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| Name | Class |
|---|---|
| China-Japan Friendship Hospital | OTHER |
| The Second Hospital of Hebei Medical University | OTHER |
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To investigate the efficacy and safety of the application of PRF combined PRP to the for the treatment of GPN.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| PRF group | Motor stimulation at 2 Hz, 1.0V will be performed and the negative results indicated that no muscle contraction will be generated. Afterwards, PRF treatment will be performed for 360 seconds. The parameters of PRF application were initiated at the voltage of 45 V, the temperature of 42°C, the pulse rate of 2Hz at the rate of 20 milliseconds. The pulse treatment generator will be set to the automatic pulsed radiofrequency mode, with a temperature of 42°C, pulse frequency of 2Hz, pulse width of 20ms and treatment duration of 360s. | ||
| PRF+PRP group | Motor stimulation at 2 Hz, 1.0V will be performed and the negative results indicated that no muscle contraction will be generated. Afterwards, PRF treatment will be performed for 360 seconds. The parameters of PRF application were initiated at the voltage of 45 V, the temperature of 42°C, the pulse rate of 2Hz at the rate of 20 milliseconds. The pulse treatment generator will be set to the automatic pulsed radiofrequency mode, with a temperature of 42°C, pulse frequency of 2Hz, pulse width of 20ms and treatment duration of 360s. PRF group will only receive PRF treatment, PRF combined with PRP group, after removing the radiofrequency electrode, 2 ml of LP-PRP mixture will be injected slowly. Additional analgesics will be administered for participants' comfort during and after the procedure. If the patients were not satisfied with the outcome after one month, other treatment options will be available. |
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| Measure | Description | Time Frame |
|---|---|---|
| Numeric rating scale (NRS) score | Numeric rating scale (NRS) score during resting was used to evaluate pain intensity before and after PRF treatment (0=no pain, 10=intolerable pain) | 1day, 3days, 1week, 2weeks, 1month, 3months, 6months, and 1year following the procedure |
| Measure | Description | Time Frame |
|---|---|---|
| Barrow Neurological Institute pain scale(BNI score) | BNI score during resting was used to evaluate pain relief | 1day, 3days, 1week, 2weeks, 1month, 3months, 6months, and 1year following the procedure |
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Inclusion Criteria:
Exclusion Criteria:
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Suitable participants will be screened at the pain management center of each hospital to participate in the study.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Fang Luo, M.D. | Contact | +86 13611326978 | 13611326978@163.com |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Beijing Tiantan Hospital | Recruiting | Beijing | Beijing Municipality | 100070 | China |
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| ID | Term |
|---|---|
| D020435 | Glossopharyngeal Nerve Diseases |
| ID | Term |
|---|---|
| D003389 | Cranial Nerve Diseases |
| D009422 | Nervous System Diseases |
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