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| ID | Type | Description | Link |
|---|---|---|---|
| 1R01HL175642-01 | U.S. NIH Grant/Contract | View source |
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| Name | Class |
|---|---|
| National Heart, Lung, and Blood Institute (NHLBI) | NIH |
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The ADHINCRA Program is a bundle of multilevel evidence-based interventions that address multiple predictors of controlled hypertension, including patient-, provider-, and health system-level factors. The successful implementation of the ADHINCRA program will provide a rigorous and scalable model for improving hypertension control in Africa, which would ultimately reduce the risk of cardiovascular disease, stroke and kidney disease.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Cohort 1 | Experimental | This cohort will be the first to participate in the ADHINCRA Program, which includes home blood pressure monitoring, an mHealth app, nurse-led lifestyle counselling and treatment with a simplified hypertension control protocol. |
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| Cohort 2 | Experimental | This cohort will begin the ADHINCRA Program 3 months after Cohort 1. |
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| Cohort 3 | Experimental | This cohort will begin the ADHINCRA Program 6 months after Cohort 1. |
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| Cohort 4 | Experimental | This cohort will begin the ADHINCRA Program 9 months after Cohort 1. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| ADHINCRA Program | Behavioral | The ADHINCRA Program is a nurse-led intervention that includes the use of home blood pressure monitoring, a mobile health app, lifestyle counselling, and a simplified hypertension treatment protocol to achieve blood pressure control among people diagnosed with hypertension. |
| Measure | Description | Time Frame |
|---|---|---|
| Number of participants with systolic blood pressure <140 mmHg | Blood pressure control among participants defined as systolic blood pressure <140 mmHg | Baseline and 12 months post-randomization |
| Measure | Description | Time Frame |
|---|---|---|
| Number of participants with diastolic blood pressure <90 mmHg | Blood pressure control as assessed by diastolic blood pressure <90mmHg | Baseline, 12 months, 24 months post-randomization |
| Medication adherence as assessed by Hill-Bone Medication Adherence Scale |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Yvonne Commodore-Mensah, PhD, MHS, RN | Contact | 410-614-1519 | ycommod1@jhmi.edu | |
| Research Program Manager | Contact | adhincra@jh.edu |
| Name | Affiliation | Role |
|---|---|---|
| Yvonne Commodore-Mensah, PhD, MHS, RN | Johns Hopkins University | Principal Investigator |
| Fred S Sarfo, MBBS, PhD, FWACP | Kwame Nkrumah University of Science and Technology | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Johns Hopkins University | Active, not recruiting | Baltimore | Maryland | 21205 | United States | |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 36592818 | Background | Commodore-Mensah Y, Sarfo FS, Turkson-Ocran RA, Foti K, Mobula LM, Himmelfarb CD, Carson KA, Appiah LT, Degani M, Lang'at C, Nyamekye G, Molello NE, Ahima R, Cooper LA. Addressing Hypertension Care in Africa (ADHINCRA): Study protocol for a cluster-randomized controlled pilot trial. Contemp Clin Trials. 2023 Feb;125:107077. doi: 10.1016/j.cct.2022.107077. Epub 2022 Dec 30. |
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| ID | Term |
|---|---|
| D006973 | Hypertension |
| ID | Term |
|---|---|
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
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Stepped wedge cluster randomized trial
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Adherence to medications prescribed per the ADHINCRA Program treatment protocol. The total score ranges from 14 - 56. Higher score is better adherence. |
| Baseline, 12 months, 24 months post-randomization |
| Percentage of sites that adopt and maintain the intervention as assessed by the Pragmatic Robust Implementation and Sustainability Model | Use the Pragmatic Robust Implementation and Sustainability Model (PRISM) to evaluate the reach, adoption, maintenance of the ADHINCRA Program | Baseline, 12 months, 24 months post-randomization |
| Difference in cost of intervention compared to usual care as assessed by the Pragmatic Robust Implementation and Sustainability Model | Use the Pragmatic Robust Implementation and Sustainability Model (PRISM) to evaluate the cost-effectiveness of the ADHINCRA Program | Baseline, 12 months, 24 months post-randomization |
| Dike B Ojji, MBBS, PhD, FWACP | University of Abuja | Principal Investigator |
| Dominase SDA Hospital |
| Not yet recruiting |
| Bekwai |
| Ashanti Region |
| Ghana |
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| Kumasi South Hospital | Not yet recruiting | Kumasi | Ashanti Region | Ghana |
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| Manhyia Government Hospital | Recruiting | Kumasi | Ashanti Region | Ghana |
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| Tafo Government Hospital | Not yet recruiting | Tafo | Ashanti Region | Ghana |
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| Berekum Holy Family Hospital | Not yet recruiting | Berekum | Bono | Ghana |
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| St. John of God Catholic Hospital | Recruiting | Duayaw Nkwanta | Bono | Ghana |
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| Northern Regional Hospital | Recruiting | Tamale | Northern Region | Ghana |
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| Tamale Teaching Hospital | Not yet recruiting | Tamale | Northern Region | Ghana |
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| Ho Municipal Hospital | Not yet recruiting | Ho | Volta Region | Ghana |
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| South Tongu District Hospital | Not yet recruiting | Sogakope | Volta Region | Ghana |
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| Akure South Hospital | Recruiting | Akure | Ondo State | Nigeria |
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| Akoko North East | Not yet recruiting | Ondo | Ondo State | Nigeria |
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| Akoko North West | Not yet recruiting | Ondo | Ondo State | Nigeria |
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| Akoko South East | Not yet recruiting | Ondo | Ondo State | Nigeria |
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| Akoko South West | Not yet recruiting | Ondo | Ondo State | Nigeria |
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| Owo General Hospital | Not yet recruiting | Owo | Ondo State | Nigeria |
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