Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Class |
|---|---|
| University of Oslo | OTHER |
Not provided
Not provided
Not provided
The P-SONAR study is a large, observational, prospective cohort study. The overall aim of the study is to investigate whether plaque burden estimation by 2D ultrasound of the carotid and femoral arteries may enhance cardiovascular risk prediction beyond NORRISK-2
Design: The P-SONAR Study is a prospective cohort study of all men and women aged 45-74 years attending a health check at one of 10 ultrasound clinics in Norway.
Time schedule: Study inclusion and baseline examinations took place in the period April 2022- March 20025.
Current status: Ultrasound follow-up examinations take place from January 2025 - December 2029.
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Participants undergoing ultrasound and screening for conventional CV risk factors. | A sub-cohort consists of 5 500 participants who undergo both carotid and femoral ultrasound and fatty liver status assessment by ultrasound, in addition to assessement of traditional CV risk factors including history of smoking, total-cholesterol, LDL-cholesterol, HDL-cholesterol, Lp(a), blood glucose, systolic and diastolic blood pressure and waist circumference measurements. | ||
| Participants undergoing ultrasound examination | Total cohort consists of 22 000 participants who undergo both carotid and femoral ultrasound and fatty liver status assessment by ultrasound |
Not provided
| Measure | Description | Time Frame |
|---|---|---|
| Carotid and femoral plaque burden cardiovascular (CV) predictive ability beyond NORRISK-2 | Additative ability of carotid and femoral plaque burden assessed by ultrasound to predict incident cardiovascular events, beyond conventional risk factors by NORRISK-2 | From enrollment to an average of 10 years |
| May plaque burden predict incident cardiovascular disease. | Find best cutoff value of wTPT plaque burden to predict incident CV disease, across different age groups and sex. | From enrollment to an average of 10 years. |
Not provided
Not provided
Inclusion Criteria: Persons attending a health check during the study period.
-
Exclusion Criteria:
Not provided
Not provided
The study population comprises consecutive persons 45-74 years self-reffered for a health check in one of 10 ultrasound clinics in Norway.
Not provided
| Name | Affiliation | Role |
|---|---|---|
| Jonn-Terje Geitung, MD, PhD, MHA | University of Oslo | Principal Investigator |
| Serena N.H. Tonstad, MD, PhD | Oslo University Hospital | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Austad Diagnostikk | Oslo | East | 0366 | Norway |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 41952119 | Derived | Austad G, Geitung JT, Thomas O, Tonstad S. Discriminating established cardiovascular disease using a novel multiterritory ultrasound plaque burden measure (wTPT): findings from the P-SONAR study. BMC Cardiovasc Disord. 2026 Apr 9;26(1):428. doi: 10.1186/s12872-026-05807-8. |
Not provided
Not provided
Because of the sensitive nature of the data in this study, participants were assured that raw data would remain confidential and would not be shared.
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| ID | Term |
|---|---|
| D002318 | Cardiovascular Diseases |
| D005234 | Fatty Liver |
| D016893 | Carotid Stenosis |
| D020521 | Stroke |
| D050197 | Atherosclerosis |
| D000083242 | Ischemic Stroke |
| D017202 | Myocardial Ischemia |
| ID | Term |
|---|---|
| D008107 | Liver Diseases |
| D004066 | Digestive System Diseases |
| D002340 | Carotid Artery Diseases |
| D002561 | Cerebrovascular Disorders |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
| D001157 | Arterial Occlusive Diseases |
| D014652 | Vascular Diseases |
| D001161 | Arteriosclerosis |
| D006331 | Heart Diseases |
Not provided
Not provided