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| ID | Type | Description | Link |
|---|---|---|---|
| R01DC011742 | U.S. NIH Grant/Contract | View source |
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| Name | Class |
|---|---|
| University of Iowa | OTHER |
| National Institutes of Health (NIH) | NIH |
| National Institute on Deafness and Other Communication Disorders (NIDCD) | NIH |
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The goal of this clinical trial is to determine how memory and attention affect the ability of children with developmental language disorder (DLD) to learn and use new vocabulary.
The goal of this clinical trial is to determine how memory and attention affect the ability of children with developmental language disorder (DLD) to learn and use new vocabulary.
Aims 1-3 include children with DLD and healthy children with typical language development. The general hypothesis is that the memory and attention challenges that characterize DLD, but not healthy development, affect the robustness of word learning. Aim 4 includes healthy children only to simulate the cascading effects of weak word learning on the broader linguistic system. The main questions this clinical trial aims to answer are:
What is the role of linguistic long-term memory in children's ability to hold new verbal information in short-term memory? What is the role of attention in children 's ability to hold new verbal information in short-term memory? What are the cascading effects of short-term verbal memory problems on the integrity of the language system?
In Aim 1a, researchers will compare syllable repetitions when those syllables do or do not have English-like prosody and do or do not have meaning to see if knowledge of prosody and word meaning supports accurate short-term memory.
In Aim 1b, researchers will compare the repetition of adjectives and nouns when those words do or do not have English-like grammar (i.e., when they are presented as adjective + noun rather than noun + adjective) to see if knowledge of word order supports accurate short-term memory.
In Aim 2, researchers will compare the syllable repetitions when those syllables are presented with or without attention cues and with or without a delay of 500msec between presentation and response to see if attention facilitates accurate short-term memory. The delay condition is intended to increase load on short-term memory.
In Aim 3, all measures are observational. The researchers will assess the child's long-term memory of language, attention skills, and verbal short-term memory to see if children with DLD but good attention skills are able to perform well on short-term memory tasks.
In Aim 4, researchers will compare the ability of children to comprehend newly learned words that are taught via active retrieval or passive study. Active retrieval yields more robust learning, and passive study yields weaker learning. The goal is to compare how well children use those newly learned words to recall semantic category information (e.g., was it a bug or a bird) and comprehend sentences to see if the weak word learning has cascading impacts beyond learning the word itself.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Prosody | Experimental | In Aim 1a, the syllables to be repeated are presented with English-like prosody or list-like prosody. |
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| Meaning | Experimental | In Aim 1a, the syllables to be repeated will have meaning (e.g., neck) or no meaning (e.g., ba). |
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| Grammar | Experimental | In Aim 1b, the syllables to be repeated are English adjectives and nouns. They will be presented to obey English grammar (e.g., happy pencil) or not (e.g., pencil happy). |
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| Attention | Experimental | In Aim 2, the syllables to be repeated will be presented in the 'baseline' condition or an 'attention-grabbing' condition. The attention grabbers are a reduction in the audio signal of 10dB (so that the child must listen carefully) and a visual cue (a cartoon character with large ears to cue listening carefully). |
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| Encoding | Experimental | In Aim 4, new words will be learned from instruction that involves active practice (high encoding condition) or passive study (low encoding condition). |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Supportive learning | Behavioral | All interventions are manipulations to the stimuli that the child hears with the goal of discovering which manipulations support verbal learning. |
| Measure | Description | Time Frame |
|---|---|---|
| Accuracy of Syllable Repetition | Number of syllables pronounced correctly. | Day 1 |
| Accuracy of Word Comprehension | Number of correct answers on a 4-alternative-forced-choice word comprehension probe. | Day 2 |
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Inclusion Criteria:
Exclusion Criteria
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Principal Investigator | Contact | 531-355-5068 | karla.mcgregor@boystown.org | |
| Lab Manager | Contact | 531-355-5096 | margo.appenzeller@boystown.org |
| Name | Affiliation | Role |
|---|---|---|
| Karla McGregor, Ph.D. | Boystown National Research Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Boys Town National Research Hospital | Recruiting | Omaha | Nebraska | 68131 | United States |
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| ID | Type | URL | Comment |
|---|---|---|---|
| Study Protocol | View IPD |
The study team will share research data generated and metadata and descriptors. The purpose is to make shared data meaningful and usable by other researchers. The data will be behavioral data generated from clinical measures and behavioral experiments. The data will consist of numbers (e.g., accuracy levels, scores), demographic descriptors (e.g., age and sex), and audio files of children's repetitions of word- and nonword syllables. De-identified, individual-level raw data will be shared publicly. Audio files will be shared under a data agreement only.
The start date is 2-20-2026. The end date is 50 years later.
To maximize the benefits of data sharing, the team will share data as broadly as possible to the extent consistent with applicable laws, regulations, rules, and policies. Anyone, including members of the general public, will have access to all of the de-identified data in the form of numbers (e.g., test scores). No video files will be shared. Audio files will be shared with those who qualify and seek permission via a data-sharing agreement. The data-sharing agreement provides for (1) a commitment to using the data only for research purposes and not to identify any individual participant; (2) a commitment to securing the data using appropriate computer technology; and (3) a commitment to destroying or returning the data after analyses are completed. The publicly available data and the data sharing agreement will be accessible in a public-facing Collection in Open Science Framework (osf.io).
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| ID | Term |
|---|---|
| D007805 | Language Development Disorders |
| ID | Term |
|---|---|
| D007806 | Language Disorders |
| D003147 | Communication Disorders |
| D019954 | Neurobehavioral Manifestations |
| D009461 | Neurologic Manifestations |
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| ID | Term |
|---|---|
| D020935 | MAP Kinase Signaling System |
| ID | Term |
|---|---|
| D015398 | Signal Transduction |
| D001669 | Biochemical Phenomena |
| D055598 | Chemical Phenomena |
| D053858 | Metabolic Networks and Pathways |
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Aims 1 and 2 are single group interventions. Aim 3 is not an intervention. Aim 4 is a parallel intervention.
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| Cascades | Behavioral | The intervention is a manipulation of word instruction with the goal of discovering whether weaker word learning results in cascading effects on semantic category memory and sentence comprehension. |
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| D009422 | Nervous System Diseases |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D008660 | Metabolism |
| D002468 | Cell Physiological Phenomena |