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To establish a headache center in China that combines clinical, imaging and laboratory examinations, explore the feasible treatment options for migraine combined with patent foramen ovale, and search for the possible influencing factors, construct models that influence prognosis.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Conservative group | Don't use antiplatelet drugs or undergo patent foramen ovale closure. |
| |
| Antiplatelet group | The application of antiplatelet drug. |
| |
| PFO group | Receive a patent foramen ovale closure surgery. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Conservative treatment | Drug | Receive no antipaletet drug treatment and surgery |
| |
| Measure | Description | Time Frame |
|---|---|---|
| The changes of migraine attacks | Migraine attacks are an important indicator of improvement in symptoms. The comparison measures included headache frequency, duration, pain degree, VAS scores, HIT-6 scores, HAMA, HAMD, and PSQI. | 3 months, 6 months, 1 year, 2 years and 3 years |
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Inclusion Criteria:
Exclusion Criteria:
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All clinically confirmed migraine patients with PFO who met the inclusion criteria were included.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Yu Fu | Contact | 13671185050 | lilac_fu@126.com |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Peking University Third Hospital | Recruiting | Beijing | China |
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| ID | Term |
|---|---|
| D008881 | Migraine Disorders |
| D054092 | Foramen Ovale, Patent |
| ID | Term |
|---|---|
| D051270 | Headache Disorders, Primary |
| D020773 | Headache Disorders |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
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| ID | Term |
|---|---|
| D000072700 | Conservative Treatment |
| ID | Term |
|---|---|
| D013812 | Therapeutics |
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| Antipaletet drug |
| Drug |
Use of antipaletet drugs. |
|
| Patent Foramen Ovale Closure | Procedure | Receive the surgery of Patent Foramen Ovale |
|
| D009422 | Nervous System Diseases |
| D006344 | Heart Septal Defects, Atrial |
| D006343 | Heart Septal Defects |
| D006330 | Heart Defects, Congenital |
| D018376 | Cardiovascular Abnormalities |
| D002318 | Cardiovascular Diseases |
| D006331 | Heart Diseases |
| D000013 | Congenital Abnormalities |
| D009358 | Congenital, Hereditary, and Neonatal Diseases and Abnormalities |