The Impact of Inflammation on Skeletal Muscle Maintenance in Hospitalized Patients

The Impact of Inflammation on Skeletal Muscle Maintenance in Hospitalized Patients

The main goal is to elucidate the mechanistic coupling between inflammation and the ability to maintain skeletal muscle through physical exercise while hospitalized. We will investigate protein kinetics in patients who belong to one of three groups 1) high inflammatory state, 2) moderate inflammatory state and 3) low/no inflammation. We will further intervene in group 1 (high inflammatory state) with anti-inflammatory nutrition (primarily green-solution plant-based) to diminish activity in inflammatory pathways. The hypothesis is that inflammation will inhibit protein synthesis in skeletal muscle both in resting muscle and in strength trained skeletal musculature, and that a lowering of the inflammatory status by anti-inflammatory nutrition will enhance the exercise induced formation of new muscle mass. .

Inclusion Criteria:

• Hospitalised at the geriatric department at Bispebjerg Hospital with an expected admission time of minimum 7 days
• Have Disease Related Malnutrition (DRM)
• Able to carry out strength training
• Able to understand the study information, as assessed by the research team

Exclusion Criteria:

• Current use of anti-inflammatory medication
• Liver failure
• Short bowel syndrome
• Chrohn's or colitis
• Terminally ill