In this study, we compared two types of phacoemulsification commonly used in cataract surgery to evaluate their effect on the prognosis of patients with hard nuclei. This will provide a theoretical basis for selecting a more appropriate cataract surgery modality in practice in hard-nucleus patients.

In this study, we randomized patients into two groups. One group was the combined mode group in burst mode and the other group was the torsional ultrasound group in continuous mode. Cumulative dissipated energy(CDE) and ultrasound time(UST) were recorded during the procedure. Changes in central cornea thickness(CCT) and endothelial cell density(ECD) of the patients were recorded postoperatively during a 3-month follow-up. Intraoperative and postoperative complications were also recorded. The above data were analyzed to compare the effect of both on postoperative corneal recovery in patients with hard nuclei.

Inclusion Criteria:

• patients with age-related cataracts that were only classified by Emery-Little as nuclear hardness grade III-V.
• encompassed a minimum dilated pupil diameter of 7 mm or above, as well as a corneal endothelial cell count exceeding 1200/mm^2.
• Corneal morphology is normal and clear
• Informed consent is required prior to enrollment

Exclusion Criteria:

• Those with white cataracts, histories of eye surgery, and eye diseases such as corneal pathology, uveitis, Fuchs' dystrophy, and glaucoma were excluded.
• Exclude those with comorbid ocular and systemic diseases that affect corneal endothelial cell function
• Exclude those with previous intraocular surgery

Study Protocol, Statistical Analysis Plan, and Informed Consent Form will be shared.

2024.1.26, for 1month

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