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Elderly people are at a high risk for disturbances in water homeostasis, with both hypo- and hypernatremia being more common with increasing age. Several changes in the physiology of the ageing body are responsible for this predisposition towards hypo- and hypernatremia, including diminished thirst perception, decreasing kidney function, and altered body composition. In addition, age-related changes in AVP secretion have been suggested, but findings remain inconclusive. Possibly, this controversy is due to measurement challenges of AVP.
Copeptin, a surrogate marker of AVP-release, is more stable and a reliable assay is commercially available. While copeptin stimulation and suppression has been studied in healthy volunteers, no study assessed possible changes in copeptin dynamics occurring with ageing.
Therefore, the aim of this study is to investigate copeptin levels in hypo- and hyperosmolar states in generally healthy elderly adults compared to young controls. The investigators hypothesize that both the suppression and stimulation of copeptin is impaired and that the overall range of variation is diminished with increasing age.
This is a monocentric open-labeled randomized controlled trial conducted at the university hospital Basel. All participants will be scheduled for a copeptin stimulation test using hypertonic saline infusion and a copeptin suppression test using water ingestion. The order of the two study visits will be randomized at study inclusion.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Stimulation first, Suppression second | Experimental |
| |
| Suppression first, Stimulation second | Experimental |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Hypertonic 3% saline | Other | Participants receive 10 ml/kg body weight of 3% saline infused over 1 hour. The aim is to stimulate copeptin release. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Range of Variation in Copeptin | The primary outcome is the range of variation in copeptin, i.e. difference of suppressed copeptin to the stimulated copeptin, in healthy elderly participants compared to young controls. | Baseline, 15 minutes, 30 minutes, 45 minutes, 60 minutes, and 120 minutes both after saline administration and after water ingestion |
| Measure | Description | Time Frame |
|---|---|---|
| Changes in Copeptin upon stimulation and suppression | Baseline, 15 minutes, 30 minutes, 45 minutes, 60 minutes, and 120 minutes both after saline administration and after water ingestion | |
| Differences in total body water (L) measured by body impedance analysis |
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Inclusion Criteria:
Exclusion Criteria:
male female
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University Hospital Basel | Basel | Canton of Basel-City | 4031 | Switzerland |
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| ID | Term |
|---|---|
| D012965 | Sodium Chloride |
| D014867 | Water |
| ID | Term |
|---|---|
| D002712 | Chlorides |
| D006851 | Hydrochloric Acid |
| D017606 | Chlorine Compounds |
| D007287 | Inorganic Chemicals |
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| Water | Other | Participants ingest 20 ml/kg water over 1h. The aim is to suppress copeptin release. |
|
| at Baseline |
| Changes in cortisol (mmol/L) | Baseline, 60 minutes, and 120 minutes both after saline administration and after water ingestion |
| Number of participants with treatment-related adverse events as assessed by CTCAE v5.0 | Baseline, 15 minutes, 30 minutes, 45 minutes, 60 minutes, and 120 minutes both after saline administration and after water ingestion |
| Changes in blood pressure (mmHg) | Baseline, 15 minutes, 30 minutes, 45 minutes, 60 minutes, and 120 minutes both after saline administration and after water ingestion |
| Changes in heart rate | Baseline, 15 minutes, 30 minutes, 45 minutes, 60 minutes, and 120 minutes both after saline administration and after water ingestion |
| Changes in plasma sodium (mmol/L) | Baseline, 15 minutes, 30 minutes, 45 minutes, 60 minutes, and 120 minutes both after saline administration and after water ingestion |
| Changes in plasma potassium (mmol/L) | Baseline, 15 minutes, 30 minutes, 45 minutes, 60 minutes, and 120 minutes both after saline administration and after water ingestion |
| Changes in plasma chloride (mmol/L) | Baseline, 15 minutes, 30 minutes, 45 minutes, 60 minutes, and 120 minutes both after saline administration and after water ingestion |
| Changes in plasma osmolality (mOsm/kg) | Baseline, 15 minutes, 30 minutes, 45 minutes, 60 minutes, and 120 minutes both after saline administration and after water ingestion |
| Changes in estimated glomerular filtration rate (ml/kg/1.73m2) | Baseline, 60 minutes, and 120 minutes both after saline administration and after water ingestion |
| Changes in plasma glucose (mmol/L) | Baseline, 15 minutes, 30 minutes, 45 minutes, 60 minutes, and 120 minutes both after saline administration and after water ingestion |
| Changes in plasma urea (mmol/L) | Baseline, 15 minutes, 30 minutes, 45 minutes, 60 minutes, and 120 minutes both after saline administration and after water ingestion |
| Changes in plasma uric acid (umol/L) | Baseline, 15 minutes, 30 minutes, 45 minutes, 60 minutes, and 120 minutes both after saline administration and after water ingestion |
| Changes in urine osmolality (mOsm/kg) | Baseline, 60 minutes, and 120 minutes both after saline administration and after water ingestion |
| Changes in urine sodium (mmol/L) | Baseline, 60 minutes, and 120 minutes both after saline administration and after water ingestion |
| Changes in urine potassium (mmol/L) | Baseline, 60 minutes, and 120 minutes both after saline administration and after water ingestion |
| Changes in urine chloride (mmol/L) | Baseline, 60 minutes, and 120 minutes both after saline administration and after water ingestion |
| Changes in urine urea (mmol/L) | Baseline, 60 minutes, and 120 minutes both after saline administration and after water ingestion |
| Changes in urine uric acid (umol/L) | Baseline, 60 minutes, and 120 minutes both after saline administration and after water ingestion |
| Changes in urine glucose (mmol/L) | Baseline, 60 minutes, and 120 minutes both after saline administration and after water ingestion |
| Changes in urine creatinine (umol/L) | Baseline, 60 minutes, and 120 minutes both after saline administration and after water ingestion |
| D017670 |
| Sodium Compounds |
| D006878 | Hydroxides |
| D000468 | Alkalies |
| D000838 | Anions |
| D007477 | Ions |
| D004573 | Electrolytes |
| D010087 | Oxides |
| D017601 | Oxygen Compounds |