The purpose of the project is to assess the efficacy of parietal transcranial magnetic stimulation in misophonia. N=60 participants will undergo two transcranial magnetic stimulation sessions: one inhibitory and another excitatory. During both sessions, the parietal region will be stimulated. Participants will perform computerized tasks immediately before and after the stimulation, while EEG, heart rate, and skin temperature will be recorded. These recordings will be used to assess if TMS can be used to improve tolerance to misophonia triggers.

Inclusion Criteria:

• Hypersensitive to presence of a specific sound, which may be accompanied by irritation, anger/outbursts, or fear.
• Must be between the ages of 18 - 55.
• Must be fluent in English since the study's instructions, surveys, and tasks will be in English.

Exclusion Criteria:

• Epilepsy or previous episode of convulsion or seizure.
• Previous episode of fainting spell or syncope.
• Head trauma.
• Hearing problems.
• Cochlear implant.
• Metal in the brain, skull, or anywhere else in the body (e.g., splinters, fragments, clips, etc.).
• Implanted neurostimulator (e.g., DBS, epidural/subdural, VNS).
• Presence of cardiac pacemaker or intracardiac lines.
• Presence of medication infusion device.
• Use of pro-convulsant or epileptogenic medications.
• Pregnancy. The risks associated with TMS exposure during gestation have not been studied extensively. We wish to safeguard the health of potential participants and their children.
• Lactation. The risks associated with TMS during lactation and its effects on infant development have not been studied. We wish to safeguard the health of potential participants and their children.
• Presence of Mania, Psychosis, Antisocial Personality Disorder, Borderline Personality Disorder, and Suicidal Ideation.

All of the individual participant data collected during the trial, after deidentification.

Immediately following publication. No end date.

Researchers who provide a methodologically sound proposal.

To achieve aims in the approved proposal.

Proposals should be directed to parul.jain@mssm.edu. To gain access, data requestors will need to sign a data access agreement. Data are available for 5 years at a third party website (to be determined).

This is a TMS study. Only the technician administering TMS will be unblinded. All parties will be blinded till the end of the study. The technician is not involved in the data analysis.