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The aim of this prospective randomized controlled double-blinded study is to compare the efficacy of dexmedetomidine, MgSO4 and lidocaine for cough suppression during general anesthetic emergence as regard number and severity.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Dexmedetomidine group ( D group ) | Active Comparator | Patients will receive 0.5 μg/kg dexmedetomidine in 10 ml normal saline 10 min before the end of surgery. |
|
| Magnesium sulfate group ( M group ) | Active Comparator | Patients will receive 30 mg/kg IV magnesium sulfate 50% in 10 ml normal saline 10 min before the end of surgery. |
|
| Lidocaine group ( L group ) | Active Comparator | Patients will receive lidocaine 1.5 mg/kg lidocaine in 10 ml normal saline 10 min before the end of surgery. |
|
| Control group ( C group ) | Placebo Comparator | Patients will receive 10 ml normal saline 10 min before the end of surgery. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Dexmedetomidine | Drug | Patients will receive 0.5 μg/kg dexmedetomidine in 10ml normal saline 10 min before the end of surgery. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Cough suppression as regard number and severity. | Coughing severity will be classified using the 3 point scale described by Minogue et al.: 1 = mild, single cough, 2 = moderate (lasting for <5 seconds) cough, and severe (lasting for >5 seconds) cough. | at 0 and 10,20,30,40 minutes after endotracheal extubation. |
| Measure | Description | Time Frame |
|---|---|---|
| Intraoperative heart rate (HR). | Changes in Intraoperative heart rate. change in heart rate per minute (HR/minute) will be all measured from the patient's arrival at the operating room to the end of surgery. | at 15-minutes interval. |
| Intraoperative mean arterial blood pressure (MAP). |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Medhat H Allam, lecturer.MD | Contact | 1003012989 | +020 | Medhathelaly@gmail.com |
| Osama H Ahmed, Professor.MD | Contact | 1223460571 | +020 | DOCTOR_OSAMA_HELAL@hotmail.com |
| Name | Affiliation | Role |
|---|---|---|
| Mahmoud T Abd Elhafeez, Specialist.Mcs | mahmoud.talaat750@gmail.com | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Faculty of Medicine, Al-Azhar university Assiut, Egypt. | Recruiting | Asyut | 2091110 | Egypt |
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| ID | Term |
|---|---|
| D003371 | Cough |
| ID | Term |
|---|---|
| D012120 | Respiration Disorders |
| D012140 | Respiratory Tract Diseases |
| D012818 | Signs and Symptoms, Respiratory |
| D012816 | Signs and Symptoms |
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| ID | Term |
|---|---|
| D020927 | Dexmedetomidine |
| D008278 | Magnesium Sulfate |
| D008012 | Lidocaine |
| D000077330 | Saline Solution |
| ID | Term |
|---|---|
| D007093 | Imidazoles |
| D001393 | Azoles |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |
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| Magnesium sulfate | Drug | Patients will receive 30 mg/kg IV magnesium sulfate 50% 10 min before the end of surgery. |
|
|
| Lidocaine | Drug | Patients will receive lidocaine 1.5 mg/kg lidocaine 10 min before the end of surgery. |
|
| normal saline | Drug | Patients will receive 10 ml normal saline 10 min before the end of surgery. |
|
Changes in Intraoperative mean arterial blood pressure (MAP). change in mean arterial blood pressure (MAP) in mmHg will be all measured from the patient's arrival at the operating room to the end of surgery. |
| at 15-minutes interval. |
| Intraoperative arterial oxygen saturation (Spo2). | Changes in Intraoperative arterial oxygen saturation (Spo2%). change in arterial oxygen saturation (Spo2%). be all measured from the patient's arrival at the operating room to the end of surgery. | at 15-minutes interval. |
| Sedation score. | Sedation score will be recorded using the Ramsay sedation score (Ramsay et al., 1974). | at 0,10,20,30, and 40 minutes after tracheal extubation. |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D017616 |
| Magnesium Compounds |
| D007287 | Inorganic Chemicals |
| D013431 | Sulfates |
| D013464 | Sulfuric Acids |
| D013456 | Sulfur Acids |
| D013457 | Sulfur Compounds |
| D000083 | Acetanilides |
| D000813 | Anilides |
| D000577 | Amides |
| D009930 | Organic Chemicals |
| D000814 | Aniline Compounds |
| D000588 | Amines |
| D000077324 | Crystalloid Solutions |
| D007552 | Isotonic Solutions |
| D012996 | Solutions |
| D004364 | Pharmaceutical Preparations |