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Aromatase inhibitors (AI) therapy is the treatment of choice for estrogen receptor-positive breast cancer (BC). While AIs effectively suppress tumor growth, estrogen deprivation may have negative impacts on the eyes. This work evaluated the anterior segment changes in estrogen-dependent BC after hormonal treatment.
Aromatase inhibitors (AI) therapy is an important treatment for estrogen receptor-positive breast cancer (BC). This work evaluated the eye anterior segment changes in estrogen-dependent BC after hormonal treatment.
This cross-sectional study was conducted on female patients aged ≥18 who received treatment for BC. Patients were evaluated by a number of tests to determine the effects on the cornea and the lacrimal system
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| patients with breast cancer recieving hormonal treatment | Active Comparator | evaluation of the effect of hormonal treatment on the cornea |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Hormonal treatment | Drug | hormonal treatment for breast cancer |
|
| Measure | Description | Time Frame |
|---|---|---|
| tear break up time test and shirmer test | these tests done before starting treatment and in follow up after recieving treatment to evaluate the lacrimal function and dry eye | 6 months |
| Measure | Description | Time Frame |
|---|---|---|
| Corneal thickness and endothelium hexagonality | Corneal thickness and hesagonality were evaluated before and after treatment with aromatase inhibitors | 6 months |
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| Name | Affiliation | Role |
|---|---|---|
| Elshimaa abd almateen A mateen, Doctorate | Sohag University | Study Chair |
| alaa mahmoud m mahmoud | mahmoud | Study Chair |
| mohamed salah hamed s hamed, Doctorate | Sohag University | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Sohag university | Sohag | Egypt |
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| Label | URL |
|---|---|
| breast cancer therapy | View source |
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| ID | Term |
|---|---|
| D015352 | Dry Eye Syndromes |
| D001943 | Breast Neoplasms |
| ID | Term |
|---|---|
| D007766 | Lacrimal Apparatus Diseases |
| D005128 | Eye Diseases |
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
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| D001941 |
| Breast Diseases |
| D012871 | Skin Diseases |
| D017437 | Skin and Connective Tissue Diseases |