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| Name | Class |
|---|---|
| Daqing Oil Field Hospital | OTHER |
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This is an observational study tracking families and offspring of three cohorts from the 1986 Da Qing study: newly diagnosed diabetes, impaired glucose tolerance, and normoglycemia groups. Based on the original participants, the study will further include their spouses, first to third-generation offspring, and spouses of the offspring. General demographic information will be collected, and anthropometric measurements will be refined. A structured questionnaire will be used to gather disease history, family history of diabetes, and related information. Comprehensive diabetes-related laboratory screening and complication assessments will be conducted. A standardized biobank will be established, including blood and urine samples from the Da Qing Offspring Study, to support future research on epigenetics, metabolomics, and other mechanisms.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Lifestyle intervention subjects and offspring group | The subjects who received lifestyle intervention in the original Daqing Diabetes Prevention Study, their spouses, children 1 to 3, and spouses of their offspring were included in the study. |
| |
| Control group subjects and offspring | The subjects who did not received lifestyle intervention in the original Daqing Diabetes Prevention Study, their spouses, children 1 to 3, and spouses of their offspring were included in the study. |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Lifestyle interventions | Behavioral | Dietary intervention: 30kcal energy intake per kilogram of body weight per day, increase vegetable intake, control sugar and alcohol intake, encourage overweight and obese people to lose weight, lose 0.5-1kg per month until the weight reaches the target. Exercise intervention: Appropriate physical activity in spare time, 30-40 minutes per day, 5 times a week. |
| Measure | Description | Time Frame |
|---|---|---|
| Cumulative incidence rate of diabetes | This study statistically analyzed the cumulative incidence rate of diabetes at the end of the study through interview, medical record review, physical examination | Through study completion, an average of about 1.5 years |
| Measure | Description | Time Frame |
|---|---|---|
| weight | The subject's weight is recorded and the results are reported in kilograms. | Through study completion, an average of about 1.5 years |
| waist circumference | The subjects' waist circumference was recorded and the waist circumference results were reported in centimeters. |
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Inclusion Criteria:
Exclusion Criteria:
â–ªPeople who are unwilling to participate in this study
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Original subjects and spouses (70-90 years old), N=576+576=1152; First generation (50-70 years old), based on an average of 3 children per family, N=576*3=1728; The marriage rate of first generation is 90%, and the spouses N=1555; Second generation (25-45 years old), based on 90% of families having children, with an average of 1 child per family, N=1555*90%*1=1400; The marriage rate of second generation is 70%, and the spouses N=1400*70%=980; Third generation (1-20 years old), based on 80% of families having children, with an average of 1 child per family, N=980*80%*1=784; Based on the follow-up rate of 70%, the total number of people is about 5,000.
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| Name | Affiliation | Role |
|---|---|---|
| Liping Yu, Doctor | China-Japan Friendship Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| China-Japan Friendship hospital | Beijing | Beijing Municipality | 100029 | China |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 17098085 | Background | Lindstrom J, Ilanne-Parikka P, Peltonen M, Aunola S, Eriksson JG, Hemio K, Hamalainen H, Harkonen P, Keinanen-Kiukaanniemi S, Laakso M, Louheranta A, Mannelin M, Paturi M, Sundvall J, Valle TT, Uusitupa M, Tuomilehto J; Finnish Diabetes Prevention Study Group. Sustained reduction in the incidence of type 2 diabetes by lifestyle intervention: follow-up of the Finnish Diabetes Prevention Study. Lancet. 2006 Nov 11;368(9548):1673-9. doi: 10.1016/S0140-6736(06)69701-8. | |
| 21235825 |
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| ID | Term |
|---|---|
| D003920 | Diabetes Mellitus |
| D002318 | Cardiovascular Diseases |
| D018149 | Glucose Intolerance |
| D011236 | Prediabetic State |
| D009369 | Neoplasms |
| ID | Term |
|---|---|
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
| D004700 | Endocrine System Diseases |
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| Through study completion, an average of about 1.5 years |
| Height | The subject's height was recorded, and the results were recorded in centimeters. | Through study completion, an average of about 1.5 years |
| Exercise frequency and intensity | The subjects' daily exercise frequency and intensity were recorded. | Through study completion, an average of about 1.5 years |
| Coronary heart disease incidence | This study statistically analyzed the incidence of coronary heart disease at the end of the study through interview, medical record review, physical examination | Through study completion, an average of about 1.5 years |
| all-cause deaths | This study counted all-cause deaths at the end of the study through death certificate, medical record review, family interview | Through study completion, an average of about 1.5 years |
| incidence of diabetic peripheral neuropathy | This study statistically analyzed the incidence of diabetic peripheral neuropathy at the end of the study through interview, medical record review, physical examination | Through study completion, an average of about 1.5 years |
| other cause mortality | This study statistically analyzed other cause mortality at the end of the study through death record, medical record review, family interview | Through study completion, an average of about 1.5 years |
| cardiovascular mortality rate | This study statistically analyzed the cardiovascular mortality rate at the end of the study through death certificate, medical record review, family interview | Through study completion, an average of about 1.5 years |
| incidence of blindness | This study statistically analyzed the incidence of blindness at the end of the study through interview, medical record review, physical examination | Through study completion, an average of about 1.5 years |
| Diabetic retinopathy incidence | This study statistically analyzed the incidence of diabetic retinopathy at the end of the study through interview, medical record review, physical examination | Through study completion, an average of about 1.5 years |
| Diabetic nephropathy incidence | This study statistically analyzed the incidence of diabetic nephropathy at the end of the study through interview, medical record review, physical examination | Through study completion, an average of about 1.5 years |
| Peripheral vascular disease incidence | This study statistically analyzed the incidence of peripheral vascular disease at the end of the study through interview, medical record review, physical examination | Through study completion, an average of about 1.5 years |
| Heart failure incidence | This study statistically analyzed the incidence of heart failure at the end of the study through interview, medical record review, physical examination | Through study completion, an average of about 1.5 years |
| Stroke incidence | This study statistically analyzed the incidence of stroke at the end of the study through interview, medical record review, physical examination | Through study completion, an average of about 1.5 years |
| dietary habits | The subjects' eating habits and dietary preferences were assessed through patient interviews. | Through study completion, an average of about 1.5 years |
| health-related quality of life | The EuroQol questionnaire or health status questionnaire was administered through patient interviews to assess the subjects' health-related quality of life. | Through study completion, an average of about 1.5 years |
| blood pressure | During the visit, the subjects' systolic and diastolic blood pressures were measured at rest by physical examination. The measurements were performed twice and the average was taken. | Through study completion, an average of about 1.5 years |
| blood sugar | Blood samples were collected from the subjects at 1 hour and 2 hours after the steamed bread meal when they were fasting. The blood samples were used to test blood sugar levels and blood lipids, including total cholesterol, triglycerides, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol. | Through study completion, an average of about 1.5 years |
| blood lipid | Venous blood was collected from the subjects in a fasting state. The blood samples were used to test blood lipid status, including total cholesterol, triglycerides, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol. | Through study completion, an average of about 1.5 years |
| skin AGE | The skin AGE of the subjects was measured by physical examination. After cleaning the inner skin of the forearm, the AGE Reader probe was gently placed on the skin surface, the excitation light was emitted and the fluorescence intensity was recorded. The results were repeated 3 times and the average value was taken. | Through study completion, an average of about 1.5 years |
| Tidal Volume | The subjects were assessed for Tidal Volume, which reflects the ventilation efficiency in the basic breathing state. Tidal Volume is measured in liters. | Through study completion, an average of about 1.5 years |
| Functional Residual Capacity | Subjects were assessed for Functional Residual Capacity, which reflects lung capacity. Functional Residual Capacity is measured in liters. | Through study completion, an average of about 1.5 years |
| Forced Vital Capacity | The subjects were assessed for Forced Vital Capacity, which reflects the overall ventilation capacity of the lungs. Forced Vital Capacity is measured in liters. | Through study completion, an average of about 1.5 years |
| Forced Expiratory Volume in 1 second | The subjects were assessed for Forced Expiratory Volume in 1 second, which reflects respiratory reserve capacity. Forced Expiratory Volume in 1 second is measured in liters. | Through study completion, an average of about 1.5 years |
| Background |
| Sakane N, Sato J, Tsushita K, Tsujii S, Kotani K, Tsuzaki K, Tominaga M, Kawazu S, Sato Y, Usui T, Kamae I, Yoshida T, Kiyohara Y, Sato S, Kuzuya H; Japan Diabetes Prevention Program (JDPP) Research Group. Prevention of type 2 diabetes in a primary healthcare setting: three-year results of lifestyle intervention in Japanese subjects with impaired glucose tolerance. BMC Public Health. 2011 Jan 17;11(1):40. doi: 10.1186/1471-2458-11-40. |
| 11333990 | Background | Tuomilehto J, Lindstrom J, Eriksson JG, Valle TT, Hamalainen H, Ilanne-Parikka P, Keinanen-Kiukaanniemi S, Laakso M, Louheranta A, Rastas M, Salminen V, Uusitupa M; Finnish Diabetes Prevention Study Group. Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance. N Engl J Med. 2001 May 3;344(18):1343-50. doi: 10.1056/NEJM200105033441801. |
| 16391903 | Background | Ramachandran A, Snehalatha C, Mary S, Mukesh B, Bhaskar AD, Vijay V; Indian Diabetes Prevention Programme (IDPP). The Indian Diabetes Prevention Programme shows that lifestyle modification and metformin prevent type 2 diabetes in Asian Indian subjects with impaired glucose tolerance (IDPP-1). Diabetologia. 2006 Feb;49(2):289-97. doi: 10.1007/s00125-005-0097-z. Epub 2006 Jan 4. |
| 9096977 | Background | Pan XR, Li GW, Hu YH, Wang JX, Yang WY, An ZX, Hu ZX, Lin J, Xiao JZ, Cao HB, Liu PA, Jiang XG, Jiang YY, Wang JP, Zheng H, Zhang H, Bennett PH, Howard BV. Effects of diet and exercise in preventing NIDDM in people with impaired glucose tolerance. The Da Qing IGT and Diabetes Study. Diabetes Care. 1997 Apr;20(4):537-44. doi: 10.2337/diacare.20.4.537. |
| 11832527 | Background | Knowler WC, Barrett-Connor E, Fowler SE, Hamman RF, Lachin JM, Walker EA, Nathan DM; Diabetes Prevention Program Research Group. Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. N Engl J Med. 2002 Feb 7;346(6):393-403. doi: 10.1056/NEJMoa012512. |
| 31036503 | Background | Gong Q, Zhang P, Wang J, Ma J, An Y, Chen Y, Zhang B, Feng X, Li H, Chen X, Cheng YJ, Gregg EW, Hu Y, Bennett PH, Li G; Da Qing Diabetes Prevention Study Group. Morbidity and mortality after lifestyle intervention for people with impaired glucose tolerance: 30-year results of the Da Qing Diabetes Prevention Outcome Study. Lancet Diabetes Endocrinol. 2019 Jun;7(6):452-461. doi: 10.1016/S2213-8587(19)30093-2. Epub 2019 Apr 26. |
| 34212465 | Background | Gong Q, Zhang P, Wang J, Gregg EW, Cheng YJ, Li G, Bennett PH; Da Qing Diabetes Prevention Outcome Study Group. Efficacy of lifestyle intervention in adults with impaired glucose tolerance with and without impaired fasting plasma glucose: A post hoc analysis of Da Qing Diabetes Prevention Outcome Study. Diabetes Obes Metab. 2021 Oct;23(10):2385-2394. doi: 10.1111/dom.14481. Epub 2021 Jul 27. |
| D006943 | Hyperglycemia |