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This study aims to compare paravertebral block and thoracic epidural in awake thoracotomy.
Pain can often persist after thoracotomy, and the incidence of chronic pain is high, with studies revealing that 30% to 50% of patients still experience pain up to five years after surgery.
Thoracic epidural blockade (TEB) blocks nerves that supply the chest with local anesthetic bilaterally, at the spinal cord level. It acts by reducing the onward transmission of painful nerve signals, but may not abolish them altogether. Paravertebral blockade (PVB) involves injecting local anesthetic into the paravertebral space, which contains spinal nerves (and sometimes even extension of the dura), white and grey rami communicantes, the sympathetic chain, and intercostal vessels, on the side of surgery.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Thoracic epidural block group | Experimental | Patients will preoperatively receive an awake thoracic epidural block. |
|
| Paravertebral block group | Experimental | Patients will preoperatively receive a paravertebral block. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Thoracic epidural block | Other | Patients will preoperatively receive an awake thoracic epidural block. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Intraoperative fentanyl consumption | Additional bolus doses of fentanyl 0.5µg/kg will be given if the mean arterial blood pressure or heart rate rises above 20% of baseline levels. | Intraoperatively |
| Measure | Description | Time Frame |
|---|---|---|
| Time to the 1st rescue analgesia | Time to first request of rescue analgesia will be assessed from the end of surgery till first dose of morphine administrated. | 48 hours postoperatively |
| Mean arterial pressure |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Mohamed E Abdel Fattah, MD | Contact | 00201284475792 | mohamed-elsaid@cu.edu.eg |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Cairo University | Recruiting | Cairo | 12613 | Egypt |
The data will be available upon a reasonable request from the corresponding author after the end of study for one year.
After the end of study for one year.
The data will be available upon a reasonable request from the corresponding author.
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| Paravertebral block | Other | Patients will preoperatively receive a paravertebral block. |
|
Mean arterial pressure will be recorded at baseline, and every 15min till the end of surgery
| Till the end of surgery (Up to 2 hours) |
| Heart rate | Heart rate will be recorded at baseline, and every 15min till the end of surgery | Till the end of surgery (Up to 2 hours) |
| Total morphine consumption | If numeric rating scale (NRS)>3 at rest will be observed, rescue analgesia via IV morphine 3 mg boluses will be administered. | 48 hours postoperatively |
| Degree of pain | The patients will be instructed how to report pain by the numeric rating scale (NRS) [on a scale from (0 to 10), zero means no pain and ten means the worst pain]. NRS will be measured at post-anesthesia care unit (PACU), 1, 2, 4, 8, 12, 18, 24, 36, 48 hours postoperatively at rest and movement | 48 hours postoperatively |
| Degree of patient satisfaction | Degree of patient satisfaction will be assessed on a 5-point Likert scale patient satisfaction (1, extremely dissatisfied; 2, unsatisfied; 3, neutral; 4, satisfied; 5, extremely satisfied) | 48 hours postoperatively |
| Incidence of adverse events | Incidence of adverse events such as nausea, vomiting, respiratory depression, hypotension and bradycardia | 48 hours postoperatively |