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This open-label pilot study includes adults aged 45 to 79 residing in the United States. The study will last 7 days. Participants will provide blood samples via an at-home finger-prick kit at baseline and day 7 and complete electronic surveys on health indicators at baseline, and days 3 and 7. All procedures are conducted remotely, with no in-person visits, to collect real-world evidence.
Objectives Within-group changes in outcomes will be compared from baseline to the end of the study period.
Primary Outcome Measures:
Biomarkers in blood, measured using the Olink Target 48 Cytokine panel:
Tumor Necrosis Factor (TNF) Interleukin-1 Beta (IL1B) Interleukin-8 (CXCL8) Vascular Endothelial Growth Factor A (VEGFA)
Secondary Outcome Measures:
Remaining biomarkers in the Olink Target 48 Cytokine panel 36-Item Short Form Health Survey (SF-36) Frailty Index for Elders (FIFE) Depression Anxiety Stress Scale-21 (DASS-21)
Side effect profile including:
Number, type, severity, causality, and outcome of adverse events or unanticipated problems
Symptoms of aging, assessed by:
Aging Male Symptom scale Aging Female Symptom scale
Participant Details:
Study Duration per Participant: 7 days Total Number of Participants: 40
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Qualia Senolytic | Active Comparator |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Qualia Senolytic | Dietary Supplement | Qualia Senolytic manufactured by Qualia Life Science |
|
| Measure | Description | Time Frame |
|---|---|---|
| Olink Target 48 Cytokine panel - TNF, IL1B, CXCL8, VEGFA | Biomarkers in blood, measured using the Olink Target 48 Cytokine panel: Tumor Necrosis Factor (TNF) Interleukin-1 Beta (IL1B) Interleukin-8 (CXCL8) Vascular Endothelial Growth Factor A (VEGFA) | 1 week |
| Measure | Description | Time Frame |
|---|---|---|
| Remaining biomarkers in the Olink Target 48 Cytokine panel | 1 week | |
| 36-Item Short Form Health Survey (SF-36) | 1 week | |
| Frailty Index for Elders (FIFE) |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| William Scuba | Contact | 855-281-2328 | support@qualialife.com |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Qualia Life Sciences | Carlsbad | California | 92011 | United States |
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| ID | Term |
|---|---|
| D007249 | Inflammation |
| ID | Term |
|---|---|
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
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| 1 week |
| Depression Anxiety Stress Scale-21 (DASS-21) | 1 week |
| Aging Male/Female Symptom scale | 1 week |
| Side effect profile as measured by a custom Safety and Tolerability survey | Number of participants with treatment-related adverse events as assessed by a score of 3 or greater on the Safety and Tolerability survey | 1 week |