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The main goal is to elucidate the mechanistic coupling between inflammation and the ability to maintain skeletal muscle through physical exercise while hospitalized. We will investigate protein kinetics in patients who belong to one of three groups 1) high inflammatory state, 2) moderate inflammatory state and 3) low/no inflammation. We will further intervene in group 1 (high inflammatory state) with anti-inflammatory nutrition (primarily green-solution plant-based) to diminish activity in inflammatory pathways. The hypothesis is that inflammation will inhibit protein synthesis in skeletal muscle both in resting muscle and in strength trained skeletal musculature, and that a lowering of the inflammatory status by anti-inflammatory nutrition will enhance the exercise induced formation of new muscle mass. .
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Anti-inflammatory diet and supplements | Experimental | A sub group of patients with high inflammation will be offered a diet where 50% of the regular hospital diet is switched for diet containing plant based food and nutrients found to lower inflammation |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Single leg training | Other | All subjects will train one leg twice daily. |
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| Measure | Description | Time Frame |
|---|---|---|
| FSR in high vs. low inflammation group | The primary outcome is the muscle protein fractional synthesis rate (FSR) in the high inflammation group vs. the low inflammation group | 7 days (or until hospital discharge) |
| Measure | Description | Time Frame |
|---|---|---|
| Change in muscle size between groups | Change in muscle size during the study period between the three groups | 7 days (or until hospital discharge) |
| FSR in trained vs. non trained leg | Effect of training on the muscle protein fractional synthesis rate |
| Measure | Description | Time Frame |
|---|---|---|
| Feasibility of training | It will be reported if the subjects can complete a minium of 80% of the twice-daily training sessions. | 7 days (or until hospital discharge) |
Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Bispebjerg Hospital | Copenhagen | 2400 | Denmark |
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| 7 days (or until hospital discharge) |
| Inflammation in regular vs. antiinflammatory diet | Comparison of the changes in plasma C-Reactive Protein (CRP) from day 1 till discharge between the group ingesting regular diet vs. the group ingesting an anti-inflammatory diet. | 7 days (or until hospital discharge) |
| AA uptake following feeding | Plasma amino acid profile following a standard meal | 7 days (or until hospital discharge) |
| Muscle size in trained vs. untrained leg | The difference in muscle size in trained vs. untrained leg measured using ultrasound | 7 days (or until hospital discharge) |
| Change in muscle strength between groups | Description: Change in muscle strength during the study period between the three groups. Hand muscle strength is measured using a hand dynamometer, and leg muscle strength (MVC) is measured using an isokinetic dynamometer. Time Frame: 7 days (or until hospital discharge) | 7 days (or until discharge) |
| Muscle strength in trained vs. untrained leg | The difference in leg muscle strength (MVC) in trained vs. untrained leg measured using an isokinetic dynamometer. | 7 days (or until hospital discharge) |