Prediction of Detoxification Effect of Fat Emulsion Based on Drug Diffusion Law

Prediction of Detoxification Effect of Fat Emulsion Based on Drug Diffusion Law: Clinical Observational Study

The goal of this observational study is to establish a predictive model for the clinical use value of fat emulsion as an antidote based on the physical information of fat emulsion on drug diffusion process.

The main question it aims to answer is:

Observing the effect of fat emulsion on the pharmacokinetic changes of overdose drugs; Observe and evaluate the therapeutic effect of long-chain fat emulsion as an antidote; Participants will have their whole blood samples collected for toxicology testing.

Inclusion Criteria:

• Patients with a clear history of acute drug exposure;
• The exposed drug is a lipid soluble drug (with a lipid water distribution coefficient logP>0);
• Age: 18-85 years old;
• The patient or guardian agrees to participate in this project and signs an informed consent form;

Exclusion Criteria:

• Patients with shock and severe lipid metabolism disorders (such as hyperlipidemia);
• Patients with unclear exposure history;
• Drug exposure time > 24 hours;
• Exposure to two or more drugs;
• Select patients with specific detoxifying agents;
• Merge patients with severe cardiovascular and cerebrovascular diseases;
• Patients with negative blood toxicity test results or overdose of non-fat-soluble drugs;
• Those who fail to provide complete general information and clinical data;