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This study aims to evaluate changes in perfusion index (PI) in pediatric patients undergoing elective surgery under low-flow anesthesia. PI will be monitored at multiple intraoperative and postoperative time points to assess its relationship with hemodynamic stability and depth of anesthesia. The study will also investigate whether low-flow anesthesia affects the incidence of emergence agitation (EA). Patients will be assigned to either low-flow or normal-flow anesthesia groups based on routine clinical practice. No intervention will be applied beyond standard care. The findings are expected to provide insight into the predictive value of PI in postoperative recovery and support safer anesthesia practices in pediatric populations.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Low-Flow Anesthesia Group (LFA) | Experimental | Patients will receive general anesthesia using a fresh gas flow rate of 1 L/min (50% Oâ‚‚ + 50% air). Perfusion index and hemodynamic parameters will be monitored at predetermined time points. |
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| Normal-Flow Anesthesia Group (HFA) | Active Comparator | Patients will receive general anesthesia using a fresh gas flow rate of 2 L/min (50% Oâ‚‚ + 50% air). Perfusion index and hemodynamic parameters will be monitored at the same time points. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Low-Flow Anesthesia (LFA) | Procedure | General anesthesia with a fresh gas flow rate of 1 L/min (50% oxygen + 50% air). |
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| Measure | Description | Time Frame |
|---|---|---|
| Change in Perfusion Index (PI) | Perfusion Index (PI) will be measured at 11 predefined perioperative time points to assess its intraoperative variation and its potential correlation with anesthesia depth and emergence profile in pediatric patients undergoing low-flow vs normal-flow anesthesia. | From induction to 30 minutes after extubation |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| ilke dolgun | Contact | +905555485632 | ilkeser2004@gmail.com |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Istinye Üniversity | Recruiting | Istanbul | Merkez Mahallesi | 34250 | Turkey (Türkiye) |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 27569026 | Result | Krishnamohan A, Siriwardana V, Skowno JJ. Using a pulse oximeter to determine clinical depth of anesthesia-investigation of the utility of the perfusion index. Paediatr Anaesth. 2016 Nov;26(11):1106-1111. doi: 10.1111/pan.13000. Epub 2016 Aug 28. | |
| Result | RYALINO, CHRISTOPHER, et al. Low-flow anesthesia technique reduces emergence agitation in pediatric patients underwent general anesthesia. Asian Journal of Pharmaceutical and Clinical Research, 2019, 12.5: 139-41. | ||
| 24092509 |
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ediatric patients undergoing elective surgery will be followed in two naturally assigned groups based on anesthesia flow rate: low-flow (LFA) and normal-flow (HFA). No intervention will be applied outside routine clinical care, and all data will be collected through perioperative monitoring.
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Group allocation is determined by the anesthesia provider during routine care. Both the participant and the outcome assessor are blinded to group assignment. Data analysis is performed without group identifiers.
| Result |
| Kowalczyk M, Fijalkowska A, Nestorowicz A. New generation pulse oximetry in the assessment of peripheral perfusion during general anaesthesia - a comparison between propofol and desflurane. Anaesthesiol Intensive Ther. 2013 Jul-Sep;45(3):138-44. doi: 10.5603/AIT.2013.0029. |