The study was proactively suspended to ensure alignment with all applicable regulatory filing procedures. This decision was made to maintain adherence to institutional and compliance standards prior to study initiation.

The application of lidocaine cream on oral secretions of LMA removal during the recovery period in ophthalmic surgical patients under general anesthesia: a randomized controlled trial

During the recovery from general anesthesia, patients commonly experience heightened oral secretions, which can elevate intraocular pressure (IOP) due to coughing and potentially lead to the infiltration of secretions into the surgical site via the nasolacrimal duct, increasing the risk of endophthalmitis. This study is aimed to investigate whether applying lidocaine cream to the laryngeal mask airway (LMA) reduces oral secretions during emergence from general anesthesia in ophthalmic surgery patients.

Inclusion Criteria:

• Aged 18 to 60 years;
• With American Society of Anesthesiologists (ASA) physical status I or II;
• Scheduled to undergo ophthalmic surgery following general anesthesia with LMA.

Exclusion Criteria:

• Contraindications to LMA use;
• A history of upper respiratory tract infection within one week prior to surgery;
• Persistent pharyngeal symptoms (eg. throat irritation, dryness, or chronic cough, etc.) lasting ≥ 3 months;
• Severe gastroesophageal reflux disease;
• Morbid obesity, defined as a body mass index ≥ 40 kg/m2;
• A predicted difficult airway (eg. a history of difficult airway, mouth opening < 3 cm, Mallampati class 4, limited neck extension or cervical spine disease);
• Presence of structural abnormalities, masses, infections, or scarring in the oral cavity or oropharynx;
• Known contraindications to lidocaine cream;
• Two or more failed attempts at LMA insertion;
• Intraoperative administration of anticholinergic agents;
• Any other condition present likely to influence the study outcomes.