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Attention facilitates the allocation of processing resources and the control of behavior among competing stimuli. Current research focuses primarily on attention control networks in the dorsal frontoparietal (DAN) and ventral (VAN) cortex. However, typical laboratory experiments emphasize task-specific processing, neglecting the possible role of memory. Although a few studies have examined the contribution of memory to attention control, they have generally used simple tasks in the laboratory. These tasks are unlikely to produce true traces of episodic memory, which are - by definition - characterized by complex contextual information (what, where, when) and personal relevance. This research will therefore use an innovative protocol based on mobile phone technology to generate episodes in the participants' real lives and then measure the impact of these past personal experiences on attention allocation (by assessing eye movements) and on the activity of the DAN/VAN system (using functional imaging).
The main hypothesis of the study is that knowledge acquired during everyday life contributes to the subsequent allocation of processing resources, via engagement of the DAN/VAN attention systems.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Old vs new objects | Experimental | The following week after the "Old vs new objects" encoding phase of 3 weeks, participants will have an fMRI. During fMRI, participants will see objects already seen or not seen during the encoding phase. |
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| incongruent vs. congruent contexts | Experimental | The following week after the "incongruent vs. congruent contexts" encoding phase of 3 weeks, participants will have an fMRI. During fMRI, participants will see objects encoding in congruent or incongruent contexts. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Old vs new objects" encoding phase and fMRI | Behavioral | During the encoding phase, a set of 60 objects will be presented to the participants in their everyday life. Pictures of objects sent to their app mobile phone over a period of 3 weeks. The following week, participants will have an fMRI. During fMRI, participants will see objects already seen or not seen during the encoding phase. |
| Measure | Description | Time Frame |
|---|---|---|
| activation pattern in fMRI: "old vs. new" objects (intervention 1) | activation pattern in DAN/VAN system in fMRI experiments for the comparison of trials with gaze directed towards "seen/old vs. unseen/new" objects. | One time during the week after the 3 weeks encoding phase |
| Measure | Description | Time Frame |
|---|---|---|
| activation pattern in fMRI: "place" images in intervention 1 | activation pattern in DAN/VAN system in fMRI experiments when participants direct gaze towards the image depicting the location where they were at the time they received an object during the encoding phase, compared with trials when gaze is directed towards the image of a place that was not visited during the encoding phase. | One time during the week after the 3 weeks encoding phase |
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Inclusion Criteria:
Exclusion Criteria:
History of known neurological or psychiatric illness
Cognitive problems limiting the understanding of instructions
Recent taking psychotropic drugs (antidepressants, anxiolytics, antipsychotics). The main treatments not authorized during this research are the following: Psychotropic treatments (drugs that can induce changes in perception, sensation, mood, consciousness or behavior). Like what:
Antipsychotics (valproic acid, amisulpride, aripiprazole, clozapine, cyamemazin, haloperidol, loxapine, olanzapine, risperidone).
Antidepressants (Amitriptyline, Citalopram, Clomipramine, Duloxetine, Escitalopam, Fluoxetine, Mianserine, Mirtazapine, Nortriptyline, Paroxetine, Sertraline, Venlafaxine).
Anxyolitics
Pregnant or breastfeeding women
Persons deprived of their liberty by a judicial or administrative decision
Persons admitted to a health or social institution for purposes other than research
Adults subject to a legal protection measure (guardianship, curatorship)
Persons not affiliated to a social security scheme or beneficiaries of a similar scheme
Participation in another research study of the current study
Contraindication for fMRI scanning
Participant not agreeing to be informed in the event of the incidental discovery of an anomaly on MRI
• For visit number 2 :
Alcohol consumption (> 3 drinks) in the 24h before the experiment
Alcohol consumption the day of the experiment
Cafeine consumption 1 hour or less before the experiment
Drug consumption within the 24h preceding the experiment
Antimalarial treatment within the 3 days preceding the experiment
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Emiliano MACALUSO, Pr | Contact | 04 72 91 34 07 | +33 | emiliano.macaluso@univ-lyon1.fr |
| Samy Adrian FOUDIL | Contact | 07 77 36 37 68 | +33 | samy@samalgo.com |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| UCBL1, CRNL Inserm U1028, CNRS UMR5292, équipe IMPACT | Bron | Rhone | 69500 | France |
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Our main hypothesis concerning the role of personal past experiences in guiding spatial attention via the dorsal and ventral attention control system (DAN/VAN) will be tested in two fMRI studies in healthy participants. The use of mobile-mobile technology will allow us to control the formation of episodic memory traces in the real-world. In the testing phase, eye-tracking will permit us to assess the allocation of spatial attention, and fMRI will assess the activation of the attention systems as a function of condition (gaze/attention towards elements associated with previous personal experiences, i.e. pictures of old/seen objects or places, vs. pictures of new/unseen objects/places).
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| " incongruent vs. congruent contexts " encoding phase and fMRI | Behavioral | During the encoding phase, a set of 60 objects will be presented to the participants in their everyday life. Pictures of objects sent to their app mobile phone over a period of 3 weeks. This time, the objects will be chosen according to the participant's location. The following week, participants will have an fMRI. During fMRI, participants will see objects encoding in congruent/incongruent contexts. |
|
| activation pattern in fMRI: incongruent vs. congruent contexts (intervention 2) | activation pattern in DAN/VAN system in fMRI experiments for the comparison of trials with gaze directed towards old/seen objects encoded in incongruent vs congruent contexts. | One time during the week after the 3 weeks encoding phase |