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Liver cirrhosis is a chronic liver disease characterized by significant scarring and dysfunction. One of its common complications is renal affection , which can significantly impact patient outcomes .
Aetiology of AKI can be categorized into three main types. These are prerenal (results from decreased renal perfusion), intrinsic renal (acute tubular necrosis), and postrenal AKI. In patients on admission, acute tubular necrosis is a common type of intrinsic AKI .
The development of portal hypertension in patients with liver cirrhosis leading to a reduction in systemic vascular resistance as a result of primary arterial vasodilation in the splanchnic circulation is the primary cause of AKI in cirrhotics. This mechanism primarily leads to hepatorenal syndrome. In addition, the underlying causes of liver cirrhosis can be the cause of intrinsic renal disease .
Early identification and management of AKI may improve outcomes. AKI in patients with liver cirrhosis in Egypt and their impact on inpatient mortality are largely unknown. This study was aimed at determining the prevalence, precipitating factors, predictors, and in-hospital mortality of AKI in patients with liver cirrhosis admitted at Al-Rajhi liver hospital at Egypt .
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| liver cirrhosis admitted to Al-Rajhi liver hospital | observation of renal affection in patients known to have liver cirrhosis |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| observation of renal affection in patients with liver cirrhosis | Other |
|
| Measure | Description | Time Frame |
|---|---|---|
| In-hospital mortality | Mortality during hospital stay | Through the study completion , average 6 months |
| Phenotypes of acute kidney injury across geographic areas | Characteristics of acute kidney injury (clinical type and stage) | Baseline ( at admission ), then through the study completion, average 6 months |
| Measure | Description | Time Frame |
|---|---|---|
| 28-day mortality | Mortality at 28 days | 28 days |
| Resolution of AKI | Resolution of AKI will be defined as return of serum creatinine to a value within 0.3 mg/di (26.5 mmol/L) of the baseline value. Partial response will be defined as regression of AKI to a lower stage with a reduction of serum creatinine to ≥0.3 mg/d| (26.5 mmol/L) above the baseline value |
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Inclusion Criteria:
Exclusion Criteria:
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Patients with liver cirrhosis admitted to the department .
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Mohamed Omar Abd El-Malek, professor | Contact | 0201007343214 | Omar7619@aun.edu.eg |
| Name | Affiliation | Role |
|---|---|---|
| Mohamed Omar Abd El-Malek, professor | Assiut University | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Al-Raghi liver hospital | Asyut | Assuit | Egypt |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 25032185 | Result | Choi YJ, Kim JH, Koo JK, Lee CI, Lee JY, Yang JH, Ko SY, Choe WH, Kwon SY, Lee CH. Prevalence of renal dysfunction in patients with cirrhosis according to ADQI-IAC working party proposal. Clin Mol Hepatol. 2014 Jun;20(2):185-91. doi: 10.3350/cmh.2014.20.2.185. Epub 2014 Jun 30. | |
| 31384350 | Result | Duah A, Nkrumah KN. Prevalence and predictors for spontaneous bacterial peritonitis in cirrhotic patients with ascites admitted at medical block in Korle-Bu Teaching Hospital, Ghana. Pan Afr Med J. 2019 May 16;33:35. doi: 10.11604/pamj.2019.33.35.18029. eCollection 2019. |
| Label | URL |
|---|---|
| https://scholar.google.com/scholar\_lookup?journal=Clinical%20and%20Molecular%20Hepatology\&title=Prevalence%20of%20renal%20dysfunction%20in%20patients%20with%20cirrhosis%20according%20to%20ADQI-IAC%20working%20party%20proposal\&author=Y.%20J.%20Choi\&author | View source |
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| ID | Term |
|---|---|
| D008103 | Liver Cirrhosis |
| ID | Term |
|---|---|
| D008107 | Liver Diseases |
| D004066 | Digestive System Diseases |
| D005355 | Fibrosis |
| D010335 | Pathologic Processes |
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| Hospital stay (up to 90 days) |
| Development of CKD | Chronic kidney disease will be defined as an estimated glomerular filtration rate <60 ml/min ml/min/1.73 m2 for >3 months. The Modification of Diet in Renal Disease equation will be used for estimating glomerular filtration rate | 90 days |
| D013568 |
| Pathological Conditions, Signs and Symptoms |