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| Name | Class |
|---|---|
| Ruijin Hospital | OTHER |
| Nanjing Medical University | OTHER |
| Second Affiliated Hospital of Soochow University | OTHER |
| Beijing Hospital |
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A quantitative evaluation method was developed for Parkinson's disease and other atypical parkinonism by integrating an innovative motor paradigm with perception technologies and artificial intelligence. Combined with traditional motor paradigms and the acute levodopa challenge test, this study aims to identify diagnostic cut-off values for PD and other atypical parkinonism, explore digital biomarkers for early and differential diagnosis, and establish a corresponding diagnostic model.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Parkinson's disease (PD) group: | Patients with confirmed Parkinson's disease diagnosed based on the 2015 International Movement Disorder Society (MDS) Parkinson's Disease Diagnostic Criteria. |
| |
| Multiple system atrophy (MSA) group | Patients with confirmed or probable MSA diagnosed based on the diagnostic criteria for MSA published by the International Movement Disorder Society (MDS) in 2022. |
| |
| Progressive supranuclear palsy (PSP) group | Patients with confirmed or probable PSP diagnosed based on the diagnostic criteria of the 2017 International Movement Disorder Association PSP Collaborative Group. |
| |
| Vascular parkinsonism (VP) group | In line with the diagnostic recommendations of vascular parkinsonism in accordance with the 2004 International Association for Movement Disorders and the 2017 Chinese expert consensus. |
| |
| Drug-induced parkinsonism (DIP) group | Parkinsonism. |
| |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| video recording | Other | The patient's motor symptoms were recorded via video for assessment purposes. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Accuracy | Using quantitative assessment methods, conduct exploratory research on new methods for early diagnosis.The test correctly identified the total proportion of individuals with and without the disease. | baseline |
| Diagnostic Odds Ratio | Using quantitative assessment methods, conduct exploratory research on new methods for early diagnosis.The ratio of positive likelihood ratio to negative likelihood ratio reflects the diagnostic efficiency of the test. | baseline |
| Specificity | Using quantitative assessment methods, conduct exploratory research on new methods for early diagnosis.The proportion of healthy people without a certain disease correctly identified by a diagnostic test. High specificity means that the test rarely misdiagnoses healthy people as disease patients (i.e., low false positive rate). | baseline |
| Negative Predictive Value | Using quantitative assessment methods, conduct exploratory research on new methods for early diagnosis.Among all individuals who tested negative, the proportion who were truly free of the disease. | baseline |
| Sensitivity | Using quantitative assessment methods, conduct exploratory research on new methods for early diagnosis.The proportion of patients with a disease correctly identified by a diagnostic test. High sensitivity means that the test rarely misses cases of disease (i.e., low false negative rate). | baseline |
| Positive Predictive Value | Using quantitative assessment methods, conduct exploratory research on new methods for early diagnosis.Of all the individuals who tested positive, the proportion who actually had the disease. |
| Measure | Description | Time Frame |
|---|---|---|
| Negative Predictive Value | Conduct differential diagnosis between Parkinson's disease and other Parkinsonian syndromes.Among all individuals who test negative, the proportion who are truly free of the disease. | baseline |
| root mean square error |
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Inclusion Criteria:
Exclusion Criteria:
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In this study, participants are recruited from the multicenters across China. Participants are enrolled through outpatient assessment and screening.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Tao Feng, MD | Contact | 86-13911125339 | bxbkyjs@sina.com | |
| Lingyan Ma, MD | Contact | 86-13520873987 | Jennifer_MLY@163.com |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Beijing Tiantan Hospital, Affiliated to Capital Medical University | Recruiting | Beijing | 100070 | China |
Individual participant data will not be publicly available, but can be shared with collaborators under specific agreements.
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| ID | Term |
|---|---|
| D000088282 | Corticobasal Degeneration |
| D010300 | Parkinson Disease |
| D013494 | Supranuclear Palsy, Progressive |
| D019578 | Multiple System Atrophy |
| ID | Term |
|---|---|
| D024801 | Tauopathies |
| D019636 | Neurodegenerative Diseases |
| D009422 | Nervous System Diseases |
| D020734 | Parkinsonian Disorders |
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| ID | Term |
|---|---|
| D014743 | Videotape Recording |
| ID | Term |
|---|---|
| D013637 | Tape Recording |
| D001296 | Audiovisual Aids |
| D018961 | Educational Technology |
| D013672 | Technology |
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| OTHER_GOV |
| Fujian Medical University Union Hospital | OTHER |
| Guangdong Provincial People's Hospital | OTHER |
| West China Hospital | OTHER |
| The First Affiliated Hospital of Dalian Medical University | OTHER |
| China-Japan Union Hospital, Jilin University | OTHER |
| Renmin Hospital of Wuhan University | OTHER |
| First Affiliated Hospital of Chongqing Medical University | OTHER |
| Second Affiliated Hospital of Nanchang University | OTHER |
| Xijing Hospital | OTHER |
| The Affiliated Hospital of Qingdao University | OTHER |
| The Second Affiliated Hospital of Xinjiang Medical University | UNKNOWN |
| Shenzhen People's Hospital | OTHER |
| Tianjin Medical University General Hospital | OTHER |
| Qilu Hospital of Shandong University | OTHER |
| The First People's Hospital of Yunnan | OTHER |
| The First Hospital of Jilin University | OTHER |
| Tianjin Huanhu Hospital | OTHER |
| The First Affiliated Hospital of Anhui Medical University | OTHER |
| Wannan Medical College Yijishan Hospital | OTHER |
| The Affiliated Hospital of Xuzhou Medical University | OTHER |
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| Corticobasal degeneration (CBD) group |
Diagnosis of probable or probable CBD based on the 2019 Chinese diagnostic criteria for corticobasal degeneration. |
|
| Dementia with Lewy Bodies (DLB) Group | Diagnosed as probable or possible DLB based on the 2017 international DLB diagnostic criteria and the 2021 Chinese DLB diagnostic criteria. |
|
| baseline |
Quantify the magnitude of the prediction error
| baseline |
| Correlation Coefficient | Strength of the linear relationship between reflection and true results | baseline |
| Specificity | Conduct differential diagnosis between Parkinson's disease and other Parkinsonian syndromes.Diagnostic tests correctly identify the proportion of healthy people who do not have a disease. | baseline |
| Sensitivity | Conduct differential diagnosis between Parkinson's disease and other Parkinsonian syndromes.Refers to the proportion of patients with a disease that a diagnostic test correctly identifies. | baseline |
| Positive Predictive Value | Conduct differential diagnosis between Parkinson's disease and other Parkinsonian syndromes.Of all the individuals who tested positive, the proportion who actually had the disease | baseline |
| Coefficient of Determination | The proportion of variation that reflects the interpretation of the results | baseline |
| Diagnostic Odds Ratio | Conduct differential diagnosis between Parkinson's disease and other Parkinsonian syndromes.The ratio of positive likelihood ratio to negative likelihood ratio reflects the diagnostic efficiency of the test. | baseline |
| Accuracy | Conduct differential diagnosis between Parkinson's disease and other Parkinsonian syndromes.The total proportion of individuals with and without the disease correctly identified by the test | baseline |
| Intraclass Correlation Coefficient | Conduct differential diagnosis between Parkinson's disease and other Parkinsonian syndromes.Consistency and reliability of evaluation results | baseline |
| D001480 |
| Basal Ganglia Diseases |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009069 | Movement Disorders |
| D000080874 | Synucleinopathies |
| D009886 | Ophthalmoplegia |
| D015835 | Ocular Motility Disorders |
| D003389 | Cranial Nerve Diseases |
| D010243 | Paralysis |
| D009461 | Neurologic Manifestations |
| D005128 | Eye Diseases |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D054969 | Primary Dysautonomias |
| D001342 | Autonomic Nervous System Diseases |
| D013676 |
| Technology, Industry, and Agriculture |
| D013690 | Television |