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This prospective multicenter observational study, conducted between June , 2022, and April, 2023, is a preplanned analysis of the AMESI study titled 'Demographics, diagnosis, management, and outcomes of non-occlusive mesenteric ischemia,' aiming primarily to describe the demographic profile, clinical presentation, and laboratory findings of patients with non-occlusive mesenteric ischemia (NOMI), and secondarily to identify independent risk factors as well as diagnostic approaches, management strategies, and outcomes-including in-hospital, 90-day, and one-year results.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Patients with non-occlusive mesenteric ischemia | Patients with non-occlusive mesenteric ischemia, n=55 |
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| Patients with arterial occlusive mesenteric ischemia | Patients with arterial occlusive mesenteric ischemia, n=231 |
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| Patients with venous occlusive mesenteric ischemia | Patients with arterial occlusive mesenteric ischemia, n=73 |
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| Patients with unclear mechanism of acute mesenteric ischemia | Patients with unclear mechanism of acute mesenteric ischemia, n=48 |
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| Patients with suspected but not confirmed acute mesenteric ischemia | Patients with suspected but not confirmed acute mesenteric ischemia, n=159 |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| No intervention | Other | No intervention, this is an observational study on patients with suspected acute mesenteric ischemia |
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| Measure | Description | Time Frame |
|---|---|---|
| Demographic profile | One of the primary objectives is to describe the baseline demographic profile of patients with non-occlusive mesenteric ischemia. The demographic data will include the following information:
| Baseline |
| SOFA score | Sequential Organ Failure Assessment (SOFA) score. Range: 0-24. Higher scores indicate more severe organ dysfunction. | Baseline |
| Serum Lactate Levels in Patients with Non-Occlusive Mesenteric Ischemia | Serum lactate level measured in mmol/L. Higher values indicate worse tissue perfusion. | Baseline |
| Baseline APACHE II Score | Acute Physiology and Chronic Health Evaluation II (APACHE II) score. Range: 0-71. Higher scores indicate more severe disease and higher predicted mortality. | Baseline |
| Arterial Blood pH in Patients with Non-Occlusive Mesenteric Ischemia | Arterial pH level. Normal range is 7.35-7.45. Lower values indicate acidosis. | Baseline |
| Measure | Description | Time Frame |
|---|---|---|
| Rate of Patients Diagnosed with Non-Occlusive Mesenteric Ischemia by CT, Endoscopy, or Angiography | Percentage of participants diagnosed with non-occlusive mesenteric ischemia (NOMI) using computed tomography (CT), endoscopy, or angiography. | Baseline |
| Management |
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Inclusion Criteria:
All at least 18-year-old patients with acute mesenteric ischemia or patients suspected of acute mesenteric ischemia that was not confirmed
Exclusion Criteria:
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Study groups
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Tartu | Tartu | 50090 | Estonia |
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| Type | Includes Protocol | Includes SAP | Includes ICF | Document Label | Document Date | Document Uploaded Date | Document File Name |
|---|---|---|---|---|---|---|---|
| Prot_SAP | Yes | Yes | No | Study Protocol and Statistical Analysis Plan | Apr 18, 2025 | Apr 26, 2025 | Prot_SAP_000.pdf |
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Rate of surgical, conservative, endovascular or palliative management |
| Baseline |
| 30-day survival | 30-day Survival of patients with non-occlusive mesenteric ischemia | 30 days after admission |
| 1-year survival | 1-year survival of patients with non-occlusive mesenteric ischemia | 1 year |