Children undergoing leukaemia treatment are exposed to a wide range of chemotherapeutic agents and immunosuppressive therapies during treatment and are therefore at great risk for complications. Mucositis is one of the leading chemotherapy-related complications affecting the quality of life of the child. Although it varies according to the degree of mucositis, oral mucosal erythema, white plaques and ulcers are extremely painful and traumatising procedures for pediatric patients during mucositis care. The pain and fear they experience during the procedure may lead children to delay/not perform oral mucositis care or not allow their parents to do so. Since mucositis is a painful condition in children, it is recommended to use distracting nonpharmacological methods that can help reduce the pain and fear of children during mucositis care. In this context, the aim of this study was to determine the effects of music and virtual reality on pain, anxiety and fear during oral mucositis care in children aged 6-12 years receiving leukaemia treatment. Block randomisation (gender (F/M) and age groups (6-9/10-12) will be used to identify participants. Five minutes before the oral mucositis care procedure, all participants, regardless of group, will be assessed with the Child Anxiety Scale-Disposition (CAS-D), Child Fear Scale and Visual Analogue Scale (VAS). The study will be conducted in three groups as control group, VR group and music group. Descriptive characteristics of dependent and independent categorical variables will be given as number and percentage, numerical descriptive characteristics will be given as mean and standard deviation. In examining the relationship between dependent and independent variables, Mann Whitney-Kruskal Wallis or Student t-Anova analyses will be performed according to the result of the analysis of conformity to normal distribution. Bonferroni analysis will be used for pairwise comparisons and Covariance analysis will be used to investigate the effect of variables with children.

Inclusion Criteria:

The participant child

• is between the ages of 6-12 years
• is being followed up as an inpatient in the Paediatric Haematology Clinic
• is receiving leukaemia treatment only
• has oral mucositis
• does not have a systemic infection
• willing to participate in the study
• speak Turkish and are open to communication
• has no visual and hearing problems (not using glasses or hearing aids)

Exclusion Criteria:

• Cases not fulfilling the inclusion criteria will be excluded from the study.

Since leukaemia is more common in boys, biological sex will be taken as the basis for this study.

Patient data will not be shared for ethical reasons.

Oral mucositis care will be provided by the same clinic nurse in all groups in the study and this care provider will not be blinded to the intervention. The nurse will be accompanied by a researcher at this time. This person is the person who will collect the data for the scales and will not be blinded in the study. However, the person who will do the analyses of the study tests will be blinded to the groups.