Evaluation of a Dietary Supplement Containing Melissa Officinalis Formulated in Phospholipids on Mood Well-being and Cortisol Modulation

Pilot Study for the Evaluation of a Dietary Supplement Containing Melissa Officinalis Formulated in Phospholipids on Mood Well-being and Cortisol Modulation

This is a randomized, double-blind, placebo-controlled pilot study designed to evaluate the effect of an oral nutritional supplement containing Melissa officinalis formulated in phospholipids on mood and cortisol levels in healthy adults. Participants will be randomly assigned to receive either the active supplement or a placebo daily for 3 weeks. The primary outcome measures include changes in mood well-being, perceived stress, and salivary cortisol levels. The study aims to assess both efficacy and safety of the supplement in modulating stress response and emotional balance.

Inclusion Criteria:

• Age between 18 and 65 years
• Healthy volunteers as assessed by medical history and physical examination
• Willingness to comply with the study procedures

Exclusion Criteria:

• Current use of medications or supplements that may affect mood or cortisol levels
• Known allergy or sensitivity to Melissa officinalis or phospholipids
• History of psychiatric disorders (e.g., major depression, anxiety disorders)
• Significant comorbidities (e.g., cardiovascular, hepatic, renal diseases)
• Pregnant or breastfeeding women
• Participation in another clinical trial in the past 30 days