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This measurement aims to understand the effect of self-acupressure on the Shenmen Point (神門) and (內關) points on the hand on emotional distress, anxiety, depression, stress, work fatigue and adaptability of clinical nurses. The main questions it aims to answer are:
Whether acupressure can reduce emotional distress, anxiety, depression, stress and work fatigue in nursing staff.
Participants will:
1. Enforcement measures:
Purpose of the Study:
The goal of this study is to understand emotional distress, anxiety, depression, stress, workplace fatigue, and resilience among clinical nurses, as well as the factors related to these conditions. Investigators also want to evaluate the effects of different coping methods-either by self-pressing specific acupuncture points (Shenmen and Neiguan on the hand) or using usual ways of managing stress and anxiety.
About the Acupressure Points:
• Shenmen Point (神門): Shenmen, located on the inner wrist, is a key point on the Heart Meridian. It's often used in traditional Chinese medicine to calm the mind, ease anxiety, help with sleep problems, headaches, and emotional fatigue.
• Neiguan Point (內關): Neiguan is located on the inner forearm. Pressing this point can help relieve stress, reduce bloating, calm palpitations, and improve sleep. It's often used when feeling tense or anxious.
• Usual Coping Methods: If participants are assigned to this group, participants will simply continue handling stress and anxiety the way you normally do.
Who Can Join the Study:
Participants can join this study if:
Participants cannot join this study if:
Study Procedures:
If participants agree to participate and sign the consent form, researchers will ask participants to fill out several questionnaires. These will cover basic info, emotional distress, mood, depression, anxiety, work stress, fatigue, and resilience. It takes about 10-20 minutes to complete.
If participants distress score is 3 or higher, or your mood score is 4 or higher, participants will be randomly assigned to one of two groups:
• Acupressure Group: Participants will learn how to press the Shenmen and Neiguan acupoints on their hands and press them twice a day (about 2 minutes each time) for 2 weeks. participants will also keep a simple daily log of your acupressure practice.
• Usual Care Group: Participants will continue with usual ways of coping and fill out a short daily emotional self-assessment form.
Investigators will check in with participants every week using the same set of questionnaires to track changes for two months. In total, participants will be asked to fill out the survey 9 times.
Possible Side Effects and How to Handle Them:
• From the Acupressure: When pressing the Shenmen or Neiguan points, participants might feel a sensation like soreness, tingling, pressure, or slight pain-this is normal and usually tolerable. There's no research showing any harmful side effects from pressing these points. If it ever feels too uncomfortable, participants can adjust the pressure.
• From Participation: The risks of participating in this study were similar to participants' normal, everyday experiences. Participants were free to stop at any time if they felt sick or uncomfortable during the study. Participants can also contact the program's emergency contacts.
Expected Benefits:
Past research and traditional practice have shown that pressing the Shenmen and Neiguan points can help reduce anxiety, stress, insomnia, and related symptoms. While the researchers cannot guarantee that this study will help individual participants, it may help healthcare professionals understand ways to better support caregivers and could benefit others in the future.
The researcher's requirements for participants during the study:
Participants' privacy is protected:
Researchers will only collect information necessary for this study. All personal data and survey responses of participants will remain confidential. The researcher will not use the participant's name or personal identification, but will assign a code to the participant so that the participant's identity remains anonymous in all records.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Control group | No Intervention | Care continued in the original manner without any intervention. | |
| Intervention group (Acupressure) | Experimental | Participants perform self-acupressure on the Shenmen and Neiguan points twice daily for 2 weeks. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Acupressure | Behavioral | Participants in this group will receive instruction on how to perform self-acupressure targeting two specific acupoints on the hands: Shenmen and Neiguan. The acupressure protocol includes pressing each acupoint approximately 15 times (about 30 seconds), with a total of four acupoints per session (both hands), for approximately 2 minutes per session. Pressure should be applied until a sensation of soreness, numbness, fullness, or slight pain is felt (equivalent to about 3 kg of pressure). Participants are asked to perform self-acupressure twice daily (once in the afternoon and once before bedtime, adjustable based on personal schedule) for a total of 2 weeks. They will record their practice using a daily log and continue to complete psychological and emotional outcome questionnaires weekly over a 2-month follow-up period. |
| Measure | Description | Time Frame |
|---|---|---|
| Depressive Symptoms | Depressive symptoms were assessed using the Taiwanese Depression Scale, which has demonstrated strong psychometric properties in Taiwanese populations. The TDS consists of 18 items rated on a 4-point Likert scale: 0 = none or seldom (less than one day per week), 1 = sometimes (one to two days per week), 2 = often (three to four days per week), and 3 = almost always (five to seven days per week). Total scores range from 0 to 54, with higher scores indicating greater severity of depressive symptoms. The results from Lee et al. (2000) demonstrated that the TDS had excellent reliability and validity. The Cronbach's alpha coefficient was 0.90, and the area under the receiver operating characteristic (ROC) curve was 0.92. The TDS also showed good concurrent validity, with a sensitivity of 0.89 and specificity of 0.92 at a cutoff score of 19. In the present study, the TDS demonstrated excellent internal consistency, with a Cronbach's alpha of .94. | At baseline(weeks 0) and once weekly for 8 weeks(weeks 1-8) |
| Psychological Distress | Psychological distress was measured using the Brief Symptom Rating Scale-5 (BSRS-5), a validated screening tool for general psychological distress. The BSRS-5 assesses the subjective severity of the following symptoms: (1) anxiety, (2) depression, (3) hostility, (4) low self-esteem, and (5) insomnia. Each symptom was scored on a 5-point Likert scale, ranging from 0 ("not at all") to 4 ("extremely"), with a total score ranging from 0 to 20 points. Higher scores indicate more severe psychological distress. Studies have shown that a total score of 3-4 is the optimal threshold for identifying clinically relevant distress based on receiver operating characteristic (ROC) curve analysis. The BSRS-5 showed high accuracy (AUC = 0.92) and good sensitivity (0.83) and specificity (0.86). Therefore, this study used a BSRS-5 total score ≥4 as one of the inclusion criteria to ensure that participants with at least mild psychological distress were included in the study. | At baseline(weeks 0) and once weekly for 8 weeks(weeks 1-8) |
| Measure | Description | Time Frame |
|---|---|---|
| Resilience | This scale assesses an individual's ability to adapt and recover from stress and adversity. Each item is rated on a 5-point Likert scale, ranging from 1 ("strongly disagree") to 5 ("strongly agree"), with a total score ranging from 10 to 50, with higher scores indicating greater resilience. Initial validation studies demonstrated strong psychometric properties, including good model fit in confirmatory factor analysis (GFI = 0.973) and excellent internal consistency (Cronbach's α = .91). All instruments used in this study were authorized by their original developers and have been psychometrically validated in previous studies. All scales demonstrated good to excellent internal consistency, with Cronbach's α values ranging from 0.84 to 0.95. |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Li-Ying Lin, PhD | supervise | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Kaohsiung Veterans General Hospital | Kaohsiung City | Zuoying District | 813414 | Taiwan |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 38436194 | Background | Zhou XQ, Han YF, Xu MX. Effects of different intervention methods on psychological anxiety, stress, and fatigue among healthcare workers during COVID-19 pandemic: a systematic review and meta-analysis. Eur Rev Med Pharmacol Sci. 2024 Feb;28(4):1614-1623. doi: 10.26355/eurrev_202402_35491. | |
| 40110387 | Background |
| Label | URL |
|---|---|
| Effects and safety of auricular acupressure on depression and anxiety in isolated COVID-19 patients: A single-blind randomized controlled trial. | View source |
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Among those who met the criteria of emotional distress score ≥ 3 points (0-10 points) or emotional thermometer score ≥ 4 points, 160 subjects were selected and randomly divided into a control group or an acupoint massage group for an 8-week follow-up (the acupoint massage group was required to press the Shenmen and Neiguan acupoints on their own in the first two weeks, and the control group received no intervention measures), and filled out questionnaires every week for post-test follow-up.
Clinical nurses aged ≥20 years were pre-screened with a questionnaire, and those with an emotional distress score ≥3 (0-10 points) or an emotional thermometer score ≥4 after screening were included (this was the week 0 of enrollment).
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| ID | Title | Description |
|---|---|---|
| FG000 | Control Group | Care continued in the original manner without any intervention. |
| FG001 | Intervention Group (Acupressure) | Participants perform self-acupressure on the Shenmen and Neiguan points twice daily for 2 weeks. |
| Title | Milestones | Reasons Not Completed | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Overall Study |
|
A pretest was conducted on clinical nurses in medical centers aged ≥20 years, and 160 nurses with emotional distress ≥3 points or emotional thermometer ≥4 points were selected as intervention subjects. A randomized controlled trial was conducted, in which nurses were randomly assigned to the intervention group and the control group by computer random numbering, and an eight-week follow-up.
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| ID | Title | Description |
|---|---|---|
| BG000 | Control Group | Care continued in the original manner without any intervention. |
| BG001 | Intervention Group (Acupressure) | Participants perform self-acupressure on the Shenmen and Neiguan points twice daily for 2 weeks. |
| Units | Counts |
|---|---|
| Participants |
|
| Title | Description | Population Description | Parameter Type | Dispersion Type | Unit of Measure | Calculate Percentage | Denominator Units Selected | Denominators | Classes |
|---|---|---|---|---|---|---|---|---|---|
| Age, Continuous | The age of 160 subjects was analyzed by MEAN and Standard Deviation |
| Type | Title | Description | Population Description | Reporting Status | Anticipated Posting Date | Parameter Type | Dispersion Type | Unit of Measure | Calculate Percentage | Time Frame | Units Analyzed | Denominator Units Selected | Arm/Group Information | Denominators | Classes | Analyses |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Primary | Depressive Symptoms | Depressive symptoms were assessed using the Taiwanese Depression Scale, which has demonstrated strong psychometric properties in Taiwanese populations. The TDS consists of 18 items rated on a 4-point Likert scale: 0 = none or seldom (less than one day per week), 1 = sometimes (one to two days per week), 2 = often (three to four days per week), and 3 = almost always (five to seven days per week). Total scores range from 0 to 54, with higher scores indicating greater severity of depressive symptoms. The results from Lee et al. (2000) demonstrated that the TDS had excellent reliability and validity. The Cronbach's alpha coefficient was 0.90, and the area under the receiver operating characteristic (ROC) curve was 0.92. The TDS also showed good concurrent validity, with a sensitivity of 0.89 and specificity of 0.92 at a cutoff score of 19. In the present study, the TDS demonstrated excellent internal consistency, with a Cronbach's alpha of .94. | After the pre-test questionnaire assessment (baseline week 0), the subjects (control group/intervention group) will be followed up with a weekly questionnaire survey for eight weeks (weeks 1 to 8) after the start of the program. The depression questionnaire will obtain data for a total of nine weeks (baseline week 0 and follow-up weeks 1 to 8) and conduct data analysis. | Posted | Mean | Standard Deviation | score on a scale | At baseline(weeks 0) and once weekly for 8 weeks(weeks 1-8) |
From enrollment until end of follow-up, up to 8 weeks.
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| ID | Title | Description | Deaths (Affected) | Deaths (At Risk) | Serious Events (Affected) | Serious Events (At Risk) | Other Events (Affected) | Other Events (At Risk) |
|---|---|---|---|---|---|---|---|---|
| EG000 | Control Group | From enrollment until end of follow-up, up to 8 weeks. | 0 |
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| Title | Organization | Phone | Extension | |
|---|---|---|---|---|
| Li-Ying Lin | Kaohsiung Veterans General Hospital | 07-3422121 | 71571 | llylin@vghks.gov.tw |
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| Type | Includes Protocol | Includes SAP | Includes ICF | Document Label | Document Date | Document Uploaded Date | Document File Name |
|---|---|---|---|---|---|---|---|
| Prot_SAP | Yes | Yes | No | Study Protocol and Statistical Analysis Plan: The impact of acupressure on nurses in medical center | Dec 31, 2024 | Sep 10, 2025 | Prot_SAP_000.pdf |
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| ID | Term |
|---|---|
| D001008 | Anxiety Disorders |
| D003863 | Depression |
| D000073397 | Occupational Stress |
| D002055 | Burnout, Professional |
| ID | Term |
|---|---|
| D001523 | Mental Disorders |
| D001526 | Behavioral Symptoms |
| D001519 | Behavior |
| D009784 | Occupational Diseases |
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| ID | Term |
|---|---|
| D019050 | Acupressure |
| ID | Term |
|---|---|
| D064746 | Therapy, Soft Tissue |
| D026201 | Musculoskeletal Manipulations |
| D000529 | Complementary Therapies |
| D013812 | Therapeutics |
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This is a single-center, randomized, single-blind, parallel-controlled trial. Eligible clinical nurses will be randomly assigned (1:1) to an intervention group or a control group. The intervention group will receive self-acupressure instructions on Shenmen and Neiguan points twice a day for two weeks, and record each treatment process. The control group will continue to use their usual stress and emotional distress coping strategies without any intervention. Both groups will be required to complete a validated questionnaire covering emotional distress, mood, anxiety, depression, stress, fatigue and resilience. Assessments will be conducted weekly for two months (including pre-test (baseline week 0) and follow-up for two months (weeks 1-8), a total of 9 times) to evaluate the effectiveness of self-acupressure compared with usual care.
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| At baseline(weeks 0) and once weekly for 8 weeks(weeks 1-8) |
| Anxiety | Anxiety levels were assessed using the state subscale of the State-Trait Anxiety Inventory (STAI-S). Studies have confirmed the multidimensional factor structure of the Chinese version of the scale and demonstrated good psychometric properties, including adequate convergent and discriminant validity. In this sample, the STAI-S demonstrated excellent internal consistency (Cronbach's α = .95). The STAI-S consists of 20 items that assess anxiety-related feelings, thoughts, and behaviors at the time of assessment. Each item is rated on a 4-point Likert scale ranging from 1 ("not at all") to 4 ("very much"). Items 1, 2, 5, 8, 10, 11, 15, 16, 19, and 20 are reverse-scored. The total score ranges from 20 to 80, with scores between 20 and 39 indicating mild anxiety, 40 to 59 indicating moderate anxiety, and 60 to 80 indicating severe anxiety. | At baseline(weeks 0) and once weekly for 8 weeks(weeks 1-8) |
| Job Stress | Perceived job stress was measured using the 14-item Work Pressure Inventory developed by Huang et al. (2017), which has demonstrated good internal consistency. The scale comprises three dimensions: low self-development, workload, and job characteristics. Each item is rated on a 5-point Likert scale ranging from 1 ("strongly disagree") to 5 ("strongly agree"), with total scores ranging from 14 to 70. Higher scores indicate greater perceived occupational stress. In the original validation study, the Cronbach's α coefficients for the three subscales were 0.81, 0.73, and 0.77, respectively. In the present study, the Work Pressure Inventory showed good overall internal consistency (Cronbach's α = .84). | At baseline(weeks 0) and once weekly for 8 weeks(weeks 1-8) |
| Occupational Burnout | Occupational burnout was assessed using the Chinese version of the Copenhagen Burnout Inventory (CBI), which has demonstrated good psychometric properties in Taiwanese populations. The scale consists of four subscales: personal burnout, work-related burnout, client-related burnout, and overcommitment to work. Each item is rated on a five-point frequency scale: "always" (100), "often" (75), "sometimes" (50), "rarely" (25), and "never" (0). Subscale scores are calculated as the average of the items within each domain, ranging from 0 to 100, with higher scores indicating more severe occupational burnout. The original validation study reported Cronbach's α values above 0.84 across all subscales. In the present study, the scale demonstrated excellent internal consistency (Cronbach's α = .95). | At baseline(weeks 0) and once weekly for 8 weeks(weeks 1-8) |
| Emotional Distress | Emotional distress was measured using the Distress Thermometer (DT), a single self-report screening instrument with a score range of 0 (no distress) to 10 (extreme distress), with higher scores indicating greater emotional distress. The DT demonstrated good psychometric properties in validation studies, with sensitivities ranging from 0.50 to 1.00 (median = 0.83) and specificities ranging from 0.36 to 0.98 (median = 0.68). This study used a DT cutoff score of ≥3 as the inclusion criterion. Other studies have shown that the optimal DT cutoff score varies across settings, typically ranging from 3 to 5, while thresholds of ≥4 or ≥5 are commonly used in clinical practice. The use of a score of ≥3 in this study was intended to maximize sensitivity and minimize the risk of underidentifying caregivers considered at high risk for psychological distress. | At baseline(weeks 0) and once weekly for 8 weeks(weeks 1-8) |
| Yang X, Liu Q, Wu X. Meta-Analysis of the Clinical Efficacy of Auricular Acupressure on Patients with Depression. Alpha Psychiatry. 2025 Feb 28;26(1):38776. doi: 10.31083/AP38776. eCollection 2025 Feb. |
| 39648209 | Background | Wu X, Tu M, Yu Z, Cao Z, Qu S, Chen N, Jin J, Xiong S, Yang J, Pei S, Xu M, Wang J, Shi Y, Gao L, Xie J, Li X, Fang J, Shao X. The efficacy and cerebral mechanism of intradermal acupuncture for major depressive disorder: a multicenter randomized controlled trial. Neuropsychopharmacology. 2025 Jun;50(7):1075-1083. doi: 10.1038/s41386-024-02036-5. Epub 2024 Dec 8. |
| 38576710 | Background | Peng Z, Zheng Y, Yang Z, Zhang H, Li Z, Xu M, Cui S, Lin R. Acupressure: a possible therapeutic strategy for anxiety related to COVID-19: a meta-analysis of randomized controlled trials. Front Med (Lausanne). 2024 Mar 21;11:1341072. doi: 10.3389/fmed.2024.1341072. eCollection 2024. |
| 40004676 | Background | Pachi A, Sikaras C, Melas D, Alikanioti S, Soultanis N, Ivanidou M, Ilias I, Tselebis A. Stress, Anxiety and Depressive Symptoms, Burnout and Insomnia Among Greek Nurses One Year After the End of the Pandemic: A Moderated Chain Mediation Model. J Clin Med. 2025 Feb 10;14(4):1145. doi: 10.3390/jcm14041145. |
| 38171225 | Background | Li J, Zhang K, Zhao T, Huang W, Hou R, Wang S, Zhao M, Guo Y. Acupressure for depression: A systematic review and meta-analysis. Asian J Psychiatr. 2024 Feb;92:103884. doi: 10.1016/j.ajp.2023.103884. Epub 2023 Dec 23. |
| 38173848 | Background | Hong WK, Kim YJ, Lee YR, Jeong HI, Kim KH, Ko SG. Effectiveness of electroacupuncture on anxiety: a systematic review and meta-analysis of randomized controlled trials. Front Psychol. 2023 Dec 19;14:1196177. doi: 10.3389/fpsyg.2023.1196177. eCollection 2023. |
| 8400749 | Background | Elliott D. Comparison of three instruments for measuring patient anxiety in a coronary care unit. Intensive Crit Care Nurs. 1993 Sep;9(3):195-200. doi: 10.1016/0964-3397(93)90027-u. |
| 25160838 | Background | Donovan KA, Grassi L, McGinty HL, Jacobsen PB. Validation of the distress thermometer worldwide: state of the science. Psychooncology. 2014 Mar;23(3):241-50. doi: 10.1002/pon.3430. Epub 2013 Nov 11. |
| 33293201 | Background | Dincer B, Inangil D. The effect of Emotional Freedom Techniques on nurses' stress, anxiety, and burnout levels during the COVID-19 pandemic: A randomized controlled trial. Explore (NY). 2021 Mar-Apr;17(2):109-114. doi: 10.1016/j.explore.2020.11.012. Epub 2020 Dec 3. |
| 37429762 | Background | Bal SK, Gun M. The effects of acupressure on pain, anxiety and vital signs in patients undergoing coronary angiography: A randomized and sham-controlled trial. Explore (NY). 2024 Jan-Feb;20(1):101-109. doi: 10.1016/j.explore.2023.07.001. Epub 2023 Jul 4. |
| 39595461 | Background | Amiri S, Mahmood N, Javaid SF, Khan MA. The Effect of Lifestyle Interventions on Anxiety, Depression and Stress: A Systematic Review and Meta-Analysis of Randomized Clinical Trials. Healthcare (Basel). 2024 Nov 13;12(22):2263. doi: 10.3390/healthcare12222263. |
| 39942410 | Background | Alghamdi R, Bahari G. Shift Work, Psychological Health Disorders, and Job Security Among Nurses: A Cross-Sectional Study. Healthcare (Basel). 2025 Jan 22;13(3):221. doi: 10.3390/healthcare13030221. |
| 39297814 | Background | Turkili S, Karaman A, Cam Yanik T, Altun Ugras G, Yuksel S, Turkili S, Tasdelen B. The Effects of Acupressure on Preoperative Anxiety, Postoperative Pain, and Nausea and Vomiting in Otolaryngology Patients. J Perianesth Nurs. 2025 Apr;40(2):385-392. doi: 10.1016/j.jopan.2024.05.027. Epub 2024 Sep 19. |
| 35060955 | Result | Zeiher W, Sego E, Trimmer D, Bowers C. Posttraumatic Stress Disorder in Nurses During a Pandemic: Implications for Nurse Leaders. J Nurs Adm. 2022 Feb 1;52(2):E3-E8. doi: 10.1097/NNA.0000000000001112. |
| 35111587 | Result | Lin J, Chen T, He J, Chung RC, Ma H, Tsang H. Impacts of acupressure treatment on depression: A systematic review and meta-analysis. World J Psychiatry. 2022 Jan 19;12(1):169-186. doi: 10.5498/wjp.v12.i1.169. eCollection 2022 Jan 19. |
| 39744118 | Result | Liang R, Tang L, Li L, Zhao N, Yu X, Li J, Wang Q, Cun H, Gao X, Yang W. The effect of pressing needle therapy on depression, anxiety, and sleep for patients in convalescence from COVID-19. Front Neurol. 2024 Dec 18;15:1481557. doi: 10.3389/fneur.2024.1481557. eCollection 2024. |
| 20206838 | Result | Lee JI, Lee MB, Liao SC, Chang CM, Sung SC, Chiang HC, Tai CW. Prevalence of suicidal ideation and associated risk factors in the general population. J Formos Med Assoc. 2010 Feb;109(2):138-47. doi: 10.1016/S0929-6646(10)60034-4. |
| 40150432 | Result | Katsiroumpa A, Moisoglou I, Papathanasiou IV, Malliarou M, Sarafis P, Gallos P, Konstantakopoulou O, Rizos F, Galanis P. Resilience and Social Support Protect Nurses from Anxiety and Depressive Symptoms: Evidence from a Cross-Sectional Study in the Post-COVID-19 Era. Healthcare (Basel). 2025 Mar 7;13(6):582. doi: 10.3390/healthcare13060582. |
| A survey on the current status of resilience among healthcare professionals and the development of a resilience scale: A sample from a hospital in southern Taiwan. | View source |
| Epidemiological survey of depressive disorder in Kaohsiung Metropolis: Development of a culture-relevant Taiwanese Depression Screening Questionnaire. | View source |
| Using the BSRS-5 to predict suicidal ideation among community residents. | View source |
| Development and validation of the Chinese version of the Copenhagen Burnout Inventory. | View source |
| BG002 | Total | Total of all reporting groups |
After collecting the data of 160 subjects, we will analyze them into MEAN and Standard Deviation to see the overall distribution.
| Mean |
| Standard Deviation |
| years |
|
| Sex: Female, Male | 160 subjects filled in the proportion of each group according to gender | Use percentages to look at the distribution of male and female students in the control and intervention groups. | Count of Participants | Participants | No |
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| Race and Ethnicity Not Collected | Race and Ethnicity were not collected from any participant. | Count of Participants | Participants |
|
| Region of Enrollment | The 160 subjects were mainly clinical nurses at Kaohsiung Veterans General Hospital in Taiwan. | All 160 subjects were admitted in Taiwan, so the number of people can be used to represent it. | Count of Participants | Participants | No |
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| Primary | Psychological Distress | Psychological distress was measured using the Brief Symptom Rating Scale-5 (BSRS-5), a validated screening tool for general psychological distress. The BSRS-5 assesses the subjective severity of the following symptoms: (1) anxiety, (2) depression, (3) hostility, (4) low self-esteem, and (5) insomnia. Each symptom was scored on a 5-point Likert scale, ranging from 0 ("not at all") to 4 ("extremely"), with a total score ranging from 0 to 20 points. Higher scores indicate more severe psychological distress. Studies have shown that a total score of 3-4 is the optimal threshold for identifying clinically relevant distress based on receiver operating characteristic (ROC) curve analysis. The BSRS-5 showed high accuracy (AUC = 0.92) and good sensitivity (0.83) and specificity (0.86). Therefore, this study used a BSRS-5 total score ≥4 as one of the inclusion criteria to ensure that participants with at least mild psychological distress were included in the study. | After the pre-test questionnaire assessment (baseline week 0), the subjects (control group/intervention group) will be followed up with weekly questionnaires for eight weeks (weeks 1 to 8) after the start of the program, of which the Mood Thermometer (Brief Symptoms Rating Scale, BSRS-5) questionnaire will obtain data for a total of nine weeks (baseline week 0 and follow-up weeks 1 to 8) and conduct data analysis. | Posted | Mean | Standard Deviation | score on a scale | At baseline(weeks 0) and once weekly for 8 weeks(weeks 1-8) |
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| Secondary | Resilience | This scale assesses an individual's ability to adapt and recover from stress and adversity. Each item is rated on a 5-point Likert scale, ranging from 1 ("strongly disagree") to 5 ("strongly agree"), with a total score ranging from 10 to 50, with higher scores indicating greater resilience. Initial validation studies demonstrated strong psychometric properties, including good model fit in confirmatory factor analysis (GFI = 0.973) and excellent internal consistency (Cronbach's α = .91). All instruments used in this study were authorized by their original developers and have been psychometrically validated in previous studies. All scales demonstrated good to excellent internal consistency, with Cronbach's α values ranging from 0.84 to 0.95. | After the pre-test questionnaire assessment (baseline week 0), the subjects (control group/intervention group) will be followed up with weekly questionnaires for eight weeks (weeks 1 to 8) after the start of the program, of which the Resilience questionnaire will obtain data for a total of nine weeks (baseline week 0 and follow-up weeks 1 to 8) and conduct data analysis. | Posted | Mean | Standard Deviation | score on a scale | At baseline(weeks 0) and once weekly for 8 weeks(weeks 1-8) |
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| Secondary | Anxiety | Anxiety levels were assessed using the state subscale of the State-Trait Anxiety Inventory (STAI-S). Studies have confirmed the multidimensional factor structure of the Chinese version of the scale and demonstrated good psychometric properties, including adequate convergent and discriminant validity. In this sample, the STAI-S demonstrated excellent internal consistency (Cronbach's α = .95). The STAI-S consists of 20 items that assess anxiety-related feelings, thoughts, and behaviors at the time of assessment. Each item is rated on a 4-point Likert scale ranging from 1 ("not at all") to 4 ("very much"). Items 1, 2, 5, 8, 10, 11, 15, 16, 19, and 20 are reverse-scored. The total score ranges from 20 to 80, with scores between 20 and 39 indicating mild anxiety, 40 to 59 indicating moderate anxiety, and 60 to 80 indicating severe anxiety. | After the pre-test questionnaire assessment (baseline week 0), the subjects (control group/intervention group) will be followed up with weekly questionnaires for eight weeks (weeks 1 to 8) after the start of the program. The anxiety questionnaire will obtain data for a total of nine weeks (baseline week 0 and follow-up weeks 1 to 8) and conduct data analysis. | Posted | Mean | Standard Deviation | score on a scale | At baseline(weeks 0) and once weekly for 8 weeks(weeks 1-8) |
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| Secondary | Job Stress | Perceived job stress was measured using the 14-item Work Pressure Inventory developed by Huang et al. (2017), which has demonstrated good internal consistency. The scale comprises three dimensions: low self-development, workload, and job characteristics. Each item is rated on a 5-point Likert scale ranging from 1 ("strongly disagree") to 5 ("strongly agree"), with total scores ranging from 14 to 70. Higher scores indicate greater perceived occupational stress. In the original validation study, the Cronbach's α coefficients for the three subscales were 0.81, 0.73, and 0.77, respectively. In the present study, the Work Pressure Inventory showed good overall internal consistency (Cronbach's α = .84). | After the pre-test questionnaire assessment (baseline week 0), the subjects (control group/intervention group) will be followed up with weekly questionnaires for eight weeks (weeks 1 to 8) after the start of the program. The Nurse Stress questionnaire will obtain data for a total of nine weeks (baseline week 0 and follow-up weeks 1 to 8) and conduct data analysis. | Posted | Mean | Standard Deviation | score on a scale | At baseline(weeks 0) and once weekly for 8 weeks(weeks 1-8) |
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| Secondary | Occupational Burnout | Occupational burnout was assessed using the Chinese version of the Copenhagen Burnout Inventory (CBI), which has demonstrated good psychometric properties in Taiwanese populations. The scale consists of four subscales: personal burnout, work-related burnout, client-related burnout, and overcommitment to work. Each item is rated on a five-point frequency scale: "always" (100), "often" (75), "sometimes" (50), "rarely" (25), and "never" (0). Subscale scores are calculated as the average of the items within each domain, ranging from 0 to 100, with higher scores indicating more severe occupational burnout. The original validation study reported Cronbach's α values above 0.84 across all subscales. In the present study, the scale demonstrated excellent internal consistency (Cronbach's α = .95). | After the pre-test questionnaire assessment (baseline week 0), the subjects (control group/intervention group) will be followed up with weekly questionnaires for eight weeks (weeks 1 to 8) after the start of the program. The workplace fatigue questionnaire will obtain data for a total of nine weeks (baseline week 0 and follow-up weeks 1 to 8) and conduct data analysis. | Posted | Mean | Standard Deviation | score on a scale | At baseline(weeks 0) and once weekly for 8 weeks(weeks 1-8) |
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| Secondary | Emotional Distress | Emotional distress was measured using the Distress Thermometer (DT), a single self-report screening instrument with a score range of 0 (no distress) to 10 (extreme distress), with higher scores indicating greater emotional distress. The DT demonstrated good psychometric properties in validation studies, with sensitivities ranging from 0.50 to 1.00 (median = 0.83) and specificities ranging from 0.36 to 0.98 (median = 0.68). This study used a DT cutoff score of ≥3 as the inclusion criterion. Other studies have shown that the optimal DT cutoff score varies across settings, typically ranging from 3 to 5, while thresholds of ≥4 or ≥5 are commonly used in clinical practice. The use of a score of ≥3 in this study was intended to maximize sensitivity and minimize the risk of underidentifying caregivers considered at high risk for psychological distress. | After the pre-test questionnaire assessment (baseline week 0), the subjects (control group/intervention group) will be followed up with weekly questionnaires for eight weeks (weeks 1 to 8) after the start of the program. A total of nine weeks (baseline week 0 and follow-up weeks 1 to 8) of Distress Thermometer questionnaire data will be obtained and analyzed. | Posted | Mean | Standard Deviation | score on a scale | At baseline(weeks 0) and once weekly for 8 weeks(weeks 1-8) |
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| 80 |
| 0 |
| 80 |
| 0 |
| 80 |
| EG001 | Intervention Group (Acupressure) | From enrollment until end of follow-up, up to 8 weeks. | 0 | 80 | 0 | 80 | 0 | 80 |
Not provided
Not provided
Not provided
| D013315 |
| Stress, Psychological |
| D000077062 | Burnout, Psychological |
| D026741 | Physical Therapy Modalities |
| D012046 | Rehabilitation |
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| Other |
A generalized estimating equation (GEE) model included group (intervention group vs. control group), week (categorical: 0-8), group × week interaction, and age as covariates. Robust (sandwich) standard errors were used. Regression coefficients (B), standard errors, Wald chi-squared statistics, 95% confidence intervals, and p-values for group × week comparisons are reported. |
| Generalized estimating equations (GEE) were chosen over repeated-measures analysis of variance or generalized linear mixed models because they provide estimates of the population mean, are robust to correlated error specifications, can accommodate missing data under the MAR/MCAR assumptions, and do not require sphericity. All tests were two-tailed, with α = 0.05. | Generalized Estimating Equations, GEE | Repeated-measures GEE was used to examine the group × time interaction between week 0 and week 2. | 0.608 | This is the second week of tracking data. A P value < 0.05 indicated a statistically significant difference. | Other | A generalized estimating equation (GEE) model included group (intervention group vs. control group), week (categorical: 0-8), group × week interaction, and age as covariates. Robust (sandwich) standard errors were used. Regression coefficients (B), standard errors, Wald chi-squared statistics, 95% confidence intervals, and p-values for group × week comparisons are reported. |
| Generalized estimating equations (GEE) were chosen over repeated-measures analysis of variance or generalized linear mixed models because they provide estimates of the population mean, are robust to correlated error specifications, can accommodate missing data under the MAR/MCAR assumptions, and do not require sphericity. All tests were two-tailed, with α = 0.05. | Generalized Estimating Equations, GEE | Repeated-measures GEE was used to examine the group × time interaction between week 0 and week 3. | 0.244 | This is the third week of tracking data. A P value < 0.05 indicated a statistically significant difference. | Other | A generalized estimating equation (GEE) model included group (intervention group vs. control group), week (categorical: 0-8), group × week interaction, and age as covariates. Robust (sandwich) standard errors were used. Regression coefficients (B), standard errors, Wald chi-squared statistics, 95% confidence intervals, and p-values for group × week comparisons are reported. |
| Generalized estimating equations (GEE) were chosen over repeated-measures analysis of variance or generalized linear mixed models because they provide estimates of the population mean, are robust to correlated error specifications, can accommodate missing data under the MAR/MCAR assumptions, and do not require sphericity. All tests were two-tailed, with α = 0.05. | Generalized Estimating Equations, GEE | Repeated-measures GEE was used to examine the group × time interaction between week 0 and week 4. | 0.052 | This is the fourth week of tracking data. A P value < 0.05 indicated a statistically significant difference. | Other | A generalized estimating equation (GEE) model included group (intervention group vs. control group), week (categorical: 0-8), group × week interaction, and age as covariates. Robust (sandwich) standard errors were used. Regression coefficients (B), standard errors, Wald chi-squared statistics, 95% confidence intervals, and p-values for group × week comparisons are reported. |
| Generalized estimating equations (GEE) were chosen over repeated-measures analysis of variance or generalized linear mixed models because they provide estimates of the population mean, are robust to correlated error specifications, can accommodate missing data under the MAR/MCAR assumptions, and do not require sphericity. All tests were two-tailed, with α = 0.05. | Generalized Estimating Equations, GEE | Repeated-measures GEE was used to examine the group × time interaction between week 0 and week 5. | 0.229 | This is the fifth week of tracking data. A P value < 0.05 indicated a statistically significant difference. | Other | A generalized estimating equation (GEE) model included group (intervention group vs. control group), week (categorical: 0-8), group × week interaction, and age as covariates. Robust (sandwich) standard errors were used. Regression coefficients (B), standard errors, Wald chi-squared statistics, 95% confidence intervals, and p-values for group × week comparisons are reported. |
| Generalized estimating equations (GEE) were chosen over repeated-measures analysis of variance or generalized linear mixed models because they provide estimates of the population mean, are robust to correlated error specifications, can accommodate missing data under the MAR/MCAR assumptions, and do not require sphericity. All tests were two-tailed, with α = 0.05. | Generalized Estimating Equations, GEE | Repeated-measures GEE was used to examine the group × time interaction between week 0 and week 6. | 0.184 | This is the sixth week of tracking data. A P value < 0.05 indicated a statistically significant difference. | Other | A generalized estimating equation (GEE) model included group (intervention group vs. control group), week (categorical: 0-8), group × week interaction, and age as covariates. Robust (sandwich) standard errors were used. Regression coefficients (B), standard errors, Wald chi-squared statistics, 95% confidence intervals, and p-values for group × week comparisons are reported. |
| Generalized estimating equations (GEE) were chosen over repeated-measures analysis of variance or generalized linear mixed models because they provide estimates of the population mean, are robust to correlated error specifications, can accommodate missing data under the MAR/MCAR assumptions, and do not require sphericity. All tests were two-tailed, with α = 0.05. | Generalized Estimating Equations, GEE | Repeated-measures GEE was used to examine the group × time interaction between week 0 and week 7. | 0.148 | This is the seventh week of tracking data. A P value < 0.05 indicated a statistically significant difference. | Other | A generalized estimating equation (GEE) model included group (intervention group vs. control group), week (categorical: 0-8), group × week interaction, and age as covariates. Robust (sandwich) standard errors were used. Regression coefficients (B), standard errors, Wald chi-squared statistics, 95% confidence intervals, and p-values for group × week comparisons are reported. |
| Generalized estimating equations (GEE) were chosen over repeated-measures analysis of variance or generalized linear mixed models because they provide estimates of the population mean, are robust to correlated error specifications, can accommodate missing data under the MAR/MCAR assumptions, and do not require sphericity. All tests were two-tailed, with α = 0.05. | Generalized Estimating Equations, GEE | Repeated-measures GEE was used to examine the group × time interaction between week 0 and week 8. | 0.143 | This is the eighth week of tracking data. A P value < 0.05 indicated a statistically significant difference. | Other | A generalized estimating equation (GEE) model included group (intervention group vs. control group), week (categorical: 0-8), group × week interaction, and age as covariates. Robust (sandwich) standard errors were used. Regression coefficients (B), standard errors, Wald chi-squared statistics, 95% confidence intervals, and p-values for group × week comparisons are reported. |
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A generalized estimating equation (GEE) model included group (intervention group vs. control group), week (categorical: 0-8), group × week interaction, and age as covariates. Robust (sandwich) standard errors were used. Regression coefficients (B), standard errors, Wald chi-squared statistics, 95% confidence intervals, and p-values for group × week comparisons are reported. |
| Generalized estimating equations (GEE) were chosen over repeated-measures analysis of variance or generalized linear mixed models because they provide estimates of the population mean, are robust to correlated error specifications, can accommodate missing data under the MAR/MCAR assumptions, and do not require sphericity. All tests were two-tailed, with α = 0.05. | Generalized Estimating Equations, GEE | Repeated-measures GEE was used to examine the group × time interaction between week 0 and week 2. | 0.273 | This is the second week of tracking data. A P value < 0.05 indicated a statistically significant difference. | Other | A generalized estimating equation (GEE) model included group (intervention group vs. control group), week (categorical: 0-8), group × week interaction, and age as covariates. Robust (sandwich) standard errors were used. Regression coefficients (B), standard errors, Wald chi-squared statistics, 95% confidence intervals, and p-values for group × week comparisons are reported. |
| Generalized estimating equations (GEE) were chosen over repeated-measures analysis of variance or generalized linear mixed models because they provide estimates of the population mean, are robust to correlated error specifications, can accommodate missing data under the MAR/MCAR assumptions, and do not require sphericity. All tests were two-tailed, with α = 0.05. | Generalized Estimating Equations, GEE | Repeated-measures GEE was used to examine the group × time interaction between week 0 and week 3. | 0.424 | This is the third week of tracking data. A P value < 0.05 indicated a statistically significant difference. | Other | A generalized estimating equation (GEE) model included group (intervention group vs. control group), week (categorical: 0-8), group × week interaction, and age as covariates. Robust (sandwich) standard errors were used. Regression coefficients (B), standard errors, Wald chi-squared statistics, 95% confidence intervals, and p-values for group × week comparisons are reported. |
| Generalized estimating equations (GEE) were chosen over repeated-measures analysis of variance or generalized linear mixed models because they provide estimates of the population mean, are robust to correlated error specifications, can accommodate missing data under the MAR/MCAR assumptions, and do not require sphericity. All tests were two-tailed, with α = 0.05. | Generalized Estimating Equations, GEE | Repeated-measures GEE was used to examine the group × time interaction between week 0 and week 4. | 0.482 | This is the fourth week of tracking data. A P value < 0.05 indicated a statistically significant difference. | Other | A generalized estimating equation (GEE) model included group (intervention group vs. control group), week (categorical: 0-8), group × week interaction, and age as covariates. Robust (sandwich) standard errors were used. Regression coefficients (B), standard errors, Wald chi-squared statistics, 95% confidence intervals, and p-values for group × week comparisons are reported. |
| Generalized estimating equations (GEE) were chosen over repeated-measures analysis of variance or generalized linear mixed models because they provide estimates of the population mean, are robust to correlated error specifications, can accommodate missing data under the MAR/MCAR assumptions, and do not require sphericity. All tests were two-tailed, with α = 0.05. | Generalized Estimating Equations, GEE | Repeated-measures GEE was used to examine the group × time interaction between week 0 and week 5. | 0.627 | This is the fifth week of tracking data. A P value < 0.05 indicated a statistically significant difference. | Other | A generalized estimating equation (GEE) model included group (intervention group vs. control group), week (categorical: 0-8), group × week interaction, and age as covariates. Robust (sandwich) standard errors were used. Regression coefficients (B), standard errors, Wald chi-squared statistics, 95% confidence intervals, and p-values for group × week comparisons are reported. |
| Generalized estimating equations (GEE) were chosen over repeated-measures analysis of variance or generalized linear mixed models because they provide estimates of the population mean, are robust to correlated error specifications, can accommodate missing data under the MAR/MCAR assumptions, and do not require sphericity. All tests were two-tailed, with α = 0.05. | Generalized Estimating Equations, GEE | Repeated-measures GEE was used to examine the group × time interaction between week 0 and week 6. | 0.806 | This is the sixth week of tracking data. A P value < 0.05 indicated a statistically significant difference. | Other | A generalized estimating equation (GEE) model included group (intervention group vs. control group), week (categorical: 0-8), group × week interaction, and age as covariates. Robust (sandwich) standard errors were used. Regression coefficients (B), standard errors, Wald chi-squared statistics, 95% confidence intervals, and p-values for group × week comparisons are reported. |
| Generalized estimating equations (GEE) were chosen over repeated-measures analysis of variance or generalized linear mixed models because they provide estimates of the population mean, are robust to correlated error specifications, can accommodate missing data under the MAR/MCAR assumptions, and do not require sphericity. All tests were two-tailed, with α = 0.05. | Generalized Estimating Equations, GEE | Repeated-measures GEE was used to examine the group × time interaction between week 0 and week 7. | 0.786 | This is the seventh week of tracking data. A P value < 0.05 indicated a statistically significant difference. | Other | A generalized estimating equation (GEE) model included group (intervention group vs. control group), week (categorical: 0-8), group × week interaction, and age as covariates. Robust (sandwich) standard errors were used. Regression coefficients (B), standard errors, Wald chi-squared statistics, 95% confidence intervals, and p-values for group × week comparisons are reported. |
| Generalized estimating equations (GEE) were chosen over repeated-measures analysis of variance or generalized linear mixed models because they provide estimates of the population mean, are robust to correlated error specifications, can accommodate missing data under the MAR/MCAR assumptions, and do not require sphericity. All tests were two-tailed, with α = 0.05. | Generalized Estimating Equations, GEE | Repeated-measures GEE was used to examine the group × time interaction between week 0 and week 8. | 0.497 | This is the eighth week of tracking data. A P value < 0.05 indicated a statistically significant difference. | Other | A generalized estimating equation (GEE) model included group (intervention group vs. control group), week (categorical: 0-8), group × week interaction, and age as covariates. Robust (sandwich) standard errors were used. Regression coefficients (B), standard errors, Wald chi-squared statistics, 95% confidence intervals, and p-values for group × week comparisons are reported. |
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| Other |
A generalized estimating equation (GEE) model included group (intervention group vs. control group), week (categorical: 0-8), group × week interaction, and age as covariates. Robust (sandwich) standard errors were used. Regression coefficients (B), standard errors, Wald chi-squared statistics, 95% confidence intervals, and p-values for group × week comparisons are reported. |
| Generalized estimating equations (GEE) were chosen over repeated-measures analysis of variance or generalized linear mixed models because they provide estimates of the population mean, are robust to correlated error specifications, can accommodate missing data under the MAR/MCAR assumptions, and do not require sphericity. All tests were two-tailed, with α = 0.05. | Generalized Estimating Equations, GEE | Repeated-measures GEE was used to examine the group × time interaction between week 0 and week 2. | 0.684 | This is the second week of tracking data. A P value < 0.05 indicated a statistically significant difference. | Other | A generalized estimating equation (GEE) model included group (intervention group vs. control group), week (categorical: 0-8), group × week interaction, and age as covariates. Robust (sandwich) standard errors were used. Regression coefficients (B), standard errors, Wald chi-squared statistics, 95% confidence intervals, and p-values for group × week comparisons are reported. |
| Generalized estimating equations (GEE) were chosen over repeated-measures analysis of variance or generalized linear mixed models because they provide estimates of the population mean, are robust to correlated error specifications, can accommodate missing data under the MAR/MCAR assumptions, and do not require sphericity. All tests were two-tailed, with α = 0.05. | Generalized Estimating Equations, GEE | Repeated-measures GEE was used to examine the group × time interaction between week 0 and week 3. | 0.333 | This is the third week of tracking data. A P value < 0.05 indicated a statistically significant difference. | Other | A generalized estimating equation (GEE) model included group (intervention group vs. control group), week (categorical: 0-8), group × week interaction, and age as covariates. Robust (sandwich) standard errors were used. Regression coefficients (B), standard errors, Wald chi-squared statistics, 95% confidence intervals, and p-values for group × week comparisons are reported. |
| Generalized estimating equations (GEE) were chosen over repeated-measures analysis of variance or generalized linear mixed models because they provide estimates of the population mean, are robust to correlated error specifications, can accommodate missing data under the MAR/MCAR assumptions, and do not require sphericity. All tests were two-tailed, with α = 0.05. | Generalized Estimating Equations, GEE | Repeated-measures GEE was used to examine the group × time interaction between week 0 and week 4. | 0.090 | This is the fourth week of tracking data. A P value < 0.05 indicated a statistically significant difference. | Other | A generalized estimating equation (GEE) model included group (intervention group vs. control group), week (categorical: 0-8), group × week interaction, and age as covariates. Robust (sandwich) standard errors were used. Regression coefficients (B), standard errors, Wald chi-squared statistics, 95% confidence intervals, and p-values for group × week comparisons are reported. |
| Generalized estimating equations (GEE) were chosen over repeated-measures analysis of variance or generalized linear mixed models because they provide estimates of the population mean, are robust to correlated error specifications, can accommodate missing data under the MAR/MCAR assumptions, and do not require sphericity. All tests were two-tailed, with α = 0.05. | Generalized Estimating Equations, GEE | Repeated-measures GEE was used to examine the group × time interaction between week 0 and week 5. | 0.545 | This is the fifth week of tracking data. A P value < 0.05 indicated a statistically significant difference. | Other | A generalized estimating equation (GEE) model included group (intervention group vs. control group), week (categorical: 0-8), group × week interaction, and age as covariates. Robust (sandwich) standard errors were used. Regression coefficients (B), standard errors, Wald chi-squared statistics, 95% confidence intervals, and p-values for group × week comparisons are reported. |
| Generalized estimating equations (GEE) were chosen over repeated-measures analysis of variance or generalized linear mixed models because they provide estimates of the population mean, are robust to correlated error specifications, can accommodate missing data under the MAR/MCAR assumptions, and do not require sphericity. All tests were two-tailed, with α = 0.05. | Generalized Estimating Equations, GEE | Repeated-measures GEE was used to examine the group × time interaction between week 0 and week 6. | 0.251 | This is the sixth week of tracking data. A P value < 0.05 indicated a statistically significant difference. | Other | A generalized estimating equation (GEE) model included group (intervention group vs. control group), week (categorical: 0-8), group × week interaction, and age as covariates. Robust (sandwich) standard errors were used. Regression coefficients (B), standard errors, Wald chi-squared statistics, 95% confidence intervals, and p-values for group × week comparisons are reported. |
| Generalized estimating equations (GEE) were chosen over repeated-measures analysis of variance or generalized linear mixed models because they provide estimates of the population mean, are robust to correlated error specifications, can accommodate missing data under the MAR/MCAR assumptions, and do not require sphericity. All tests were two-tailed, with α = 0.05. | Generalized Estimating Equations, GEE | Repeated-measures GEE was used to examine the group × time interaction between week 0 and week 7. | 0.701 | This is the seventh week of tracking data. A P value < 0.05 indicated a statistically significant difference. | Other | A generalized estimating equation (GEE) model included group (intervention group vs. control group), week (categorical: 0-8), group × week interaction, and age as covariates. Robust (sandwich) standard errors were used. Regression coefficients (B), standard errors, Wald chi-squared statistics, 95% confidence intervals, and p-values for group × week comparisons are reported. |
| Generalized estimating equations (GEE) were chosen over repeated-measures analysis of variance or generalized linear mixed models because they provide estimates of the population mean, are robust to correlated error specifications, can accommodate missing data under the MAR/MCAR assumptions, and do not require sphericity. All tests were two-tailed, with α = 0.05. | Generalized Estimating Equations, GEE | Repeated-measures GEE was used to examine the group × time interaction between week 0 and week 8. | 0.080 | This is the eighth week of tracking data. A P value < 0.05 indicated a statistically significant difference. | Other | A generalized estimating equation (GEE) model included group (intervention group vs. control group), week (categorical: 0-8), group × week interaction, and age as covariates. Robust (sandwich) standard errors were used. Regression coefficients (B), standard errors, Wald chi-squared statistics, 95% confidence intervals, and p-values for group × week comparisons are reported. |
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| Other |
A generalized estimating equation (GEE) model included group (intervention group vs. control group), week (categorical: 0-8), group × week interaction, and age as covariates. Robust (sandwich) standard errors were used. Regression coefficients (B), standard errors, Wald chi-squared statistics, 95% confidence intervals, and p-values for group × week comparisons are reported. |
| Generalized estimating equations (GEE) were chosen over repeated-measures analysis of variance or generalized linear mixed models because they provide estimates of the population mean, are robust to correlated error specifications, can accommodate missing data under the MAR/MCAR assumptions, and do not require sphericity. All tests were two-tailed, with α = 0.05. | Generalized Estimating Equations, GEE | Repeated-measures GEE was used to examine the group × time interaction between week 0 and week 2. | 0.909 | This is the second week of tracking data. A P value < 0.05 indicated a statistically significant difference. | Other | A generalized estimating equation (GEE) model included group (intervention group vs. control group), week (categorical: 0-8), group × week interaction, and age as covariates. Robust (sandwich) standard errors were used. Regression coefficients (B), standard errors, Wald chi-squared statistics, 95% confidence intervals, and p-values for group × week comparisons are reported. |
| Generalized estimating equations (GEE) were chosen over repeated-measures analysis of variance or generalized linear mixed models because they provide estimates of the population mean, are robust to correlated error specifications, can accommodate missing data under the MAR/MCAR assumptions, and do not require sphericity. All tests were two-tailed, with α = 0.05. | Generalized Estimating Equations, GEE | Repeated-measures GEE was used to examine the group × time interaction between week 0 and week 3. | 0.627 | This is the third week of tracking data. A P value < 0.05 indicated a statistically significant difference. | Other | A generalized estimating equation (GEE) model included group (intervention group vs. control group), week (categorical: 0-8), group × week interaction, and age as covariates. Robust (sandwich) standard errors were used. Regression coefficients (B), standard errors, Wald chi-squared statistics, 95% confidence intervals, and p-values for group × week comparisons are reported. |
| Generalized estimating equations (GEE) were chosen over repeated-measures analysis of variance or generalized linear mixed models because they provide estimates of the population mean, are robust to correlated error specifications, can accommodate missing data under the MAR/MCAR assumptions, and do not require sphericity. All tests were two-tailed, with α = 0.05. | Generalized Estimating Equations, GEE | Repeated-measures GEE was used to examine the group × time interaction between week 0 and week 4. | 0.474 | This is the fourth week of tracking data. A P value < 0.05 indicated a statistically significant difference. | Other | A generalized estimating equation (GEE) model included group (intervention group vs. control group), week (categorical: 0-8), group × week interaction, and age as covariates. Robust (sandwich) standard errors were used. Regression coefficients (B), standard errors, Wald chi-squared statistics, 95% confidence intervals, and p-values for group × week comparisons are reported. |
| Generalized estimating equations (GEE) were chosen over repeated-measures analysis of variance or generalized linear mixed models because they provide estimates of the population mean, are robust to correlated error specifications, can accommodate missing data under the MAR/MCAR assumptions, and do not require sphericity. All tests were two-tailed, with α = 0.05. | Generalized Estimating Equations, GEE | Repeated-measures GEE was used to examine the group × time interaction between week 0 and week 5. | 0.378 | This is the fifth week of tracking data. A P value < 0.05 indicated a statistically significant difference. | Other | A generalized estimating equation (GEE) model included group (intervention group vs. control group), week (categorical: 0-8), group × week interaction, and age as covariates. Robust (sandwich) standard errors were used. Regression coefficients (B), standard errors, Wald chi-squared statistics, 95% confidence intervals, and p-values for group × week comparisons are reported. |
| Generalized estimating equations (GEE) were chosen over repeated-measures analysis of variance or generalized linear mixed models because they provide estimates of the population mean, are robust to correlated error specifications, can accommodate missing data under the MAR/MCAR assumptions, and do not require sphericity. All tests were two-tailed, with α = 0.05. | Generalized Estimating Equations, GEE | Repeated-measures GEE was used to examine the group × time interaction between week 0 and week 6. | 0.768 | This is the sixth week of tracking data. A P value < 0.05 indicated a statistically significant difference. | Other | A generalized estimating equation (GEE) model included group (intervention group vs. control group), week (categorical: 0-8), group × week interaction, and age as covariates. Robust (sandwich) standard errors were used. Regression coefficients (B), standard errors, Wald chi-squared statistics, 95% confidence intervals, and p-values for group × week comparisons are reported. |
| Generalized estimating equations (GEE) were chosen over repeated-measures analysis of variance or generalized linear mixed models because they provide estimates of the population mean, are robust to correlated error specifications, can accommodate missing data under the MAR/MCAR assumptions, and do not require sphericity. All tests were two-tailed, with α = 0.05. | Generalized Estimating Equations, GEE | Repeated-measures GEE was used to examine the group × time interaction between week 0 and week 7. | 0.909 | This is the seventh week of tracking data. A P value < 0.05 indicated a statistically significant difference. | Other | A generalized estimating equation (GEE) model included group (intervention group vs. control group), week (categorical: 0-8), group × week interaction, and age as covariates. Robust (sandwich) standard errors were used. Regression coefficients (B), standard errors, Wald chi-squared statistics, 95% confidence intervals, and p-values for group × week comparisons are reported. |
| Generalized estimating equations (GEE) were chosen over repeated-measures analysis of variance or generalized linear mixed models because they provide estimates of the population mean, are robust to correlated error specifications, can accommodate missing data under the MAR/MCAR assumptions, and do not require sphericity. All tests were two-tailed, with α = 0.05. | Generalized Estimating Equations, GEE | Repeated-measures GEE was used to examine the group × time interaction between week 0 and week 8. | 0.449 | This is the eighth week of tracking data. A P value < 0.05 indicated a statistically significant difference. | Other | A generalized estimating equation (GEE) model included group (intervention group vs. control group), week (categorical: 0-8), group × week interaction, and age as covariates. Robust (sandwich) standard errors were used. Regression coefficients (B), standard errors, Wald chi-squared statistics, 95% confidence intervals, and p-values for group × week comparisons are reported. |
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| Tracking Week 0 |
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| Other |
A generalized estimating equation (GEE) model included group (intervention group vs. control group), week (categorical: 0-8), group × week interaction, and age as covariates. Robust (sandwich) standard errors were used. Regression coefficients (B), standard errors, Wald chi-squared statistics, 95% confidence intervals, and p-values for group × week comparisons are reported. |
| Generalized estimating equations (GEE) were chosen over repeated-measures analysis of variance or generalized linear mixed models because they provide estimates of the population mean, are robust to correlated error specifications, can accommodate missing data under the MAR/MCAR assumptions, and do not require sphericity. All tests were two-tailed, with α = 0.05. | Generalized Estimating Equations, GEE | Repeated-measures GEE was used to examine the group × time interaction between week 0 and week 2. | 0.994 | This is the second week of tracking data. A P value < 0.05 indicated a statistically significant difference. | Other | A generalized estimating equation (GEE) model included group (intervention group vs. control group), week (categorical: 0-8), group × week interaction, and age as covariates. Robust (sandwich) standard errors were used. Regression coefficients (B), standard errors, Wald chi-squared statistics, 95% confidence intervals, and p-values for group × week comparisons are reported. |
| Generalized estimating equations (GEE) were chosen over repeated-measures analysis of variance or generalized linear mixed models because they provide estimates of the population mean, are robust to correlated error specifications, can accommodate missing data under the MAR/MCAR assumptions, and do not require sphericity. All tests were two-tailed, with α = 0.05. | Generalized Estimating Equations, GEE | Repeated-measures GEE was used to examine the group × time interaction between week 0 and week 3. | 0.959 | This is the third week of tracking data. A P value < 0.05 indicated a statistically significant difference. | Other | A generalized estimating equation (GEE) model included group (intervention group vs. control group), week (categorical: 0-8), group × week interaction, and age as covariates. Robust (sandwich) standard errors were used. Regression coefficients (B), standard errors, Wald chi-squared statistics, 95% confidence intervals, and p-values for group × week comparisons are reported. |
| Generalized estimating equations (GEE) were chosen over repeated-measures analysis of variance or generalized linear mixed models because they provide estimates of the population mean, are robust to correlated error specifications, can accommodate missing data under the MAR/MCAR assumptions, and do not require sphericity. All tests were two-tailed, with α = 0.05. | Generalized Estimating Equations, GEE | Repeated-measures GEE was used to examine the group × time interaction between week 0 and week 4. | 0.946 | This is the fourth week of tracking data. A P value < 0.05 indicated a statistically significant difference. | Other | A generalized estimating equation (GEE) model included group (intervention group vs. control group), week (categorical: 0-8), group × week interaction, and age as covariates. Robust (sandwich) standard errors were used. Regression coefficients (B), standard errors, Wald chi-squared statistics, 95% confidence intervals, and p-values for group × week comparisons are reported. |
| Generalized estimating equations (GEE) were chosen over repeated-measures analysis of variance or generalized linear mixed models because they provide estimates of the population mean, are robust to correlated error specifications, can accommodate missing data under the MAR/MCAR assumptions, and do not require sphericity. All tests were two-tailed, with α = 0.05. | Generalized Estimating Equations, GEE | Repeated-measures GEE was used to examine the group × time interaction between week 0 and week 5. | 0.715 | This is the fifth week of tracking data. A P value < 0.05 indicated a statistically significant difference. | Other | A generalized estimating equation (GEE) model included group (intervention group vs. control group), week (categorical: 0-8), group × week interaction, and age as covariates. Robust (sandwich) standard errors were used. Regression coefficients (B), standard errors, Wald chi-squared statistics, 95% confidence intervals, and p-values for group × week comparisons are reported. |
| Generalized estimating equations (GEE) were chosen over repeated-measures analysis of variance or generalized linear mixed models because they provide estimates of the population mean, are robust to correlated error specifications, can accommodate missing data under the MAR/MCAR assumptions, and do not require sphericity. All tests were two-tailed, with α = 0.05. | Generalized Estimating Equations, GEE | Repeated-measures GEE was used to examine the group × time interaction between week 0 and week 6. | 0.422 | This is the sixth week of tracking data. A P value < 0.05 indicated a statistically significant difference. | Other | A generalized estimating equation (GEE) model included group (intervention group vs. control group), week (categorical: 0-8), group × week interaction, and age as covariates. Robust (sandwich) standard errors were used. Regression coefficients (B), standard errors, Wald chi-squared statistics, 95% confidence intervals, and p-values for group × week comparisons are reported. |
| Generalized estimating equations (GEE) were chosen over repeated-measures analysis of variance or generalized linear mixed models because they provide estimates of the population mean, are robust to correlated error specifications, can accommodate missing data under the MAR/MCAR assumptions, and do not require sphericity. All tests were two-tailed, with α = 0.05. | Generalized Estimating Equations, GEE | Repeated-measures GEE was used to examine the group × time interaction between week 0 and week 7. | 0.379 | This is the seventh week of tracking data. A P value < 0.05 indicated a statistically significant difference. | Other | A generalized estimating equation (GEE) model included group (intervention group vs. control group), week (categorical: 0-8), group × week interaction, and age as covariates. Robust (sandwich) standard errors were used. Regression coefficients (B), standard errors, Wald chi-squared statistics, 95% confidence intervals, and p-values for group × week comparisons are reported. |
| Generalized estimating equations (GEE) were chosen over repeated-measures analysis of variance or generalized linear mixed models because they provide estimates of the population mean, are robust to correlated error specifications, can accommodate missing data under the MAR/MCAR assumptions, and do not require sphericity. All tests were two-tailed, with α = 0.05. | Generalized Estimating Equations, GEE | Repeated-measures GEE was used to examine the group × time interaction between week 0 and week 8. | 0.302 | This is the eighth week of tracking data. A P value < 0.05 indicated a statistically significant difference. | Other | A generalized estimating equation (GEE) model included group (intervention group vs. control group), week (categorical: 0-8), group × week interaction, and age as covariates. Robust (sandwich) standard errors were used. Regression coefficients (B), standard errors, Wald chi-squared statistics, 95% confidence intervals, and p-values for group × week comparisons are reported. |
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| Tracking Week 0 |
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A generalized estimating equation (GEE) model included group (intervention group vs. control group), week (categorical: 0-8), group × week interaction, and age as covariates. Robust (sandwich) standard errors were used. Regression coefficients (B), standard errors, Wald chi-squared statistics, 95% confidence intervals, and p-values for group × week comparisons are reported. |
| Generalized estimating equations (GEE) were chosen over repeated-measures analysis of variance or generalized linear mixed models because they provide estimates of the population mean, are robust to correlated error specifications, can accommodate missing data under the MAR/MCAR assumptions, and do not require sphericity. All tests were two-tailed, with α = 0.05. | Generalized Estimating Equations, GEE | Repeated-measures GEE was used to examine the group × time interaction between week 0 and week 2. | 0.802 | This is the second week of tracking data. A P value < 0.05 indicated a statistically significant difference. | Other | A generalized estimating equation (GEE) model included group (intervention group vs. control group), week (categorical: 0-8), group × week interaction, and age as covariates. Robust (sandwich) standard errors were used. Regression coefficients (B), standard errors, Wald chi-squared statistics, 95% confidence intervals, and p-values for group × week comparisons are reported. |
| Generalized estimating equations (GEE) were chosen over repeated-measures analysis of variance or generalized linear mixed models because they provide estimates of the population mean, are robust to correlated error specifications, can accommodate missing data under the MAR/MCAR assumptions, and do not require sphericity. All tests were two-tailed, with α = 0.05. | Generalized Estimating Equations, GEE | Repeated-measures GEE was used to examine the group × time interaction between week 0 and week 3. | 0.605 | This is the third week of tracking data. A P value < 0.05 indicated a statistically significant difference. | Other | A generalized estimating equation (GEE) model included group (intervention group vs. control group), week (categorical: 0-8), group × week interaction, and age as covariates. Robust (sandwich) standard errors were used. Regression coefficients (B), standard errors, Wald chi-squared statistics, 95% confidence intervals, and p-values for group × week comparisons are reported. |
| Generalized Estimating Equations were used to analyze repeated measures data and to assess the interaction effect between group and time. Potential interfering factors such as age and years of work experience were controlled during the analysis, and the effect size (Cohen's d) and its 95% confidence interval were calculated to assist in interpreting the clinical significance. Statistical analysis was performed using SPSS version XX or R version XX, and the significance level was set at p < 0.05. | Generalized Estimating Equations, GEE | Repeated-measures GEE was used to examine the group × time interaction between week 0 and week 4. | 0.350 | This is the fourth week of tracking data. A P value < 0.05 indicated a statistically significant difference. | Other | A generalized estimating equation (GEE) model included group (intervention group vs. control group), week (categorical: 0-8), group × week interaction, and age as covariates. Robust (sandwich) standard errors were used. Regression coefficients (B), standard errors, Wald chi-squared statistics, 95% confidence intervals, and p-values for group × week comparisons are reported. |
| Generalized estimating equations (GEE) were chosen over repeated-measures analysis of variance or generalized linear mixed models because they provide estimates of the population mean, are robust to correlated error specifications, can accommodate missing data under the MAR/MCAR assumptions, and do not require sphericity. All tests were two-tailed, with α = 0.05. | Generalized Estimating Equations, GEE | Repeated-measures GEE was used to examine the group × time interaction between week 0 and week 5. | 1.000 | This is the fifth week of tracking data. A P value < 0.05 indicated a statistically significant difference. | Other | A generalized estimating equation (GEE) model included group (intervention group vs. control group), week (categorical: 0-8), group × week interaction, and age as covariates. Robust (sandwich) standard errors were used. Regression coefficients (B), standard errors, Wald chi-squared statistics, 95% confidence intervals, and p-values for group × week comparisons are reported. |
| Generalized estimating equations (GEE) were chosen over repeated-measures analysis of variance or generalized linear mixed models because they provide estimates of the population mean, are robust to correlated error specifications, can accommodate missing data under the MAR/MCAR assumptions, and do not require sphericity. All tests were two-tailed, with α = 0.05. | Generalized Estimating Equations, GEE | Repeated-measures GEE was used to examine the group × time interaction between week 0 and week 6. | 0.744 | This is the sixth week of tracking data. A P value < 0.05 indicated a statistically significant difference. | Other | A generalized estimating equation (GEE) model included group (intervention group vs. control group), week (categorical: 0-8), group × week interaction, and age as covariates. Robust (sandwich) standard errors were used. Regression coefficients (B), standard errors, Wald chi-squared statistics, 95% confidence intervals, and p-values for group × week comparisons are reported. |
| Generalized estimating equations (GEE) were chosen over repeated-measures analysis of variance or generalized linear mixed models because they provide estimates of the population mean, are robust to correlated error specifications, can accommodate missing data under the MAR/MCAR assumptions, and do not require sphericity. All tests were two-tailed, with α = 0.05. | Generalized Estimating Equations, GEE | Repeated-measures GEE was used to examine the group × time interaction between week 0 and week 7. | 0.202 | This is the seventh week of tracking data. A P value < 0.05 indicated a statistically significant difference. | Other | A generalized estimating equation (GEE) model included group (intervention group vs. control group), week (categorical: 0-8), group × week interaction, and age as covariates. Robust (sandwich) standard errors were used. Regression coefficients (B), standard errors, Wald chi-squared statistics, 95% confidence intervals, and p-values for group × week comparisons are reported. |
| Generalized estimating equations (GEE) were chosen over repeated-measures analysis of variance or generalized linear mixed models because they provide estimates of the population mean, are robust to correlated error specifications, can accommodate missing data under the MAR/MCAR assumptions, and do not require sphericity. All tests were two-tailed, with α = 0.05. | Generalized Estimating Equations, GEE | Repeated-measures GEE was used to examine the group × time interaction between week 0 and week 8. | 0.918 | This is the eighth week of tracking data. A P value < 0.05 indicated a statistically significant difference. | Other | A generalized estimating equation (GEE) model included group (intervention group vs. control group), week (categorical: 0-8), group × week interaction, and age as covariates. Robust (sandwich) standard errors were used. Regression coefficients (B), standard errors, Wald chi-squared statistics, 95% confidence intervals, and p-values for group × week comparisons are reported. |