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| Name | Class |
|---|---|
| International Centre for Diarrhoeal Disease Research, Bangladesh | OTHER |
| North South University | OTHER |
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The goal of the experimental study is to understand the impact of heat stress on core temperature and telomere length. Investigators will recruit rickshaw drivers who use manual power to push their rickshaws and randomly assign half of them to receive battery-powered rickshaws to use for four months. Investigators will assess how this change impacts their core body temperature while they work, the length of their telomeres (caps on the end of DNA that are associated with aging), and kidney function.
Personal exposure to heat may be elevated above ambient temperatures if an individual is very active (which generates metabolic heat) or wears clothing that prevents cooling. Age can influence the consequences of heat stress. Older adults are at elevated risk of adverse impacts from heat stress due to their reduced ability to dissipate heat. Heat stress is particularly high among outdoor workers. South Asia has millions of bicycle rickshaw drivers, who use their muscles or battery power to pull hundreds of pounds of passengers and goods on modified bicycles. When manual rickshaw drivers rest to cool off, they reduce their already meager income. Heat stress not only threatens their livelihoods and thereby their right to an adequate standard of living but also their right to work, given that they have few employable skills other than manual labor. South Asia faces the greatest current and predicted loss in disability-adjusted life years due to heat stress, and heat stress is particularly strong in informal settlements. As such, the investigators plan to conduct this study in Dhaka, Bangladesh. The overall hypothesis is that driving a battery-powered rickshaw will reduce heat strain. The investigators will evaluate the impact of driving a battery-powered rickshaw on core temperature (primary outcome), telomere length, kidney function, heart rate, heart rate variability, sleep quality, self-reported thermal comfort, mental health, wellness, and fatigue (secondary outcomes).
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Manual rickshaw | No Intervention | Rickshaw drivers will use manually powered rickshaws | |
| Battery-powered rickshaw | Experimental | Rickshaw drivers will use battery-powered rickshaws |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Battery-powered rickshaw | Device | A battery-powered rickshaw is a rickshaw where the wheels are turned by a small electric motors powered by a battery. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Core temperature | Minutes per day that core temperature is >40C, where fewer minutes per day is better | 0 (pre-intervention) and 2, 4, 6, 8, 10, 12, 14, 16 weeks post-intervention |
| Measure | Description | Time Frame |
|---|---|---|
| Relative Leucocyte Telomere Length | Change in Relative Leucocyte Telomere Length measured by PCR, where a smaller reduction in length is better | 0 (pre-intervention) and 16 weeks post-intervention |
| Kidney function |
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Inclusion Criteria:
Exclusion Criteria:
Self-identify as a male. We will use this information about gender only as a proxy for sex, as we will not be assessing sex through chromosomal analysis.
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Laura Kwong, PhD | Contact | 16504609593 | lakwong@berkeley.edu |
| Name | Affiliation | Role |
|---|---|---|
| Laura Kwong, PhD | University of California, Berkeley | Principal Investigator |
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We will post de-identified participant data on our OSF repository (https://osf.io/sd285/)
We expect that data and code will become available by 1 Jan 2027
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| ID | Term |
|---|---|
| D018882 | Heat Stress Disorders |
| D007319 | Sleep Initiation and Maintenance Disorders |
| ID | Term |
|---|---|
| D014947 | Wounds and Injuries |
| D020919 | Sleep Disorders, Intrinsic |
| D020920 | Dyssomnias |
| D012893 | Sleep Wake Disorders |
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Stepped-wedge randomized controlled trial
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kidney function, as measured by a the neutrophil gelatinase-associated lipocalin (NGAL) value in urine samples, where a lower score is better
| 0 (pre-intervention) and 2, 4, 6, 8, 10, 12, 14, 16 weeks post-intervention |
| Heart rate | resting heart rate (bpm), where a lower heart rate is better | 0 (pre-intervention) and 2, 4, 6, 8, 10, 12, 14, 16 weeks post-intervention |
| Heart rate variability | resting heart rate (bpm) variability, where higher variability is better | 0 (pre-intervention) and 2, 4, 6, 8, 10, 12, 14, 16 weeks post-intervention |
| Sleep quality | Self-reported sleep quality and number of minutes in REM, as recorded by a fitness watch, where more minutes in REM is better | 0 (pre-intervention) and 2, 4, 6, 8, 10, 12, 14, 16 weeks post-intervention |
| D009422 |
| Nervous System Diseases |
| D001523 | Mental Disorders |