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| ID | Type | Description | Link |
|---|---|---|---|
| FWOAL1107 | Other Grant/Funding Number | Fund for Scientific Research, Flanders, Belgium |
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| Name | Class |
|---|---|
| Fund for Scientific Research, Flanders, Belgium | OTHER |
| Vrije Universiteit Brussel | OTHER |
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First the investigators will examine if the blood flow in the brain is different in patients with Multiple Sclerosis compared to healthy volunteers.
HOW?
- The blood flow of the subjects is imaged by use of a special MRI-technique.
Secondly, the investigators will examine if the blood flow can determine disease progression.
HOW? - Multiple Sclerosis patients are asked for a follow-up visit after two years.
The main goal is to understand the effect of transcranial Direct Current Stimulation (tDCS) on the cerebral blood flow.
HOW?
- Participants get two session of tDCS. Before, during and after stimulation MRI scans are performed.
Comparison of CBF between healthy volunteers and MS patients:
- Arterial spin labelling (ASL) is used to investigate cerebral blood flow in patients with MS and healthy volunteers.
The effect of transcranial direct current stimulation (tDCS) on cerebral blood flow:
Follow-up visit:
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Sham-first tDCS | Other | The sham-first group will receive: Sham stimulation in visit 1, Active stimulation in visit 2 |
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| Active-first tDCS | Other | The active-first group will receive: Active stimulation in visit 1, Sham stimulation in visit 2 |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| transcranial Direct Current Stimulation | Device | Stimulation intensity: Variable (between 1 mA and 2 mA), Electrode placement: Dorsolateral prefrontal cortex, Duration: 10 minutes |
| Measure | Description | Time Frame |
|---|---|---|
| Cerebral blood flow (CBF) | Measure of brain perfusion. CBF is measured at baseline and after two years. Additionally, the investigators will measure CBF before-, during-, and after tDCS. | Visit 1 (baseline), visit 2 (+-1 week after visit 1), visit 3 (2 years after visit 1) |
| Measure | Description | Time Frame |
|---|---|---|
| Symbol Digit Modalities Test (SDMT) | Measure of information processing speed | Baseline and after 2 years |
| California Verbal Learning Test (CVLT-II) | Measure of verbal memory |
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Inclusion criteria - MS patient
Exclusion criteria - MS patient
Inclusion criteria - Healthy Volunteer
• Age ≥ 18
Exclusion criteria - Healthy Volunteer
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Kristien Cool, Master in Biomedical Sciences | Contact | +32468545398 | kristien.cool@vub.be |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University hospital of Brussels | Brussels | 1090 | Belgium |
We will not share individual participant data. As we collect personal data on people with multiple sclerosis, we share data on request and after signing a data sharing agreement between both parties. This ensures proper usage and interpretation of the results.
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| ID | Term |
|---|---|
| D009103 | Multiple Sclerosis |
| ID | Term |
|---|---|
| D020278 | Demyelinating Autoimmune Diseases, CNS |
| D020274 | Autoimmune Diseases of the Nervous System |
| D009422 | Nervous System Diseases |
| D003711 | Demyelinating Diseases |
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| ID | Term |
|---|---|
| D065908 | Transcranial Direct Current Stimulation |
| ID | Term |
|---|---|
| D004599 | Electric Stimulation Therapy |
| D013812 | Therapeutics |
| D003295 | Convulsive Therapy |
| D013000 | Psychiatric Somatic Therapies |
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| Baseline and after 2 years |
| Controlled Oral Word Association Test (COWAT) | Measure of verbal fluency | Baseline and after 2 years |
| Brief visuospatial Memory Test (BVMT-R) | Measure of spatial memory | Baseline and after 2 years |
| Fatigue Scale for Motor and Cognitive Function (FSMC) | Measure of fatigue | Baseline and after 2 years |
| Beck's depression inventory (BDI) | Measure of depression | Baseline and after 2 years |
| MRI T1 scan | Cortical volume, volumes of white matter and deep grey matter | Baseline and after 2 years |
| MRI T2 FLAIR scan | Lesion load, lesion volume | Baseline and after 2 years |
| National MS Center Melsbroek | Melsbroek | 1820 | Belgium |
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| D001327 | Autoimmune Diseases |
| D007154 | Immune System Diseases |
| D004191 | Behavioral Disciplines and Activities |
| D004597 | Electroshock |
| D011580 | Psychological Techniques |