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There are nearly 300,000 patients with severe or intermediate thalassemia in China. Growth retardation is the most significant health issue for children and adolescents with transfusion-dependent thalassemia (TDT), placing a substantial economic burden on their families and a serious social strain on the labor force. Investigating the growth and development of these children and adolescents, and establishing targeted intervention plans, holds significant social value for public health practice.
To screen and identify pediatric patients with growth problems by conducting growth and development assessments in high-incidence areas of China, including physical development, endocrine function, nutritional status, brain function and lifestyle behaviors.
Implement the MENBS clinical interventions for pediatric patients with growth problems, concentrating on the following areas:
Repeat growth assessment for pediatric patients with growth problems after 1-year clinical interventions.
Evaluate the effectiveness of MENBS interventions by comparing changes in growth and development indicators.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Pediatric patients with growth problems | Experimental | We identify pediatric patients with growth problems by conducting growth and development assessments. Implement the MENBS clinical interventions for pediatric patients with growth problems. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| MENBS clinical interventions | Behavioral |
|
| Measure | Description | Time Frame |
|---|---|---|
| Height-for-age (m) | It is assessed using the 'Growth Standard for Children under 7 Years of Age' and the 'Standard for Height Level Classification among Children and Adolescents Aged 7-18 Years' issued by the National Health Commission | Up to 1 year |
| Body mass index-for-age (BMI-for-age, kg/m^2) | It is assessed using the 'Growth Standard for Children under 7 Years of Age' and the 'Dietary Guidelines for Chinese Residents'. | Up to 1 year |
| Puberty status | Puberty status will be measured using by Tanner scale (TS). It is a five-stage system to assess breast development (in girls), genital development (in boys), pubic hair growth (in both sexes). | Up to 1 year |
| Endocrine function | Endocrine function such as hormonal levels (IGF-1, GH, etc.) will be measured by clinical examination | Up to 1 year |
| Nutritional status | Nutritional status will be measured by clinical examination, such as concentration of Vitamin D and Zinc | Up to 1 year |
| Intelligence quotient (IQ) | IQ will be measured by scores obtained from Raven's Progressive Matrices. Raw scores are converted into percentile ranks or IQ scores based on age-group norms:
|
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Jingyu Zhao, MPH | Contact | 13752253515 | zhaojingyu@ihcams.ac.cn |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Regenerative Medicine Center and Red Blood Cell Disorders Center | Recruiting | Tianjin | Tianjin Municipality | China |
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|
| Up to 1 year |
| Brain function | Brain function will be measured by Functional Near-infrared Spectroscopy (fNIRS) to record brain activations | Up to 1 year |
| Quality of life | Quality of life will be measured using by Pediatric Quality of Life Inventory (PedsQL), with higher scores indicating better quality of life. The score range is 0-100. | Up to 1 year |
| ID | Term |
|---|---|
| D017086 | beta-Thalassemia |
| D011628 | Puberty, Delayed |
| D013789 | Thalassemia |
| ID | Term |
|---|---|
| D000745 | Anemia, Hemolytic, Congenital |
| D000743 | Anemia, Hemolytic |
| D000740 | Anemia |
| D006402 | Hematologic Diseases |
| D006425 | Hemic and Lymphatic Diseases |
| D006453 | Hemoglobinopathies |
| D030342 | Genetic Diseases, Inborn |
| D009358 | Congenital, Hereditary, and Neonatal Diseases and Abnormalities |
| D006058 | Gonadal Disorders |
| D004700 | Endocrine System Diseases |
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