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This prospective, observational cohort study aims to establish a long-term registry of adult patients with atrial fibrillation (AF) in China to comprehensively characterize patient profiles and evaluate real-world management and outcomes over time. The objectives of the study are to:
Participants will undergo standardized baseline evaluation and longitudinal follow-up to collect data on heart rhythm monitoring, treatment exposures, healthcare utilization, clinical events, and patient-reported outcomes. This cohort will generate real-world evidence to inform personalized and evidence-based management of AF.
This prospective, multicenter observational registry aims to collect standardized clinical data on adults with atrial fibrillation (AF) across over 30 hospitals in China. The study reflects real-world clinical practice and does not interfere with treatment decisions.
Baseline and follow-up data will be collected using standardized forms, including demographics, medical history, cardiovascular risk factors, laboratory and imaging results, medication use, and-when applicable-procedural details for catheter ablation, such as energy source and complications.
Follow-up will be conducted at 1, 2, 3, and 6 months after enrollment, and every 6 months thereafter. Data include ECG monitoring, medication updates, hospitalizations, adverse events (e.g., stroke, bleeding, cardiovascular death), and healthcare utilization. Quality of life, cognitive, and psychological assessments may also be collected.
All treatments are determined by physicians as part of usual care. The registry provides internal feedback on potential treatment issues and generates periodic, anonymized summaries for participating centers.
The study aims to inform clinical practice and support real-world evidence generation to improve AF management in China.
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| Measure | Description | Time Frame |
|---|---|---|
| All-cause death | Death due to any cause. | 10 years |
| Measure | Description | Time Frame |
|---|---|---|
| Ischemic Stroke | An acute episode of neurological dysfunction caused by focal cerebral, spinal, or retinal infarction, confirmed by neuroimaging (CT or MRI) or clinical criteria consistent with permanent tissue injury. | 5 years |
| Hemorrhagic Stroke |
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Inclusion Criteria:
Exclusion Criteria:
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Adults (≥18 years) with documented atrial fibrillation enrolled from multiple hospitals across China.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Liu He, PhD | Contact | +86 13810720787 | theliu@139.com |
| Name | Affiliation | Role |
|---|---|---|
| Changsheng Ma, MD | Beijing Anzhen Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Beijing Anzhen Hospital | Recruiting | Beijing | Beijing Municipality | 100029 | China |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 42158122 | Derived | Ren L, Peng X, Li M, He L, Zhou N, Liu X, Zuo S, Dong J, Ma C, Guo X. Association of left ventricular geometry with outcomes and treatment response in atrial fibrillation and heart failure with preserved ejection fraction. Front Med (Lausanne). 2026 May 4;13:1824509. doi: 10.3389/fmed.2026.1824509. eCollection 2026. |
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| ID | Term |
|---|---|
| D001281 | Atrial Fibrillation |
| ID | Term |
|---|---|
| D001145 | Arrhythmias, Cardiac |
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
| D010335 | Pathologic Processes |
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Bleeding within the brain parenchyma or into the subarachnoid space due to rupture of cerebral blood vessels. Subtypes include intracerebral hemorrhage and subarachnoid hemorrhage.
| 5 years |
| Transient ischemic attack (TIA) | A sudden onset of neurological deficit lasting less than 24 hours. | 5 years |
| Cardiovascular Death | Death resulting from cardiovascular causes, including acute myocardial infarction, sudden cardiac death, heart failure, stroke, fatal bleeding, or complications related to cardiovascular interventions. | 5 years |
| Cardiovascular Hospitalization | Unplanned hospital admission primarily due to cardiovascular causes, including acute coronary syndrome, heart failure exacerbation, arrhythmia, stroke, cardiovascular procedures, or thromboembolic or bleeding complications. | 5 years |
| Systemic Embolism | An acute arterial occlusion outside the central nervous system, confirmed by imaging or surgery, with clinical evidence of embolic origin. Events limited to pulmonary embolism are excluded. | 5 years |
| Thromboembolic Death | Death that occurs in the context of a confirmed or suspected thromboembolic event, such as ischemic stroke or systemic embolism, without an alternative non-cardiovascular cause. | 5 years |
| Major Bleeding | Defined according to the International Society on Thrombosis and Haemostasis (ISTH) as any of the following: (1)Fatal bleeding; (2) Symptomatic bleeding in a critical area or organ (e.g., intracranial, intraspinal, intraocular, pericardial, retroperitoneal); (3) A fall in hemoglobin of ≥2 g/dL (20 g/L), or leading to transfusion of ≥2 units of whole blood or red cells. | 5 years |
| Clinically Relevant Non-Major Bleeding (CRNMB) | Any bleeding that does not meet the criteria for major bleeding but is associated with medical intervention, unscheduled physician contact, temporary interruption of treatment, or discomfort sufficient to interfere with daily activities. | 5 years |
| Sir Run Run Shaw Hospital, Zhejiang University School of Medicine | Recruiting | Hangzhou | Zhejiang | 310009 | China |
|
| D013568 |
| Pathological Conditions, Signs and Symptoms |