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| Name | Class |
|---|---|
| Alcon, a Novartis Company | INDUSTRY |
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DSLT demonstrates a ≥ 20% reduction of IOP from pre-treatment baseline in POAG patients naïve of previous glaucoma treatment at 12 months.
DSLT enables newly diagnosed patients to remain well controlled and off medications
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Treatment naïve (including medication in either eye, previous laser or surgery) mild to moderate POA | (including medication in either eye, previous laser or surgery) mild to moderate POA |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| DSLT enables newly diagnosed patients to remain well controlled and off medications | Device | DSLT enables newly diagnosed patients to remain well controlled and off medications |
|
| Measure | Description | Time Frame |
|---|---|---|
| Success of IOP Reduction Through DSLT Utilization | Proportion of patients (%) with DSLT success as defined as IOP lowering of >20% and no additional medications or procedures at 12 months. | 12 months |
| Measure | Description | Time Frame |
|---|---|---|
| Other Improvements to Disease State through DSLT Treatment | • Change in mean deviation.. (dB) | 12 months |
| Other Improvements to Disease State through DSLT Treatment | • Change in RNFL /GCA (µm) |
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Inclusion Criteria:
Exclusion Criteria:
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55 Treatment naïve (including medication in either eye, previous laser or surgery) mild to moderate POAG subjects
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Derek J Arnson, Master of Education | Contact | 4804201005 | derek.arnson@researchavp.com | |
| Christine Funke, Medical Doctor | Contact | 4804201005 | christine.funke@BDPEC.com |
| Name | Affiliation | Role |
|---|---|---|
| Christine Funke, Medical Doctor | Barnet Dulaney Perkins Eye Centers | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Barnet Dulaney Perkins Eye Centers | Recruiting | Mesa | Arizona | 85206 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| Background | Radcliffe N. Direct Selective Laser Trabeculoplasty. Expanding Access to and Delivery of SLT Poses a Great Challenge. Glaucoma Today. 2022. | ||
| 37702635 | Background | Takusagawa HL, Hoguet A, Sit AJ, Rosdahl JA, Chopra V, Ou Y, Richter G, Kim SJ, WuDunn D. Selective Laser Trabeculoplasty for the Treatment of Glaucoma: A Report by the American Academy of Ophthalmology. Ophthalmology. 2024 Jan;131(1):37-47. doi: 10.1016/j.ophtha.2023.07.029. Epub 2023 Sep 14. | |
| 25429421 |
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Upon completion of the study collection, the investigators will share the findings of the DSLT treatment with other researchers to then be published
The data will be available after the study is completed tentatively 12/2026 and available for 12 months until 12/2027.
The investigators will allow other researchers to contact us for information and the study results, the final results is the only thing that others will have access to upon request.
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| ID | Term |
|---|---|
| D005902 | Glaucoma, Open-Angle |
| D005901 | Glaucoma |
| ID | Term |
|---|---|
| D009798 | Ocular Hypertension |
| D005128 | Eye Diseases |
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| 12 months |
| Other Improvements to Disease State through DSLT Treatment | • Overall IOP reduction (mmHG) | 12 months |
| Other Improvements to Disease State through DSLT Treatment | • Medication reduction (#0-5) | 12 months |
| Other Improvements to Disease State through DSLT Treatment | • SSIs (% on trabeculectomy, glaucoma drainage implant (GDI), other) | 12 months |
| Background |
| Narayanaswamy A, Leung CK, Istiantoro DV, Perera SA, Ho CL, Nongpiur ME, Baskaran M, Htoon HM, Wong TT, Goh D, Su DH, Belkin M, Aung T. Efficacy of selective laser trabeculoplasty in primary angle-closure glaucoma: a randomized clinical trial. JAMA Ophthalmol. 2015 Feb;133(2):206-12. doi: 10.1001/jamaophthalmol.2014.4893. |
| 30862377 | Background | Gazzard G, Konstantakopoulou E, Garway-Heath D, Garg A, Vickerstaff V, Hunter R, Ambler G, Bunce C, Wormald R, Nathwani N, Barton K, Rubin G, Buszewicz M; LiGHT Trial Study Group. Selective laser trabeculoplasty versus eye drops for first-line treatment of ocular hypertension and glaucoma (LiGHT): a multicentre randomised controlled trial. Lancet. 2019 Apr 13;393(10180):1505-1516. doi: 10.1016/S0140-6736(18)32213-X. Epub 2019 Mar 9. |
| 7789416 | Background | Latina MA, Park C. Selective targeting of trabecular meshwork cells: in vitro studies of pulsed and CW laser interactions. Exp Eye Res. 1995 Apr;60(4):359-71. doi: 10.1016/s0014-4835(05)80093-4. |