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This study aims to compare the pharmacokinetics and bioavailability of crystalline glucosamine sulfate and regular glucosamine sulfate using a double-blind, randomized, crossover design.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Crystalline glucosamine sulfate | Experimental | Participants receive their treatment of crystalline glucosamine sulfate at a total dose of 1500 mg of glucosamine sulfate. Treatments are consumed with a glass of water followed by a standardized breakfast (diet-controlled condition). Capillary whole blood samples are collected at different time points up to 24 hours post-dose. A washout period of 1 week between each treatment is used. |
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| Regular glucosamine sulfate | Experimental | Participants receive their treatment of regular glucosamine sulfate at a total dose of 1500 mg of glucosamine sulfate. Treatments are consumed with a glass of water followed by a standardized breakfast (diet-controlled condition). Capillary whole blood samples are collected at different time points up to 24 hours post-dose. A washout period of 1 week between each treatment is used. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Crystalline glucosamine sulfate | Dietary Supplement | A maximum single dose of 1500mg of glucosamine sulfate in a caplet. |
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| Measure | Description | Time Frame |
|---|---|---|
| AUC: the area under the concentration-time curve | To determine the gastrointestinal absorption of orally ingested glucosamine sulfate in healthy adult volunteers and compare the Area under the plasma concentration versus time curve (AUC) with that of other capsules containing glucosamine sulfate. | 0 (baseline; pre-dose), 0.5, 1, 1.5, 2, 2.5, 3, 4, 5, 6, 12, 24 hours (post-dose) |
| Cmax: maximum plasma concentration | To determine the gastrointestinal absorption of orally ingested glucosamine sulfate in healthy adult volunteers and compare the peak plasma concentration (Cmax) with that of other capsules containing glucosamine sulfate. | 0 (baseline; pre-dose), 0.5, 1, 1.5, 2, 2.5, 3, 4, 5, 6, 12, 24 hours (post-dose) |
| Tmax: the time point of maximum plasma concentration | To determine the gastrointestinal absorption of orally ingested glucosamine sulfate in healthy adult volunteers and compare the time point of maximum plasma concentration (Tmax) with that of other capsules containing glucosamine sulfate. | 0 (baseline; pre-dose), 0.5, 1, 1.5, 2, 2.5, 3, 4, 5, 6, 12, 24 hours (post-dose) |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| ISURA | Burnaby | British Columbia | Canada |
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| Regular glucosamine sulfate | Dietary Supplement | A maximum single dose of 1500mg of glucosamine sulfate in hard gel capsules. |
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