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The aim of this study is to investigate the postoperative pain relieving effect of preoperative genicular block in total knee arthroplasty surgery. The main questions it aims to answer are:
Researchers will compare postoperative pain in patients who received genicular block with those who did not.One group of patients will be administered 0.25% bupivacaine with the geniculate block method. The other group will not undergo any intervention. Both groups will be administered intravenous morphine for postoperative analgesia.
Patients scheduled for knee arthroplasty will be randomly assigned into two groups. One group will receive a genicular nerve block prior to surgery , while the other group will not undergo any interventional procedure. The genicular nerve block will be administered in three quadrants around the knee, with each injection consisting of 5 mL of 0.25% Marcaine. All injections will be performed by investigator MA. Patient assessments will be conducted by investigator MO. Postoperative intravenous analgesia will be provided to both groups.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Genicular block group | Active Comparator | this group consists of the patients receiving genicular block preoperatively and they will be given morfin with PCA (Patient controlled analgesia) and paracetamol 3x1000 mg intravenous and diclofenac 75 mg intramuscular (if needed) |
|
| patients only given PCA-morfin postoperatively | Active Comparator | this group consists of the patients given morfin with PCA, paracetamol 3x1000 mg and diclofenac (if needed) |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Genicular blocks (bupivakain) | Drug | Genicular block is a regional analgesic technique performed with USG |
|
| Measure | Description | Time Frame |
|---|---|---|
| Visual Analog Scale Measure | VAS scores are assessed at 0th, 24th and 48th hours post operatively VAS score consists of 0-10 in numbers, the bigger the number the worse the pain | 0-48 hours |
| opioid consumption | Morphine consumption is assesed by PCA | 0-48 hours |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Mustafa Azizoglu, Associated Professor | Contact | +90 5325667061 | dryalamaoglu@hotmail.com | |
| Mervenur Ozturk, Resident Doctor | Contact | +90 5525345189 | mervenurnurozturk@gmail.com |
| Name | Affiliation | Role |
|---|---|---|
| Mustafa Azizoglu, Associated Professor | Mersin university Faculty of Medicine, Department of Anesthesiology and Reanimation | Principal Investigator |
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| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 21609599 | Background | Wang T, Leng YF, Zhang Y, Kang YQ, Xue X, Zhang Y. [Preventive effects of ischemic postconditioning and penehyclidine hydrochloride on gastric against ischemia-reperfusion injury in rats]. Zhonghua Yi Xue Za Zhi. 2011 Apr 26;91(16):1130-5. Chinese. |
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Individual participant data (IPD) will not be shared due to ethical considerations and institutional policies on patient confidentiality.
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| ID | Term |
|---|---|
| D010149 | Pain, Postoperative |
| ID | Term |
|---|---|
| D011183 | Postoperative Complications |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D010146 | Pain |
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| ID | Term |
|---|---|
| D010323 | Passive Cutaneous Anaphylaxis |
| D000082 | Acetaminophen |
| D004008 | Diclofenac |
| ID | Term |
|---|---|
| D012882 | Skin Tests |
| D007159 | Immunologic Tests |
| D019411 | Clinical Laboratory Techniques |
| D019937 | Diagnostic Techniques and Procedures |
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| Patient Control Analgesia (PCA) Morphine group | Drug | this group consists of the patients no any intervention preoperatively and they will be given morfin with PCA (Patient controlled analgesia) and paracetamol 3x1000 mg intravenous and diclofenac 75 mg intramuscular (if needed) |
|
|
| Paracetamol (acetaminophen) + Diclofenac Sodium | Drug | All patients are given paracetamol (3x1000 mg) and diclofenac (if needed) |
|
| D009461 | Neurologic Manifestations |
| D012816 | Signs and Symptoms |
| D003933 | Diagnosis |
| D008919 | Investigative Techniques |
| D007158 | Immunologic Techniques |
| D000937 | Antigen-Antibody Reactions |
| D055633 | Immune System Phenomena |
| D000083 | Acetanilides |
| D000813 | Anilides |
| D000577 | Amides |
| D009930 | Organic Chemicals |
| D000814 | Aniline Compounds |
| D000588 | Amines |
| D010648 | Phenylacetates |
| D000146 | Acids, Carbocyclic |
| D002264 | Carboxylic Acids |