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This study aims to evaluate how retroperitoneal lymph node dissection (RPLND), a surgical treatment for testicular cancer, may affect urinary and sexual functions in men. RPLND involves the removal of lymph nodes from the abdominal area and is sometimes necessary in patients who are not eligible for chemotherapy or who have residual disease after chemotherapy. While this surgery is known to carry a risk of affecting ejaculation, its potential impact on other areas such as urination or erection is not well understood.
The study will prospectively follow adult men undergoing RPLND. It will assess changes in lower urinary tract symptoms, urine flow, ejaculation, erection, and overall quality of life before surgery and during follow-up visits up to 6 months after the operation. Patients will complete standardized questionnaires and undergo simple, non-invasive tests such as urine flow measurement.
By identifying how RPLND may influence urinary and sexual health, this study seeks to improve understanding of the full range of effects of this treatment. The findings may help clinicians better inform patients before surgery and support improved post-operative care.
This is a prospective observational study designed to evaluate the impact of retroperitoneal lymph node dissection (RPLND) on lower urinary tract and sexual function in patients treated for testicular cancer. The study incorporates validated patient-reported outcome measures (PROMs) alongside objective functional assessments to characterize post-RPLND urinary and sexual sequelae over time.
Patients will complete standardized questionnaires preoperatively and at scheduled postoperative intervals, including the International Prostate Symptom Score (IPSS), International Consultation on Incontinence Questionnaire - Male Lower Urinary Tract Symptoms (ICIQ-MLUTS), International Index of Erectile Function (IIEF-5), Male Sexual Health Questionnaire - Ejaculatory Dysfunction (MSHQ-EjD), and EQ-5D-5L for health-related quality of life. Objective evaluation will include uroflowmetry and ultrasound-based measurement of post-void residual volume.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Adult men with testicular cancer undergoing retroperitoneal lymph node dissection | Adult men with testicular cancer undergoing retroperitoneal lymph node dissection will have uroflowmetry performed and will complete questionnaires focusing on urinary, erectile and ejaculatory function before surgery, after surgery and during 6 months follow-up |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Uroflowmetry and questionnaires | Diagnostic Test | Uroflowmetry - urine flow assessment Questionnaires: IPSS, ICIQ-MLUTS, IIEF-5, MSHQ-EjD, EQ-5D-5L |
|
| Measure | Description | Time Frame |
|---|---|---|
| Change in maximal urine flow (Qmax) in uroflowmetry before and after RPLND surgery | Change in maximal urine flow (Qmax) in uroflowmetry before and after RPLND surgery | 6 months |
| Change in post-void residual volume (PVR) before and after RPLND surgery | Change in post-void residual volume (PVR) before and after RPLND surgery | 6 months |
| Change in total IPSS score before and after RPLND surgery | Patients will complete International Prostate Symptom Score (IPSS) questionnaire to assess urinary function before and after surgery | 6 months |
| Change in ICIQ-MLUTS score before and after RPLND surgery | Patients will complete Incontinence Questionnaire - Male Lower Urinary Tract Symptoms - ICIQ-MLUTS questionnaire to assess urinary function before and after surgery | 6 months |
| Measure | Description | Time Frame |
|---|---|---|
| Change in IIEF-5 questionnaire before and after RPLND surgery | Patients will complete International Index of Erectile Function - IIEF-5 questionnaire before and after surgery to assess erectile function | 6 months |
| Change in MSHQ-EjD questionnaire before and after RPLND surgery |
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Inclusion Criteria:
Exclusion Criteria:
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Adult males with testicular cancer undergoing retroperitoneal lymph node dissection (RPLND)
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Anna K. Czech, M.D., Ph.D. | Contact | +48124002500 | aka.czech@uj.edu.pl | |
| Jakub Frydrych, M.D. | Contact | +48124002500 | frydrych.jf@gmail.com |
| Name | Affiliation | Role |
|---|---|---|
| Anna K. Czech, M.D. | Jagiellonian University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Jagiellonian University Medical College | Recruiting | Krakow | Malopolska | 30-688 | Poland |
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| ID | Term |
|---|---|
| D013736 | Testicular Neoplasms |
| ID | Term |
|---|---|
| D004701 | Endocrine Gland Neoplasms |
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
| D005834 | Genital Neoplasms, Male |
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Patients will complete Male Sexual Health Questionnaire Ejaculatory Dysfunction - MSHQ-EjD questionnaire before and after surgery to assess erectile function |
| 6 months |
| D014565 |
| Urogenital Neoplasms |
| D005832 | Genital Diseases, Male |
| D000091662 | Genital Diseases |
| D000091642 | Urogenital Diseases |
| D052801 | Male Urogenital Diseases |
| D004700 | Endocrine System Diseases |
| D013733 | Testicular Diseases |
| D006058 | Gonadal Disorders |