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The goal of this study is to identify new markers to predict the risk of developing cancer, primarily breast cancer. For this purpose, researchers will compare data obtained from cancer patients and healthy individuals. If characteristic differences are identified, e.g. in biomarkers, life style or family history, this may indicate a person's increased risk of developing cancer.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Case group (subjects with known pre-existing or current cancer diagnosis) | Other | The case group will consist of subjects with a known pre-existing or current cancer diagnosis, including breast cancer, lung cancer, colorectal cancer or gynecologic cancer |
|
| Control group (healthy subjects) | Other | The control group will consist of healthy subjects with no history of cancer |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Biomaterial collection | Other | All subjects will be asked to provide biomaterial (blood or saliva) for bio marker screening and analysis. Additional biomaterial (breath, urin, stool) is optional. |
| Measure | Description | Time Frame |
|---|---|---|
| Assessment of breast cancer risk by polygenic risk score in combination with app-based self-reported health behavior in the study population | Polygenic cancer risk score (PRS) as a numeric value using BOADICEA/CanRisk as absolute 10-year breast cancer risk and as relative risk compared with avarage women at the same age | Baseline |
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Inclusion Criteria:
Biological adult (at least 18 years old) women
Written informed consent for study participation and processing of personal data
Own smartphone that can run the BayPass mobile application and willingness to use said smartphone for study purposes
Additional inclusion criterion for case group:
Pre-existing or current diagnosis of at least one of the following oncological diseases: breast cancer, lung cancer, colorectal cancer, gynecologic cancer (incl. ovarian cancer, endometrial cancer, cervical cancer, fallopian tube cancer, vaginal cancer and vulvar cancer)
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Peter A. Fasching, Prof. Dr. med. | Contact | +49 9131 85 33572 | fk-digionko@uk-erlangen.de | |
| Hanna Hübner, PD Dr. rer. nat. | Contact | fk-digionko@uk-erlangen.de |
| Name | Affiliation | Role |
|---|---|---|
| Matthias W. Beckmann, Prof. Dr. med. | Head of Department of Obstetrics and Gynecology | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| DigiOnko Präventionsmobil | Recruiting | Please Refer to Project Homepage For Details (see Link Below) | Bavaria | Germany |
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| Label | URL |
|---|---|
| On this project homepage you can check where the next stop of the DigiOnko Präventionsmobil will be | View source |
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| ID | Term |
|---|---|
| D001943 | Breast Neoplasms |
| D008175 | Lung Neoplasms |
| D015179 | Colorectal Neoplasms |
| ID | Term |
|---|---|
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
| D001941 | Breast Diseases |
| D012871 | Skin Diseases |
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| BayPass mobile application | Other | All subjects will be asked to use the study-specific mobile application "BayPass" to complete questionnaires and provide results from screening examinations over a course of 12 months. |
|
| D017437 |
| Skin and Connective Tissue Diseases |
| D012142 | Respiratory Tract Neoplasms |
| D013899 | Thoracic Neoplasms |
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |
| D007414 | Intestinal Neoplasms |
| D005770 | Gastrointestinal Neoplasms |
| D004067 | Digestive System Neoplasms |
| D004066 | Digestive System Diseases |
| D005767 | Gastrointestinal Diseases |
| D003108 | Colonic Diseases |
| D007410 | Intestinal Diseases |
| D012002 | Rectal Diseases |