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The aim of this study is to observe specimens of bronchoalveolar lavage fluid from patients using a reflection enhanced dark-field scattering microscopy. By observing parameters such as the size, morphology, scattering intensity, and movement speed of pathogens, combined with the clinical characteristics of patients, a rapid diagnosis of Pseudomonas aeruginosa infection can be made. At the same time, the bronchoalveolar lavage fluid samples of patients infected with Pseudomonas aeruginosa before and after treatment were compared, and the quantity and vitality of Pseudomonas aeruginosa were observed to judge the efficacy of antibiotics.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| bronchoscopy | Procedure | We will perform bronchoscopy and collect bronchoalveolar lavage fluid (BALF) |
| Measure | Description | Time Frame |
|---|---|---|
| The size of pathogens | Measure the size of pathogens | From enrollment to the end of treatment at 2 weeks |
| scattering intensity of pathogen | Determine the shape of pathogens through scattering intensity | From enrollment to the end of treatment at 2 weeks |
| movement speed of pathogens | Measure the movement speed of pathogens, such as flagellates like Pseudomonas aeruginosa, which have a fast movement speed | From enrollment to the end of treatment at 2 weeks |
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Inclusion Criteria:
Exclusion Criteria:
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Suspected or diagnosed patients with pulmonary infection caused by Pseudomonas aeruginosa
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Wenkui Sun, Dr | Contact | +86 13914742215 | sunwenkui@njmu.edu.cn |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| The First Affiliated Hospital of Nanjing Medical University | Nanjing | Jiangsu | 21000 | China |
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The investigators will dynamically and continuously collect bronchoalveolar lavage fluid samples from participants and diagnosed with Pseudomonas aeruginosa infection.
| ID | Term |
|---|---|
| D011552 | Pseudomonas Infections |
| ID | Term |
|---|---|
| D016905 | Gram-Negative Bacterial Infections |
| D001424 | Bacterial Infections |
| D001423 | Bacterial Infections and Mycoses |
| D007239 | Infections |
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| ID | Term |
|---|---|
| D001999 | Bronchoscopy |
| ID | Term |
|---|---|
| D003948 | Diagnostic Techniques, Respiratory System |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
| D004724 | Endoscopy |
| D003949 | Diagnostic Techniques, Surgical |
| D019060 | Minimally Invasive Surgical Procedures |
| D013514 | Surgical Procedures, Operative |
| D013510 | Pulmonary Surgical Procedures |
| D019616 | Thoracic Surgical Procedures |
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