A Phase 2b Randomized, Double-blind, Placebo-controlled, Parallel-Group Study to Assess Efficacy and Safety of Verekitug (UPB-101) in Participants With Moderate-to-Severe Chronic Obstructive Pulmonary Disease (COPD)
A Phase 2b Randomized, Double-blind, Placebo-controlled, Parallel-Group Study to Assess Efficacy and Safety of Verekitug (UPB-101) in Participants With Moderate-to-Severe Chronic Obstructive Pulmonary Disease (COPD)
The purpose of this study is to assess the efficacy and safety of verekitug (UPB-101) in participants with moderate-to-severe Chronic Obstructive Pulmonary Disease (COPD), an inflammatory lung disease.
This is a global, multicenter study to assess the efficacy, safety, and tolerability of verekitug in participants with moderate-to-severe COPD. Adult participants are planned to be enrolled and will be allocated randomly in a 1:1:1 ratio to one of two dose levels of verekitug or placebo, in addition to their COPD background medications. The study consists of a screening period of approximately 4 weeks; treatment periods of between 60 weeks and up to 108 weeks; and a follow-up period, with the end-of-study visit 16 weeks after last dose.
Inclusion Criteria:
Exclusion Criteria:
Spartanburg, South Carolina 29303, United States
Buenos Aires, Buenos Aires C1414AIF, Argentina
Buenos Aires, Buenos Aires C1426ABP, Argentina
Rosario, Santa Fe Province 2000, Argentina
Dupnitsa, Pernik 2307, Bulgaria
Plovdiv, Plovdiv 4000, Bulgaria
Plovdiv, Plovdiv 4004, Bulgaria
Rousse, Ruse 7002, Bulgaria
Sofia, Sofia 1111, Bulgaria
Sofia, Sofia 1407, Bulgaria
Sofia, Sofia-Grad 1202, Bulgaria
Viña del Mar, Valparaiso 2520000, Chile
Tbilisi, K'alak'i T'bilisi 144, Georgia
Tbilisi, K'alak'i T'bilisi 159, Georgia
München, Bavaria 82131, Germany
Peine, Lower Saxony 31224, Germany
Püspökladány, Heves County 4150, Hungary
Hyderabad, Andhra Pradesh 500036, India
Rohtak, Haryana 124001, India
Kolhāpur, Maharashtra 416002, India
New Delhi, National Capital Territory of Delhi 110 001, India
Belgaum, West Bengal 590010, India
Kaunas, Kaunas County LT 50161, Lithuania
Bydgoszcz, Greater Poland Voivodeship 85-796, Poland
Poznan, Greater Poland Voivodeship 61-578, Poland
Lublin, Lubusz Voivodeship 20-078, Poland
Nowa Sól, Lubusz Voivodeship 67-100, Poland
Katowice, Warmian-Masurian Voivodeship 40-081, Poland
Szczecin, West Pomeranian Voivodeship 71-434, Poland
Brasov, Brașov County 500283, Romania
Bucuresti, Ilfov 30303, Romania
Kamenitz, Vojvodina 21204, Serbia
Banská Bystrica, Banská Bystrica Region 97517, Slovakia
Humenné, Presov 066 01, Slovakia
Wŏnju, Gang'Weondo [Kang-won-do] 26426, South Korea
Seongnam-si, Gyeonggido [Kyonggi-do] 13620, South Korea
Incheon, Incheon Gwang'Yeogsi [Inch'n-Kwangyokshi] 21431, South Korea
Seoul, Seoul Teugbyeolsi [Seoul-T'Ukpyolshi] 3722, South Korea
Kaohsiung City, Kaohsiung 833401, Taiwan
Taipei, Taipei 110, Taiwan
Taoyuan, Taoyuan 333423, Taiwan
Kyiv, Kyiv Oblast 2000, Ukraine
Kyiv, Kyiv Oblast 3038, Ukraine
Kyiv, Kyiv Oblast 3049, Ukraine
Kyiv, Luhansk Oblast 3038, Ukraine
Glasgow, Glasgow City G12 0YN, United Kingdom
Leeds, Leeds LS9 7TF, United Kingdom