This study aims to better understand Alzheimer's disease by looking at brain scans, specifically MRI images, to detect early signs of brain changes linked to the disease. Researchers are focusing on the hippocampus, a part of the brain that shrinks in people with Alzheimer's. The study will also explore other brain changes that often happen alongside hippocampal shrinkage. By analyzing these brain images, the study hopes to find ways to diagnose Alzheimer's earlier and more accurately using advanced imaging techniques.

Inclusion Criteria:

• Patients who underwent a brain MRI (3D T1 Bravo and Cube FLAIR sequences) between January 2018 and June 2022.
• Diagnosis of Alzheimer's disease (for the Alzheimer group).
• No neurological disease for control group participants.
• Complete clinical and biological assessments available.
• Quality imaging without motion artifacts.

Exclusion Criteria:

• Incomplete clinical or radiological data.
• Poor image quality (e.g., motion artifacts).
• Presence of other neurodegenerative or psychiatric disorders.

Participants will be selected from a retrospective cohort of patients who underwent brain MRI scans (3D T1 Bravo and Cube FLAIR sequences) between January 2018 and June 2022. The study population includes two groups: patients diagnosed with Alzheimer's disease based on clinical and biological assessments, and cognitively healthy individuals with no history of neurological or psychiatric disorders, serving as controls.