To clarify the mechanism of stress on the incidence of hyperuricemia

To clarify the differences in intestinal microorganisms and metabolism between healthy people and hyperuricemia patients and across different level of stress

Inclusion Criteria:

1. Obtain the informed consent of the subjects before conducting any trial-related activities;
2. Males aged 18-69;
3. The hyperurcemia group must meet the diagnostic criteria of having blood uric acid >420umol/L measured twice on an empty stomach on different days under a normal purine diet;

Exclusion Criteria:

- 1)Use of any uric acid-lowering drugs, anti-gout drugs, steroids, proton pump inhibitors, or non-steroidal anti-inflammatory drugs within one month before enrollment; 2)Use of any antibiotics, probiotics, or other drugs including traditional Chinese medicine within one month before enrollment; 3)Abnormal liver function, ALT and AST are more than 2.5 times the upper limit of normal; 4)Other diseases that affect glucose and lipid metabolism: hyperthyroidism, hypothyroidism, hypercortisolism, etc.

5)Chronic kidney disease or severe renal impairment, according to eGFR grading <45mL/min/1.73m2; 6)Secondary hyperuricemia 7)Any gastrointestinal diseases

Hyperuricemia patients and healthy controls