherent motion diffusion-weighted MRI (IVIM-DWI). Mean D values will be extracted from whole-placenta regions of interest and compared between parturients with poorly controlled diabetes and excessive fetal growth and low-risk parturients with appropriately grown fetuses. | Two years |
| Measure | Description | Time Frame |
|---|---|---|
| Placental perfusion fraction (f) measured by IVIM-DWI | Placental perfusion fraction (f, unitless) derived from intravoxel incoherent motion diffusion-weighted MRI (IVIM-DWI). Mean f values will be extracted from whole-placenta regions of interest and compared between parturients with poorly controlled diabetes and excessive fetal growth and low-risk parturients with appropriately grown fetuses | Two years |
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Inclusion Criteria:
Exclusion Criteria:
Pregnant women
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Rinat Gabbay-Benziv, Prof | Contact | +972-4-7744514 | rinatg@hymc.gov.il | |
| Moran Rotman, MD | Contact | +972-4-7744514 | MORANR@hymc.gov.il |
| Name | Affiliation | Role |
|---|---|---|
| Rinat Gabbay-Benziv, Prof | Hillel Yaffe Medical Center | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Hille Yaffe Medical Center | Recruiting | Hadera | 38100 | Israel |
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| ID | Term |
|---|---|
| D011254 | Pregnancy in Diabetics |
| D010922 | Placenta Diseases |
| ID | Term |
|---|---|
| D011248 | Pregnancy Complications |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
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| ID | Term |
|---|---|
| D038524 | Diffusion Magnetic Resonance Imaging |
| ID | Term |
|---|---|
| D008279 | Magnetic Resonance Imaging |
| D014054 | Tomography |
| D003952 | Diagnostic Imaging |
| D019937 | Diagnostic Techniques and Procedures |
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The 2 arms will include 3th trimester pregnant women. Group 1- diabetic pregnant women Group 2- low risk pregnant women
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| D003933 | Diagnosis |