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Rupture of vulnerable carotid, vertebral, and intracranial arterial plaques results in thromboembolic stroke. Identification of these culprit lesions is an important component of post-stroke care. This study seeks to test the feasibility of NaF PET-CT to detect these plaques and alter patient care. Prior studies have shown a high degree of correlation between NaF PET+ lesions and high-risk plaque features on high resolution MRI, including mirocalcification, necrosis, and ulceration.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Intervention - NaF PET | Experimental | Intervention/Experimental Arm - non-cardiogenic thromboembolic stroke patients to undergo NaF PET-CT |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| NaF PET-CT | Drug | Following a non-cardiogenic thromboembolic stroke, patients will undergo NaF PET-CT imaging to identify the culprit plaque and any other vulnerable plaques at high risk for rupture |
| Measure | Description | Time Frame |
|---|---|---|
| Culprit lesion | Can NaF PET-CT within 14 days of a non-cardiogenic thromboembolic stroke identify the likely culprit plaque as a source of the stroke | Within 14 days of the stroke |
| Measure | Description | Time Frame |
|---|---|---|
| Recurrent stroke | Can NaF PET-CT within 14 days of a non-cardiogenic thromboembolic stroke predict the location of a future non-cardiogenic thromboembolic stroke | Within 1 year of imaging |
| Management change |
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Inclusion Criteria: 18 years of age or older with a non-cardiogenic thromboembolic stroke in the past 14 days.
Exclusion Criteria: Less than 18 years of age, any other kind of stroke, not clinically stable to undergo PET-CT
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Overlook Medical Center | Summit | New Jersey | 07901 | United States |
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Can NaF PET-CT within 14 days of a non-cardiogenic thromboembolic stroke alter patient management
| Within 1 year of imaging |