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| Name | Class |
|---|---|
| Azienda Ospedaliera di Padova | OTHER |
| University of Padova | OTHER |
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The current study evaluates first the assumption that eye-movements during free viewing behavior are potential biomarkers of visuospatial deficits in stroke population. Second, it assesses the feasibility of a novel visual exploration training to ameliorate visuospatial deficits, by exploiting an auditory biofeedback system coupled with online parsed fixations.
This study is divided into two parts concerning the diagnostic and treatment of visuospatial deficits in patients affected by unilateral stroke. Eye movements indices during free viewing of natural scenes will be correlated to the standard neuropsychological evaluation, describing the cognitive, motor and functional spectrum of patient status. Moreover, functional and structural neuroimaging will be exploited to identify neural correlates of patient eye movements characteristics. Ultimately, a subsample of randomly assigned participants, at the IRCCS San Camillo, will undergo a novel visual exploration training, in addition to the standard rehabilitation. This protocol consists of natural scene exploration guided by an auditory biofeedback system which tracks online parsed fixations. Concretely, the training maneuvers exploration toward salient regions of the presented image, as indicated by a normative sample. Changes in free viewing behavior, neuropsychological assessment and neuroimaging will be discussed compared to an active control group and a healthy sample.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Intervention | Experimental | This group will undergo ten sessions of the experimental visual exploration protocol and the standard neuropsychological rehabilitation delivered in the clinical facility |
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| Control | Active Comparator | This group will undergo the standard neuropsychological rehabilitation at the IRCCS San Camillo hospital |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Visual exploration training | Behavioral | Visual exploration of natural scenes guided by closed-loop auditory biofeedback through eye-tracking |
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| Measure | Description | Time Frame |
|---|---|---|
| Change pre-post rehabilitation in eye movements patterns during free viewing | Eye movements patterns described by fixations, saccades and blinks related features summarized by principal component analysis (PCA) | At day 0 and day 30 (i.e., end of the rehabilitation) |
| Change pre-post rehabilitation in Behavioral Inattention Test score | Neuropsychological test assessing visuospatial deficits | At day 0 and day 30 (i.e., end of the rehabilitation) |
| Change pre-post rehabilitation in Trail Making Test score | Neuropsychological test assessing visuospatial abilities, scored as the time to complete the task | At day 0 and day 30 (i.e., end of the rehabilitation) |
| Change pre-post rehabilitation in Posner Test reaction times | Neuropsychological test assessing visuospatial abilities, scored with the measured reaction times | At day 0 and day 30 (i.e., end of the rehabilitation) |
| Change pre-post rehabilitation in Attention Matrices Test | Neuropsychological test assessing visuospatial deficits | At day 0 and day 30 (i.e., end of the rehabilitation) |
| Change pre-post rehabilitation in Brief Visuospatial Memory Test Revised | Neuropsychological test assessing visuospatial memory | At day 0 and day 30 (i.e., end of the rehabilitation) |
| Change pre-post rehabilitation in Bells Test |
| Measure | Description | Time Frame |
|---|---|---|
| Change pre-post rehabilitation in structural and functional connectivity | Structural and functional MRI connectivity maps | At day 0 and day 30 (i.e., end of the rehabilitation) |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Marco Zorzi | Contact | +39 049 827 6618 | marco.zorzi@unipd.it |
| Name | Affiliation | Role |
|---|---|---|
| Marco Zorzi | San Camillo IRCCS, Venice, Italy | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Azienda Ospedaliera di Padova | Recruiting | Padova | PD | Italy |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 21975780 | Background | Pollock A, Hazelton C, Henderson CA, Angilley J, Dhillon B, Langhorne P, Livingstone K, Munro FA, Orr H, Rowe FJ, Shahani U. Interventions for disorders of eye movement in patients with stroke. Cochrane Database Syst Rev. 2011 Oct 5;(10):CD008389. doi: 10.1002/14651858.CD008389.pub2. |
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| ID | Term |
|---|---|
| D020521 | Stroke |
| ID | Term |
|---|---|
| D002561 | Cerebrovascular Disorders |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
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| Standard neuropsychological rehabilitation | Behavioral | Standard rehabilitation delivered at the IRCCS San Camillo hospital |
|
Neuropsychological test assessing visuospatial deficits |
| At day 0 and day 30 (i.e., end of the rehabilitation) |
| Change pre-post rehabilitation in Apple Test score | Neuropsychological test assessing visuospatial deficits | At day 0 and day 30 (i.e., end of the rehabilitation) |
| Change pre-post rehabilitation in Comb and Razor Test | Neuropsychological test assessing functional activities to investigate spatial attention deficits | At day 0 and day 30 (i.e., end of the rehabilitation) |
| Change pre-post rehabilitation in Mental Number Interval Bisection | Neuropsychological test investigating spatial biases in the mental number line | At day 0 and day 30 (i.e., end of the rehabilitation) |
| Change pre-post rehabilitation in Anosognosia | Neuropsychological test investigating deficits awareness | At day 0 and day 30 (i.e., end of the rehabilitation) |
| Change pre-post rehabilitation in Load Test | Neuropsychological test assessing spatial attentional deficits with cognitive load as a moderator | At day 0 and day 30 (i.e., end of the rehabilitation) |
| Change pre-post rehabilitation in the Catherine-Bergego Scale score | Test assessing activities of daily living involving spatial attention | At day 0 and day 30 (i.e., end of the rehabilitation) |
| IRCCS San Camillo | Recruiting | Venice-Lido | VE | Italy |
|
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |