Hip fracture is a common and severe disease in elderly patients. The question of the study is whether elderly patients with severe osteopenia have significantly lower levels of the collagen-binding protein Hsp47 than relatively mobile patients due to advanced immobility before the fracture, and whether they participants have a similar risk of VTE to the normal population despite having had a hip fracture and surgery.

In this study, the investigators aimed to prospectively measure the Hsp 47 gene expression levels in patients scheduled for surgery due to intertrochanteric femur fracture and healthy volunteers in the same age group and compare the results with the literature.

Also the complications prior or after surgery will be compared.

Inclusion Criteria:

• >65 years of age
• Interthrocanteric femur fracture AO Type 31A1, 31A2, 31A3
• Patients treated proksimal femoral nail
• Minor trauma
• Fracture mobility score 1,2,3,4,5
• Inial thrombocytes count 150.000-450.000 /µL

Exclusion Criteria:

• Body mass index >40
• Fracture mobility score 6 (unknown type)
• stage 4 chronic kidney disease
• Patients with rheumatological diseases
• Patients at serious risk of VTE(Venous thromboembolism) (according to the International Society on Thrombosis and Hemostasis, categorization of venous thromboembolism) :
• Active Hematologic Cancer
• Antiphospholipid syndrome
• History of recurrent thrombosis (DVT)
• Paroxysmal nocturnal hemoglobinuria